Political preferences and threat perception: opportunities for neuroimaging and developmental research

People have preferences for how their social environment is organized and governed. One influential explanation of variation in these preferences focuses on individual differences in sensitivity to threats. Recent research demonstrates that this relationship is a function not only of the degree of sensitivity (greater or lesser), but also of the danger in question (i.e. immigration or climate change) and the kind of potential harm it poses (i.e. physical pain or contamination). Since many political issues are not unambiguously of one kind, the structure of an individual's reactions to perceived political threats is also uncertain. We argue that future research should (i) use functional neuroimaging to test these structures and (ii) investigate the role of social learning in their transmission

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Rigidity analysis of HIV-1 protease

We present a rigidity analysis on a large number of X-ray crystal structures of the enzyme HIV-1 protease using the 'pebble game' algorithm of the software FIRST. We find that although the rigidity profile remains similar across a comprehensive set of high resolution structures, the profile changes significantly in the presence of an inhibitor. Our study shows that the action of the inhibitors is to restrict the flexibility of the beta-hairpin flaps which allow access to the active site. The results are discussed in the context of full molecular dynamics simulations as well as data from NMR experiments.Comment: 4 pages, 3 figures. Conference proceedings for CMMP conference 2010 which was held at the University of Warwic