Bis(dimethyl­ammonium) 2,2′-(1,3,6,8-tetra­oxo-2,7-diaza­pyrene-2,7-di­yl)diacetate

The asymmetric unit of title compound, 2C2H8N+·C18H8N2O8 2−, comprises one crystallographically independent dimethyl­ammonium cation and half of a 2,2′-(1,3,6,8-tetra­oxo-2,7-diaza­pyrene-2,7-di­yl)diacetate dianion. The anion lies on an inversion centre and the two carboxyl­ate groups are in trans positions based on the naphthaleneteracarb­oxy­lic diimide group. The crystal packing is stabilized by N—H⋯O hydrogen bonds between cations and anions, as well as by π–π inter­actions between the naph­thaleneteracarb­oxy­lic diimide groups [centroid–centroid distance = 4.812 (3) Å]

Crystal structure of ethanol-bis(N-((5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrol-2-yl)methylene)benzohydrazonato-κ2N,O)copper(II), C36H42N6O7Cu

Abstract C20H29N3O5, triclinic, P1̄ (no. 2), a = 8.482(6) Å, b = 15.272(12) Å, c = 15.285(12) Å, a = 112.024(11)°, β = 95.325(9)°, γ = 98.958(9)°, V = 1788(2) Å3, Z = 2, R gt(F) = 0.0570, wR ref(F 2) = 0.1687, T = 296(2) K

(E)-(2,4-Dichloro­phen­yl)[2-hydr­oxy-6-(methoxy­imino)cyclo­hex-1-en­yl]methanone

The title compound, C14H13Cl2NO3, was obtained as the product of an attempted synthesis of herbicidally active compounds containing oxime ether and cyclo­hexenone groups. In the crystal structure, the mol­ecule adopts an endocyclic enol tautomeric form and the cyclo­hexene ring adopts a distorted envelope form. The oxime ether group has an E configuration, with the meth­oxy group anti to the ortho-chloro substitutent. Intra­molecular O—H⋯O and inter­molecular C—H⋯O hydrogen bonds are found in the crystal structure

Bis(benzoyl­acetonato)bis­(1,3-di-4-pyridyl­propane)manganese(II)

In the title compound, [Mn(C10H9O2)2(C13H14N2)2], the MnII ion lies on a crystallographic inversion center and has a slightly distorted octa­hedral coordination environment. Weak π–π stacking inter­actions, with centroid–centroid distances of 3.862 (2) and 3.887 (5) Å, and significant C—H⋯π inter­actions help to stabilize the crystal structure. The atoms of the unique terminal 4-pyridine­propane group are disordered over two sites, the ratio of refined occpancies being 0.712 (7):0.288 (7)

A Multimode Responsive Aptasensor for Adenosine Detection

We report a novel multimode detection aptasensor with three signal responses (i.e., fluorescence recovery, enhanced Raman signal, and color change). The presence of adenosine induces the conformational switch of the adenosine aptamer (Apt), forming adenosine-aptamer complex and releasing quantum dots (QDs) from AuNPs, resulting in the recovered fluorescence, the enhanced Raman signal, and color change of the solution. The multimode signal recognition is potentially advantageous in improving the precision and reliability of the detection in complex environments compared to the conventional single-mode sensing system. The multimode detection strategy opens up a new possibility in sensing and quantifying more other target molecules

Salt stress-induced FERROCHELATASE 1 improves resistance to salt stress by limiting sodium accumulation in Arabidopsis thaliana

Ferrochelatase-1 as a terminal enzyme of heme biosynthesis regulates many essential metabolic and physiological processes. Whether FC1 is involved in plant response to salt stress has not been described. This study shows that Arabidopsis overexpressing AtFC1 displays resistance to high salinity, whereas a T-DNA insertion knock-down mutant fc1 was more sensitive to salt stress than wild-type plants. AtFC1 conferred plant salt resistance by reducing Na+ concentration, enhancing K+ accumulation and preventing lysis of the cell membrane. Such observations were associated with the upregulation of SOS1, which encodes a plasma membrane Na+/H+ antiporter. AtFC1 overexpression led to a reduced expression of several well known salt stress-responsive genes such as NHX1 and AVP1, suggesting that AtFC1-regulated low concentration of Na+ in plants might not be through the mechanism for Na+ sequestration. To investigate the mechanism leading to the role of AtFC1 in mediating salt stress response in plants, a transcriptome of fc1 mutant plants under salt stress was profiled. Our data show that mutation of AtFC1 led to 490 specific genes up-regulated and 380 specific genes down-regulated in fc1 mutants under salt stress. Some of the genes are involved in salt-induced oxidative stress response, monovalent cation-proton (Na+/H+) exchange, and Na+ detoxification

Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice

<p>Abstract</p> <p>Objective</p> <p>Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, has been reported to have potential antioxidant properties. However, the role of HO-1 on hepatocyte apoptosis remains unclear. We aim to elucidate the effects of HO-1 on oxidative stress related hepatocellular apoptosis in nutritional steatohepatitis in mice.</p> <p>Methods</p> <p>C57BL/6J mice were fed with methionine-choline deficient (MCD) diet for four weeks to induce hepatic steatohepatitis. HO-1 chemical inducer (hemin), HO-1 chemical inhibitor zinc protoporphyrin IX (ZnPP-IX) and/or adenovirus carrying HO-1 gene (Ad-HO-1) were administered to mice, respectively. Hepatocyte apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, the mRNA and protein expression of apoptosis related genes were assayed by quantitative real-time PCR and Western blot.</p> <p>Results</p> <p>Hepatocyte signs of oxidative related apoptotic injury were presented in mice fed with MCD diet for 4 weeks. Induction of HO-1 by hemin or Ad-HO-1 significantly attenuated the severity of liver histology, which was associated with decreased hepatic lipid peroxidation content, reduced number of apoptotic cells by TUNEL staining, down-regulated expression of pro-apoptosis related genes including Fas/FasL, Bax, caspase-3 and caspase-9, reduced expression of cytochrome p4502E1 (CYP2E1), inhibited cytochrome c (Cyt-c) release, and up-regulated expression of anti-apoptosis gene Bcl-2. Whereas, inhibition of HO-1 by ZnPP-IX caused oxidative stress related hepatic injury, which concomitant with increased number of TUNEL positive cells and up-regulated expression of pro-apoptosis related genes.</p> <p>Conclusions</p> <p>The present study provided evidences for the protective role of HO-1 in preventing nutritional steatohepatitis through suppressing hepatocyte apoptosis in mice.</p

A Search for Radio Pulsars in Supernova Remnants Using FAST with One Pulsar Discovered

We report on the results of a search for radio pulsars in five supernova remnants (SNRs) with FAST. The observations were made using the 19-beam receiver in the Snapshot mode. The integration time for each pointing is 10 min. We discovered a new pulsar PSR J1845$-$0306 which has a spin period of 983.6 ms and a dispersion measure of 444.6$\pm$2.0 cm$^{-3}$ pc in observations of SNR G29.6+0.1. To judge the association between the pulsar and the SNR, further verification is needed. We also re-detected some known pulsars in the data from SNRs G29.6+0.1 and G29.7$-$0.3. No pulsars were detected in observations of other three SNRs.Comment: 6 pages, 2 figures, 2 tables published in CP