GPER-induced signaling is essential for the survival of breast cancer stem cells.

G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non-BCSCs of three patient-derived xenografts of ER- /PR+ breast cancers. GPER silencing reduced stemness features of BCSCs as reflected by reduced mammosphere forming capacity in vitro, and tumor growth in vivo with decreased BCSC populations. Comparative phosphoproteomics revealed greater GPER-mediated PKA/BAD signaling in BCSCs. Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD-Ser118 to sustain BCSC characteristics. Transfection with a dominant-negative mutant BAD (Ser118Ala) led to reduced cell survival. Taken together, GPER and its downstream signaling play a key role in maintaining the stemness of BCSCs, suggesting that GPER is a potential therapeutic target for eradicating BCSCs

Scaling of Anisotropic Flows and Nuclear Equation of State in Intermediate Energy Heavy Ion Collisions

Elliptic flow ($v_2$) and hexadecupole flow ($v_4$) of light clusters have been studied in details for 25 MeV/nucleon $^{86}$Kr + $^{124}$Sn at large impact parameters by Quantum Molecular Dynamics model with different potential parameters. Four parameter sets which include soft or hard equation of state (EOS) with/without symmetry energy term are used. Both number-of-nucleon ($A$) scaling of the elliptic flow versus transverse momentum ($p_t$) and the scaling of $v_4/A^{2}$ versus $(p_t/A)^2$ have been demonstrated for the light clusters in all above calculation conditions. It was also found that the ratio of $v_4/{v_2}^2$ keeps a constant of 1/2 which is independent of $p_t$ for all the light fragments. By comparisons among different combinations of EOS and symmetry potential term, the results show that the above scaling behaviors are solid which do not depend the details of potential, while the strength of flows is sensitive to EOS and symmetry potential term.Comment: 5 pages, 5 figure

A new 111 type iron pnictide superconductor LiFeP

A new iron pnictide LiFeP superconductor was found. The compound crystallizes into a Cu2Sb structure containing an FeP layer showing superconductivity with maximum Tc of 6K. This is the first 111 type iron pnictide superconductor containing no arsenic. The new superconductor is featured with itinerant behavior at normal state that could helpful to understand the novel superconducting mechanism of iron pnictide compounds.Comment: 3 figures + 1 tabl

Schwinger model on a half-line

We study the Schwinger model on a half-line in this paper. In particular, we investigate the behavior of the chiral condensate near the edge of the line. The effect of the chosen boundary condition is emphasized. The extension to the finite temperature case is straightforward in our approach.Comment: 4 pages, no figure. Final version to be published on Phys. Rev.

Study on Suburban Land Use Optimization from the Perspective of Flood Mitigation—A Case Study of Pujiang Country Park in Shanghai

\ua9 2024 by the authors. The integration of nature-based solutions into land use optimization has become a central focus of current research, primarily due to its effectiveness in mitigating flooding impacts and promoting sustainable development in both urban and rural areas. Taking Shanghai’s Pujiang Country Park as a case study, this paper conducts a simulation analysis to assess the flood mitigation effectiveness of three distinct land use patterns (Natural scenario, Scenario N; Complete urbanization scenario, Scenario U; Country Park Planning scenario, Scenario P) under five stormwater scenarios with return periods of 2, 5, 10, 20, and 50 years. The findings reveal that Scenario P exhibits superior flood mitigation performance, particularly under stormwater scenarios with a return period of less than 50 years. Building upon these results, the paper proposes recommendations for optimizing land use to mitigate the impact of flooding. This study is crucial for understanding the mechanisms involved in urban stormwater logging mitigation through land use methods and holds significance for decision-making in land use and planning at the micro level

From Composite Fermions to Calogero-Sutherland Model: Edge of Fractional Quantum Hall Liquid and the Dimension Reduction

We derive a microscopic model describing the low-lying edge excitations in the fractional quantum Hall liquid with $\nu=\frac{\nu^*} {\tilde\phi\nu^*+1}$. For $\nu^*>0$, it is found that the composite fermion model reduces to an SU$(\nu^*)$ Calogero-Sutherland model in a dimension reduction, whereas it is not exact soluble for $\nu^*<0$. However, the ground states in both cases can be found and the low-lying excitations can be shown the chiral Luttinger liquid behaviors. On the other hand, we shows that the finite temperature behavior of $G-T$ curve will deviate from the prediction of the chiral Luttinger liquid. We also point out that the suppression of the `spin' degrees of freedom agrees with very recent experiments by Chang et al. The two-boson model of Lee and Wen is described microscopically.Comment: 4 pages, Revtex, accepted for publication by PR

Magnetic impurities in the one-dimensional spin-orbital model

Using one-dimensional spin-orbital model as a typical example of quantum spin systems with richer symmetries, we study the effect of an isolated impurity on its low energy dynamics in the gapless phase through bosonization and renormalization group methods. In the case of internal impurities, depending on the symmetry, the boundary fixed points can be either an open chain with a residual spin or (and) orbital triplet left behind, or a periodic chain. However, these two fixed points are indistinguishable in the sense that in both cases, the lead-correction-to-scaling boundary operators (LCBO) only show Fermi-liquid like corrections to thermodynamical quantities. (Except the possible Curie-like contributions from the residual moments in the latter cases.) In the case of external (Kondo) impurities, the boundary fixed points, depending on the sign of orbital couplings, can be either an open chain with an isolated orbital doublet due to Kondo screening or it will flow to an intermediate fixed point with the same LCBO as that of the two-channel Kondo problem. Comparison with the Kondo effect in one-dimensional (1D) Heisenberg spin chain and multi-band Hubbard models is also made.Comment: 7 pages, No figur