The thermal analysis of cutting/grinding processes by meshless finite block method

© 2018 Elsevier Ltd Development of the Finite Block Method (FBM) is presented, with the introduction of infinite elements for the first time, for predicting stationary and transient heat conduction in cutting/grinding processes. Utilizing the Lagrange series the first order partial differential matrix is derived, adopting a mapping technique, followed by the construction of the higher order derivative matrix. For linear stationary heat conductivity three free parameters including the velocity of the workpiece, the cooling coefficient and the inclined angle of the contact zone, together with their effects on temperature, are observed. For the transient heat conduction study, the Laplace transformation method and Durbin's inverse technique are employed. Numerical solutions are discussed and comparisons made with the finite element method and analytical solutions, demonstrating the accuracy and convergence of the finite block method

Improved three-dimensional color-gradient lattice Boltzmann model for immiscible two-phase flows

In this paper, an improved three-dimensional color-gradient lattice Boltzmann (LB) model is proposed for simulating immiscible two-phase flows. Compared with the previous three-dimensional color-gradient LB models, which suffer from the lack of Galilean invariance and considerable numerical errors in many cases owing to the error terms in the recovered macroscopic equations, the present model eliminates the error terms and therefore improves the numerical accuracy and enhances the Galilean invariance. To validate the proposed model, numerical simulations are performed. First, the test of a moving droplet in a uniform flow field is employed to verify the Galilean invariance of the improved model. Subsequently, numerical simulations are carried out for the layered two-phase flow and three-dimensional Rayleigh-Taylor instability. It is shown that, using the improved model, the numerical accuracy can be significantly improved in comparison with the color-gradient LB model without the improvements. Finally, the capability of the improved color-gradient LB model for simulating dynamic two-phase flows at a relatively large density ratio is demonstrated via the simulation of droplet impact on a solid surface

Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients

<br>Background:Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current study is to establish if AR phosphorylation by Cdk1 or ERK1/2 is of prognostic significance.</br> <br>Methods: Scansite 2.0 was utilised to predict which AR sites are phosphorylated by Cdk1 and ERK1/2. Immunohistochemistry for these sites was then performed on 90 hormone-naive prostate cancer specimens. The interaction between Cdk1/ERK1/2 and AR phosphorylation was investigated in vitro using LNCaP cells.</br><br>Results:Phosphorylation of AR at serine 515 (pAR(S515)) and PSA at diagnosis were independently associated with decreased time to biochemical relapse. Cdk1 and pCdk1(161), but not ERK1/2, correlated with pAR(S515). High expression of pAR(S515) in patients with a PSA at diagnosis of ≤20 ng ml(-1) was associated with shorter time to biochemical relapse (P=0.019). This translated into a reduction in disease-specific survival (10-year survival, 38.1% vs 100%, P<0.001). In vitro studies demonstrated that treatment with Roscovitine (a Cdk inhibitor) caused a reduction in pCdk1(161) expression, pAR(S515)expression and cellular proliferation.</br> <br>Conclusion: In prostate cancer patients with PSA at diagnosis of ≤20 ng ml(-1), phosphorylation of AR at serine 515 by Cdk1 may be an independent prognostic marker.</br&gt

First Precambrian palaeomagnetic data from the Mawson Craton (East Antarctica) and tectonic implications

A pilot palaeomagnetic study was conducted on the recently dated with in situ SHRIMP U-Pb method at 1134 ± 9 Ma (U-Pb, zircon and baddeleyite) Bunger Hills dykes of the Mawson Craton (East Antarctica). Of the six dykes sampled, three revealed meaningful results providing the first well-dated Mesoproterozoic palaeopole at 40.5°S, 150.1°E (A95 = 20°) for the Mawson Craton. Discordance between this new pole and two roughly coeval poles from Dronning Maud Land and Coats Land (East Antarctica) demonstrates that these two terranes were not rigidly connected to the Mawson Craton ca. 1134 Ma. Comparison between the new pole and that of the broadly coeval Lakeview dolerite from the North Australian Craton supports the putative ~40° late Neoproterozoic relative rotation between the North Australian Craton and the combined South and West Australian cratons. A mean ca. 1134 Ma pole for the Proto-Australia Craton is calculated by combining our new pole and that of the Lakeview dolerite after restoring the 40° intracontinental rotation. A comparison of this mean pole with the roughly coeval Abitibi dykes pole from Laurentia confirms that the SWEAT reconstruction of Australia and Laurentia was not viable for ca. 1134 Ma

Arsenic Trioxide Enhances the Radiation Sensitivity of Androgen-Dependent and -Independent Human Prostate Cancer Cells

Prostate cancer is the most common malignancy in men. In the present study, LNCaP (androgen-sensitive human prostate cancer cells) and PC-3 cells (androgen-independent human prostate cancer cells) were used to investigate the anti-cancer effects of ionizing radiation (IR) combined with arsenic trioxide (ATO) and to determine the underlying mechanisms in vitro and in vivo. We found that IR combined with ATO increases the therapeutic efficacy compared to individual treatments in LNCaP and PC-3 human prostate cancer cells. In addition, combined treatment showed enhanced reactive oxygen species (ROS) generation compared to treatment with ATO or IR alone in PC-3 cells. Combined treatment induced autophagy and apoptosis in LNCaP cells, and mainly induced autophagy in PC-3 cells. The cell death that was induced by the combined treatment was primarily the result of inhibition of the Akt/mTOR signaling pathways. Furthermore, we found that the combined treatment of cells pre-treated with 3-MA resulted in a significant change in AO-positive cells and cytotoxicity. In an in vivo study, the combination treatment had anti-tumor growth effects. These novel findings suggest that combined treatment is a potential therapeutic strategy not only for androgen-dependent prostate cancer but also for androgen-independent prostate cancer