A Dynamic View of the Relationship between Software Development Outsourcing Propensity and Industry Environment

Despite the progress scholars have made on the relationship between IT outsourcing (ITO) and industry environment, our knowledge of this link is still ambiguous and limited. Drawing on recent research on the evolvement of ITO market, we extend our understanding by taking a dynamic view of this issue. Specifically, we focus on software development outsourcing (SDO) and three key elements of industry environment, namely resource munificence, industry concentration and technology change. We argue that the evolvement of ITO market has a moderating effect onthe relationship between SDO propensity and industry environment. Using industry-level data for U.S. private industries from 1998 to 2015, we find that industry environment’s impact on SDO propensity does change with the evolvement of the ITO market. Our findings provide insights on the relationship between SDO propensity and industry environment andindicate the importance of a dynamic view for understanding ITO-related phenomena

Parallel assembly of arbitrary defect-free atom arrays with a multi-tweezer algorithm

Defect-free atom arrays are an important precursor for quantum information processing and quantum simulation. Yet, large-scale defect-free atom arrays remain challenging to realize, due to the losses encountered when rearranging stochastically loaded atoms to achieve a desired target array. Here, we demonstrate a novel parallel rearrangement algorithm that uses multiple mobile tweezers to independently sort and compress atom arrays in a way that naturally avoids atom collisions. For a high degree of parallelism, the required number of moves scales as N^0.5 with respect to the target array size N, as opposed to existing single-tweezer algorithms that scale as N or larger. We further determine the optimal degree of parallelism to be a balance between the algorithmic speedup and intermodulation effects. The defect-free probability for a 225-atom array is demonstrated to be as high as 33(1)% in a room temperature setup after multiple cycles of rearrangement. The algorithm presented here can be implemented for any target array geometry with an underlying periodic structure

Ethyl 1-(6-chloro-3-pyridylmeth­yl)-5-methyl-1H-1,2,3-triazole-4-carboxyl­ate

In the title compound, C12H13ClN4O2, the triazole ring carries methyl and ethoxy­carbonyl groups, and is bound via a methyl­ene bridge to a chloro­pyridine unit. There is evidence for significant electron delocalization in the triazolyl system. Intra­molecular C—H⋯O and inter­molecular C—H⋯N hydrogen bonds stabilize the structure

Genomic Inference of the Metabolism and Evolution of the Archaeal Phylum Aigarchaeota

Microbes of the phylum Aigarchaeota are widely distributed in geothermal environments, but their physiological and ecological roles are poorly understood. Here we analyze six Aigarchaeota metagenomic bins from two circumneutral hot springs in Tengchong, China, to reveal that they are either strict or facultative anaerobes, and most are chemolithotrophs that can perform sulfide oxidation. Applying comparative genomics to the Thaumarchaeota and Aigarchaeota, we find that they both originated from thermal habitats, sharing 1154 genes with their common ancestor. Horizontal gene transfer played a crucial role in shaping genetic diversity of Aigarchaeota and led to functional partitioning and ecological divergence among sympatric microbes, as several key functional innovations were endowed by Bacteria, including dissimilatory sulfite reduction and possibly carbon monoxide oxidation. Our study expands our knowledge of the possible ecological roles of the Aigarchaeota and clarifies their evolutionary relationship to their sister lineage Thaumarchaeota

Investigating the Factual Knowledge Boundary of Large Language Models with Retrieval Augmentation

Knowledge-intensive tasks (e.g., open-domain question answering (QA)) require a substantial amount of factual knowledge and often rely on external information for assistance. Recently, large language models (LLMs) (e.g., ChatGPT), have demonstrated impressive prowess in solving a wide range of tasks with world knowledge, including knowledge-intensive tasks. However, it remains unclear how well LLMs are able to perceive their factual knowledge boundaries, particularly how they behave when incorporating retrieval augmentation. In this study, we present an initial analysis of the factual knowledge boundaries of LLMs and how retrieval augmentation affects LLMs on open-domain QA. Specially, we focus on three primary research questions and analyze them by examining QA performance, priori judgement and posteriori judgement of LLMs. We show evidence that LLMs possess unwavering confidence in their capabilities to respond to questions and the accuracy of their responses. Furthermore, retrieval augmentation proves to be an effective approach in enhancing LLMs' awareness of knowledge boundaries, thereby improving their judgemental abilities. Additionally, we also find that LLMs have a propensity to rely on the provided retrieval results when formulating answers, while the quality of these results significantly impacts their reliance. The code to reproduce this work is available at https://github.com/RUCAIBox/LLM-Knowledge-Boundary

The application of custom 3D-printed prostheses with ultra-short stems in the reconstruction of bone defects: a single center analysis

Objective: Considering the advantages and widespread presence of 3D-printing technology in surgical treatments, 3D-printed porous structure prostheses have been applied in a wide range of the treatments of bone tumor. In this research, we aimed to assess the application values of the 3D-printed custom prostheses with ultra-short stems for restoring bone defects and maintaining arthrosis in malignant bone tumors of lower extremities in children.Methods: Seven cases of pediatric patients were included in this study. In all cases, the prostheses were porous titanium alloy with ultra-short stems. MSTS 93 (Musculoskeletal Tumor Society) scores were recorded for the functional recovery of the limbs. VAS (Visual analogue scale) scores were utilized to assess the degree of painfulness for the patients. X-ray and MRI (magnetic resonance imaging) were applied to evaluate the bone integration, prostheses aseptic loosening, prostheses fracture, wound healing, and tumor recurrence during follow-up.Results: During follow-up, none of the patients developed any postoperative complications, including prostheses aseptic loosening, prostheses fracture, or tumor recurrence. Radiological examinations during the follow-up showed that prostheses implanted into the residual bone were stably fitted and bone defects were effectively reconstructed. The MSTS 93 scores were 24.9 ± 2.9 (20–28). VAS scores were decreased to 5.8 ± 1.2 (4.0–7.0). No statistically significant differences in leg length discrepancy were observed at the time of the last follow-up.Conclusion: 3D-printing technology can be effectively applied throughout the entire surgical treatment procedures of malignant bone tumors, offering stable foundations for the initial stability of 3D-printed prostheses with ultra-short stems through preoperative design, intraoperative precision operation, and personalized prosthesis matching. With meticulous postoperative follow-up, close monitoring of postoperative complications was ensured. These favorable outcomes indicate that the utilization of 3D-printed custom prostheses with ultra-short stems is a viable alternative for reconstructing bone defects. However, further investigation is warranted to determine the long-term effectiveness of the 3D-printing technique

Associations of personal care products use with reproductive outcomes of IVF/ICSI treatment

IntroductionPersonal care products (PCPs) contain a number of endocrine-disrupting chemicals (EDCs) that could potentially affect the reproductive function in women of childbearing age. However, studies focused on the effects of PCPs use on reproductive outcomes are very limited. The current study aimed to explore the relationships between PCPs use patterns and reproductive outcomes in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment.MethodsA total of 1500 women from the Tongji Reproductive and Environmental (TREE) study between December 2018 and January 2020 were included in this study. Participants provided characteristics of PCPs use within the previous three months. Retrieved oocyte number, mature oocyte number, two distinct pronuclei (2PN) zygote number, fertilization rate, cleavage rate, blastocyst formation rate, implantation, clinical pregnancy, miscarriage, and live birth were followed up as reproductive endpoints. Generalized linear regression model was utilized to assess the associations between various categories of PCPs use and reproductive endpoints of IVF/ICSI.ResultsAfter adjusting for relevant covariates, women who used skin care products ≥14 times per week had a reduction of 22.4% in the maturation rate (95% CI: -39.2%, -1.6%) compared to participants who did not use skin care products. After transferring fresh embryos, women who used cosmetics 1–2 times per week (adjusted OR = 2.2, 95% CI: 1.0, 4.8) or 3–7 times per week (adjusted OR = 2.5, 95% CI: 1.2, 5.2) had a higher possibility of miscarriage than those who did not use cosmetics. There was negative association between the use of gel or soap and the cleavage rate among women aged < 30 years old (P for interaction = 0.01). Among women with BMI ≥ 24 kg/m2, the use of gel or soap was negatively associated with the blastocyst formation rate (P for interaction = 0.04), while cosmetics use was negatively associated with the maturation rate (P for interaction = 0.001).ConclusionOur findings suggest that the use of PCPs in women of reproductive age have a potential adverse impact on IVF/ICSI outcomes, particularly skin care and cosmetic products

Interaction between Schwann cells and other cells during repair of peripheral nerve injury

Peripheral nerve injury (PNI) is common and, unlike damage to the central nervous system injured nerves can effectively regenerate depending on the location and severity of injury. Peripheral myelinating glia, Schwann cells (SCs), interact with various cells in and around the injury site and are important for debris elimination, repair, and nerve regeneration. Following PNI, Wallerian degeneration of the distal stump is rapidly initiated by degeneration of damaged axons followed by morphologic changes in SCs and the recruitment of circulating macrophages. Interaction with fibroblasts from the injured nerve microenvironment also plays a role in nerve repair. The replication and migration of injury-induced dedifferentiated SCs are also important in repairing the nerve. In particular, SC migration stimulates axonal regeneration and subsequent myelination of regenerated nerve fibers. This mobility increases SC interactions with other cells in the nerve and the exogenous environment, which influence SC behavior post-injury. Following PNI, SCs directly and indirectly interact with other SCs, fibroblasts, and macrophages. In addition, the inter- and intracellular mechanisms that underlie morphological and functional changes in SCs following PNI still require further research to explain known phenomena and less understood cell-specific roles in the repair of the injured peripheral nerve. This review provides a basic assessment of SC function post-PNI, as well as a more comprehensive evaluation of the literature concerning the SC interactions with macrophages and fibroblasts that can influence SC behavior and, ultimately, repair of the injured nerve