Electronic Structure and Energy Band of IIIA Doped Group ZnO Nanosheets

The electronic and magnetic properties of IIIA group doped ZnO nanosheets (ZnONSs) are investigated by the first principles. The results show that the band gap of ZnO nanosheets increases gradually along with Al, Ga, and In ions occupying Zn sites and O sites. The configuration of Al atoms replacing Zn atoms is more stable than other doped. The system shows half-metallic characteristics for In-doped ZnO nanosheets

Lessons Learned from Applications of IoT at Social Spheres

Although Taiwan made its well-respected economic achievements at the catch-up period, the country is in transition to innovation-driven economic upgrading, which is recently being promoted by a strategic policy package of so-called the Industrial Transformation Program, focusing on 5+N innovative industries. Unlike the previous focus on modularized intermediate goods in the industrialization stage, the new policy package calls for innovation with strong flavor of cross-fertilization, solution-orientation, software and hardware integration. A key issue of this paper is how a latecomer like Taiwan may innovate in a post catch-up manner, which requires a latecomer country to establish new technological trajectories for innovation in a changing competitive environment where scarce opportunity for imitation is present. The paper sets out to examine the ways in which how Taiwanese firms approach or harness IoT innovations, especially via applications at the social sphere. It seems to present more challenges than IoT applications inside the firm (for example Industry 4.0) for the reason that IoT applications at social sphere are related to the aspects of behavior and social interfaces of the broadly-defined customer space.As a result, for innovators in Taiwan, they need to address the social interface involved in an appropriate manner. In many cases, they also need compound innovations, especially in conjunction with business models, not just technological innovation alone. Therefore, innovators in Taiwan have to change the way in which they innovate and interact with the changing innovation ecosystems. Especially in the emerging innovative sectors as 5+N innovative industries targeted by the government, the evolving innovation ecosystems are intrinsically international. Based on two intensive case studies, we would like to draw some lessons learned in Taiwan, which may enrich our understanding of factors underlying industrial innovations in the era of the digital economy, especially for latecomer countries in transition

Post Catch-up with Market Cultivation and Product Servicizing: Case of Taiwan\u27s Transportation Equipment Industries

This paper sets out to examine a key issue: how a latecomer, like Taiwan may develop its industry in a post catch-up manner. We make intensive inquiries into this issue via case studies on two sectors in Taiwan, namely the bicycle industry and the electric vehicle industry. One challenge to post catch-up is related to the situation where innovation model and path are at the fluid phase and where scarce opportunity for imitation is present. This has led us to giving special account to fuzzy front-end at the industrial level and how market cultivation and innovative business models come to play an important role in shaping the innovation path for post catch-up. For a couple of leading players in Taiwan’s bicycle industry, a key issue they faced was how to transform themselves and local setting in Taiwan to become a leader in high-end bicycles, in an attempt to fend off escalated international competition. In the emerging EV industry, the Taiwanese players try to overcome its structural weaknesses in the mainstream automotive industry to explore the possibility of levelling the playing field with the forerunners in the advanced countries. Our case studies suggest that technological catch-up is not necessarily a prelude to post catch-up, depending on the nature of new innovation trajectory and entry modes of the emerging industry. While the way in which a latecomer’s industry to rise in a post-catch-up manner has something to do with path dependence, something can be done to overcome the path dependence. Our analyses also lend support to the importance of product servicizing as a means of post catch-up, especially from the perspective of market cultivation. On balance, for post catch-up at an industrial level, a latecomer’s innovation system and its boundaries have to be shaped in line with the country’s level of technological accumulation, constituent firm’s strategy, the complexity of the innovation at issue, and the way in which the focal industry is emerging

Drosophila eyes absent is a Novel mRNA Target of the Tristetraprolin (TTP) Protein DTIS11

The Tristetraprolin (TTP) protein family includes four mammalian members (TTP, TIS11b, TIS11d, and ZFP36L3), but only one in Drosophila melanogaster (DTIS11). These proteins bind target mRNAs with AU-rich elements (AREs) via two C3H zinc finger domains and destabilize the mRNAs. We found that overexpression of mouse TIS11b or DTIS11 in the Drosophila retina dramatically reduced eye size, similar to the phenotype of eyes absent (eya) mutants. The eya transcript is one of many ARE-containing mRNAs in Drosophila. We showed that TIS11b reduced levels of eya mRNA in vivo. In addition, overexpression of Eya rescued the TIS11b overexpression phenotype. RNA pull-down and luciferase reporter analyses demonstrated that the DTIS11 RNA-binding domain is required for DTIS11 to bind the eya 3′ UTR and reduce levels of eya mRNA. Moreover, ectopic expression of DTIS11 in Drosophila S2 cells decreased levels of eya mRNA and reduced cell viability. Consistent with these results, TTP proteins overexpressed in MCF7 human breast cancer cells were associated with eya homologue 2 (EYA2) mRNA, and caused a decrease in EYA2 mRNA stability and cell viability. Our results suggest that eya mRNA is a target of TTP proteins, and that downregulation of EYA by TTP may lead to reduced cell viability in Drosophila and human cells