Enhancing financial stability: the case of financial market utilities

The sweeping overhaul of the nation’s financial regulatory system that was signed into law on July 21, 2010, will touch virtually every aspect of financial markets. This Chicago Fed Letter focuses on provisions in the Dodd–Frank Wall Street Reform and Consumer Protection Act that affect “financial market utilities,” critical behind-the-scenes institutions and arrangements that ensure the smooth functioning of financial markets.Financial crises ; Financial markets

Control of stochastic and induced switching in biophysical networks

Noise caused by fluctuations at the molecular level is a fundamental part of intracellular processes. While the response of biological systems to noise has been studied extensively, there has been limited understanding of how to exploit it to induce a desired cell state. Here we present a scalable, quantitative method based on the Freidlin-Wentzell action to predict and control noise-induced switching between different states in genetic networks that, conveniently, can also control transitions between stable states in the absence of noise. We apply this methodology to models of cell differentiation and show how predicted manipulations of tunable factors can induce lineage changes, and further utilize it to identify new candidate strategies for cancer therapy in a cell death pathway model. This framework offers a systems approach to identifying the key factors for rationally manipulating biophysical dynamics, and should also find use in controlling other classes of noisy complex networks.Comment: A ready-to-use code package implementing the method described here is available from the authors upon reques

Resource management implications of ERTS-1 data to Ohio

Initial experimental analysis of ERTS-1 imagery has demonstrated that remote sensing from space is a means of delineating and inventorying Ohio's strip-mined areas, detecting power plant smoke plumes, and proving the data necessary for periodically compiling land use maps for the entire state. The nature and extent of these problems throughout Ohio, how ERTS data can contribute to their solution, and estimates of the long term significance of these initial findings to overall resource management interests in Ohio are summarized

Orbital surveys and state resource management

The resource management implications of satellite earth resource surveys for the state of Ohio are discussed. Discussions cover environmental problems, planning future developments, and short- and long-range benefits of such resource management

Production of CO(a 3 Pi) and other metastable fragments by electron impact dissociation of CO2

Dissociative excitation of CO(a 3 Pi) and other metastable fragments such as O(5S) produced by electron impact on CO

Excitation of the metastable E(3 Sigma g plus) state of N2 by electron impact

The contribution of the N2(E(3 Sigma g plus)) state to the total metastable excitation function of N2 assessed on the basis of time-of-flight studies of metastable nitrogen molecules. The cross section for electron impact excitation state was determined in the domain of the resonance form threshold (11.87 eV) to an energy of about 13 eV. The maximum value of the cross section was found to be (7.0 + or - 4.0) x 10 to the -18th power sq cm at an energy of 12.2 eV. The measurement was made absolute by using the previously determined yield of the metastable detector, the lifetime of the E state, and by eliminating the energy spread in the electron beam from the raw data. The half-width (FWHM) of the resonance-like excitation function near threshold was found to be about 0.4 eV. No substantial evidence was obtained from the present data for the presence of the nonresonant part of the excitation function for the state studied

Drink wise, age well; reducing alcohol related harm among people over 50: a study protocol

Background: Evidence suggests that the use of alcohol among older adults (defined as those aged 50+) has increased in recent years, with people aged 55-64 now more likely to exceed the recommended weekly guidelines than any other age group. Methods/ design: This is a quasi-experimental study with a before-after design. A postal questionnaire will be sent to 76,000 people aged 50 and over registered with a general practice in five different 'demonstration' (intervention) and control areas in the UK. Multiple interventions will then be delivered in demonstration areas across the UK. At the end of the programme, a postal questionnaire will be sent to the same individuals who completed it pre-programme to establish if there has been a reduction in alcohol use, at-risk drinking and alcohol related problems. Qualitative interviews with clients and staff will explore how the interventions were experienced; how they may work to bring about change and to identify areas for practice improvements. Discussion: This study protocol describes a multi-level, multi-intervention prevention-to-treatment programme which aims to reduce alcohol-related harm in people aged 50 and over

Solar radiation observation stations with complete listing of data archived by the National Climatic Center, Asheville, North Carolina and initial listing of data not currently archived

A listing is provided of organizations taking solar radiation data, the 166 stations where observations are made, the type of equipment used, the form of the recorded data, and the period of operation of each station. Included is a listing of the data from 150 solar radiation stations collected over the past 25 years and stored by the National Climatic Center

Uterine Displacement

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Crystal structure of the yellow 1:2 molecular complex lumiflavin–bisnaphthalene-2,3-diol

In the first molecular complex of the physiologically active neutral form of isoalloxazine studied, lumiflavin–bisnaphthalene-2,3-diol, each flavin is sandwiched between two naphthalenediol molecules with extensive overlap but a moderately large (3·44 Å) spacing, indicating at most weak charge-transfer interaction and in agreement with the yellow colour of the complex, nearly the same as that of the parent lumiflavin