Pd-Catalyzed Highly Regio- and Stereoselective Formation of C–C Double Bonds: An Efficient Method for the Synthesis of Benzofuran‑, Dihydrobenzofuran‑, and Indoline-Containing Alkenes

Abstract

A highly regio- and stereoselective C–C double bond formation reaction via Pd-catalyzed Heck-type cascade process with <i>N</i>-tosylhydrazones has been developed. Various <i>N</i>-tosylhydrazones derived from both ketones and aldehydes are found to be efficient substrates to provide di- and trisubstituted olefins with high regio- and stereoselectivity. Furthermore, this reaction has a good functional group tolerance and different benzofuran-, dihydrobenzofuran-, and indoline-containing alkene products were obtained with high selectivity