VHS notes

https://orc.library.atu.edu/atu_vhs003/1014/thumbnail.jp

The corporate venture dyad: a study of the impact of cultural distance on venture performance.

Even though corporate ventures (CVs) provide many benefits to established corporations, they continue to fail at a high rate. Whereas research supports that a corporation can gain a parenting advantage over its competitors (Campbell et al., 1995), there is no evidence to support that starting more CVs leads to more successful CVs. Parenting advantage theory postulates that if a corporation with a parenting advantage starts a venture then that venture will be more successful than if any of their competitors had started the same venture (Campbell et al., 1995). CVs are typified by dynamism and innovation, but established corporations have a duty to maximize shareholder returns while minimizing risks (Simon et al., 1999). The divergence of these two cultures can create cultural friction at the interface of the interacting corporate and venture managers. I analyzed these relationships to understand what impact cultural distance could have on CV performance. I found that an increase in corporate cultural distance is associated with a decrease in venture success. My findings suggest that even though a corporation may possess resources that could benefit its venture, that cultural distance between a parent and its venture could be inhibiting the transfer of these resources to its venture leading to lower levels of venture success

Gas tungsten arc welding in a microgravity environment: Work done on GAS payload G-169

GAS payload G-169 is discussed. G-169 contains a computer-controlled Gas Tungsten Arc Welder. The equipment design, problem analysis, and problem solutions are presented. Analysis of data gathered from other microgravity arc welding and terrestrial Gas Tungsten Arc Welding (GTAW) experiments are discussed in relation to the predicted results for the GTAW to be performed in microgravity with payload G-169

Urban Blazers: Fostering Children’s Innate Curiosity and Sense of Adventure

https://digitalcommons.pcom.edu/bridging_gaps2016/1007/thumbnail.jp

CD notes

https://orc.library.atu.edu/atu_cdda0011/1004/thumbnail.jp

Staphylococcal Superantigen (TSST-1) Mutant Analysis Reveals that T Cell Activation Is Required for Biological Effects in the Rabbit Including the Cytokine Storm

Staphylococcal superantigens (sAgs), such as toxic shock syndrome toxin 1 (TSST-1), induce massive cytokine production, which may result in toxic shock syndrome (TSS) and sepsis. Recently, we reported that in vitro studies in human peripheral blood mononuclear cells (PBMC) do not reflect the immunological situation of the host, because after exposure to superantigens (sAgs) in vivo, mononuclear cells (MNC) leave the circulation and migrate to organs, e.g., the spleen, liver and lung. Our experimental model of choice is the rabbit because it is comparable to humans in its sensitivity to sAg. T cell activation has been assessed by lymphocyte proliferation and IL-2 gene expression after in vivo challenge with TSST-1 and the mutant antigens; expression of the genes of proinflammatory cytokines were taken as indicators for the inflammatory reaction after the combined treatment with TSST-1 and LPS. The question as to whether the biological activities of TSST-1, e.g., lymphocyte extravasation, toxicity and increased sensitivity to LPS, are mediated by T cell activation or activation by MHC II-only, are unresolved and results are contradictory. We have addressed this question by studying these reactions in vivo, with two TSST-1 mutants: one mutated at the MHC binding site (G31R) with reduced MHC binding with residual activity still present, and the other at the T cell binding site (H135A) with no residual function detectable. Here, we report that the mutant G31R induced all the biological effects of the wild type sAg, while the mutant with non-functional TCR binding did not retain any of the toxic effects, proving the pivotal role of T cells in this system