Original Sin in Arminian Theology and its Antitheses

The study or this doctrine of original sin in Arminian theology and its antitheses shall be our theme, since it is beneficial for understanding the religious thinking of modern man

Order-disorder transition in nanoscopic semiconductor quantum rings

Using the path integral Monte Carlo technique we show that semiconductor quantum rings with up to six electrons exhibit a temperature, ring diameter, and particle number dependent transition between spin ordered and disordered Wigner crystals. Due to the small number of particles the transition extends over a broad temperature range and is clearly identifiable from the electron pair correlation functions.Comment: 4 pages, 5 figures, For recent information on physics of small systems see http://www.smallsystems.d

Optical Response of Grating-Coupler-Induced Intersubband Resonances: The Role of Wood's Anomalies

Grating-coupler-induced collective intersubband transitions in a quasi-two-dimensional electron system are investigated both experimentally and theoretically. Far-infrared transmission experiments are performed on samples containing a quasi-two-dimensional electron gas quantum-confined in a parabolic quantum well. For rectangular shaped grating couplers of different periods we observe a strong dependence of the transmission line shape and peak height on the period of the grating, i.e. on the wave vector transfer from the diffracted beams to the collective intersubband resonance. It is shown that the line shape transforms with increasing grating period from a Lorentzian into a strongly asymmetric line shape. Theoretically, we treat the problem by using the transfer-matrix method of local optics and apply the modal-expansion method to calculate the influence of the grating. The optically uniaxial quasi-two-dimensional electron gas is described in the long-wavelength limit of the random-phase approximation by a local dielectric tensor, which includes size quantization effects. Our theory reproduces excellently the experimental line shapes. The deformation of the transmission line shapes we explain by the occurrence of both types of Wood's anomalies.Comment: 28 pages, 7 figures. Physical Review B , in pres

Inelastic light scattering and the excited states of many-electron quantum dots

A consistent calculation of resonant inelastic (Raman) scattering amplitudes for relatively large quantum dots, which takes account of valence-band mixing, discrete character of the spectrum in intermediate and final states, and interference effects, is presented. Raman peaks in charge and spin channels are compared with multipole strengths and with the density of energy levels in final states. A qualitative comparison with the available experimental results is given.Comment: 5 pages, accepted in J. Phys.: Condens. Matte

Localized magnetoplasmon modes arising from broken translational symmetry in semiconductor superlattices

The electromagnetic propagator associated with the localized collective magnetoplasmon excitations in a semiconductor superlattice with broken translational symmetry, is calculated analytically within linear response theory. We discuss the properties of these collective excitations in both radiative and non-radiative regimes of the electromagnetic spectra. We find that low frequency retarded modes arise when the surface density of carriers at the symmetry breaking layer is lower than the density at the remaining layers. Otherwise a doublet of localized, high-frequency magnetoplasmon-like modes occurs.Comment: Revtex file + separate pdf figure

Extracellular vesicles swarm the cancer microenvironment: from tumor–stroma communication to drug intervention

Intercellular communication sets the pace for transformed cells to survive and to thrive. Extracellular vesicles (EVs), such as exosomes, microvesicles and large oncosomes, are involved in this process shuttling reciprocal signals and other molecules between transformed and stromal cells, including fibroblasts, endothelial and immune cells. As a result, these cells are adapted or recruited to a constantly evolving cancer microenvironment. Moreover, EVs take part in the response to anticancer therapeutics not least by promoting drug resistance throughout the targeted tumor. Finally, circulating EVs can also transport important molecules to remote destinations in order to prime metastatic niches in an otherwise healthy tissue. Although the understanding of EV biology remains a major challenge in the field, their characteristics create new opportunities for advances in cancer diagnostics and therapeutics

The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development

<p>Abstract</p> <p>Background</p> <p>Sphingosine-1-phosophate (S1P) is a biologically active sphingolipid metabolite that influences cellular events including differentiation, proliferation, and migration. S1P acts through five distinct cell surface receptors designated S1P_1-5R, with S1P₁R having the highest expression level in the developing heart. S1P₁R is critical for vascular maturation, with its loss leading to embryonic death by E14.5; however, its function during early cardiac development is not well known. Our previous studies demonstrated that altered S1P levels adversely affects atrioventricular (AV) canal development <it>in vitro</it>, with reduced levels leading to cell death and elevated levels inhibiting cell migration and endothelial to mesenchymal cell transformation (EMT).</p> <p>Results</p> <p>We determined, by real-time PCR analysis, that S1P₁R was expressed at least 10-fold higher than other S1P receptors in the developing heart. Immunohistochemical analysis revealed S1P₁R protein expression in both endothelial and myocardial cells in the developing atrium and ventricle. Using AV canal cultures, we observed that treatment with either FTY720 (an S1P_1,3,4,5R agonist) or KRP203 (an S1P₁R-specific agonist) caused similar effects on AV canal cultures as S1P treatment, including induction of cell rounding, inhibition of cell migration, and inhibition of EMT. <it>In vivo</it>, morphological analysis of embryonic hearts at E10.5 revealed that S1P₁R-/- hearts were malformed with reduced myocardial tissue. In addition to reduced myocardial tissue, E12.5 S1P₁R-/- hearts had disrupted morphology of the heart wall and trabeculae, with thickened and disorganized outer compact layer and reduced fibronectin (FN) deposition compared to S1P₁R+/+ littermates. The reduced myocardium was accompanied by a decrease in cell proliferation but not an increase in apoptosis.</p> <p>Conclusions</p> <p>These data indicate that S1P₁R is the primary mediator of S1P action in AV canal cultures and that loss of S1P₁R expression <it>in vivo </it>leads to malformed embryonic hearts, in part due to reduced fibronectin expression and reduced cell proliferation.</p

Polymeric Photoacids Based on Naphthols—Design Criteria, Photostability, and Light-Mediated Release

The implementation of photoswitches within polymers offers an exciting toolbox in the design of light-responsive materials as irradiation can be controlled both spatially and temporally. Herein, we introduce a range of water-soluble copolymers featuring naphthol-based chromophores as photoacids in the side chain. With that, the resulting materials experience a drastic increase in acidity upon stimulation with UV light and we systematically studied how structure and distance of the photoacid from the copolymer backbone determines polymerizability, photo-response, and photostability. Briefly, we used RAFT (reversible addition–fragmentation chain transfer) polymerization to prepare copolymers consisting of nona(ethylene glycol) methyl ether methacrylate (MEO9MA) as water-soluble comonomer in combination with six different 1-naphthol-based (“N”) monomers. Thereby, we distinguish between methacrylates (NMA, NOeMA), methacrylamides (NMAm, NOeMAm), vinyl naphthol (VN), and post-polymerization modification based on [(1-hydroxynaphthalen-2-amido)ethyl]amine (NOeMAm, NAmeMAm). These P(MEO9MAx-co-“N”y) copolymers typically feature a 4:1 MEO9MA to “N” ratio and molar masses in the range of 10 kg mol−1. After synthesis and characterization by using NMR spectroscopy and size exclusion chromatography (SEC), we investigated how potential photo-cleavage or photo-degradation during irradiation depends on the type and distance of the linker to the copolymeric backbone and whether reversible excited state proton transfer (ESPT) occurs under these conditions. In our opinion, such materials will be strong assets as light-mediated proton sources in nanostructured environments, for example, for the site-specific creation of proton gradients. We therefore exemplarily incorporated NMA into an amphiphilic block copolymer and could demonstrate the light-mediated release of Nile red from micelles formed in water as selective solvent. © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA