Coping Difficulties After Hospitalization

Coping difficulties of 113 adults 3 weeks after hospital discharge were identified using the Post-Discharge Coping Difficulty Scale and a brief focused telephone interview (11-item guide). Overall, low difficulty scores were reported (M = 23.9, SD = 18.2, range = 0 to 100). Qualitative data reveal specific coping difficulties in the categories of stressors, specific difficulties, caring for self, managing the condition, family, advice needed, contact with the health care system, and what they wished they knew before discharge. A core theme of biographical reconstruction emerged

Primer Festival de Nuevo Teatro en Washington: Trayectoria y análisis

Primer Festival de Nuevo Teatro en Washington: Trayectoria y análisi

Utopian Projects and Crises of Theory: Describing the Elephant

Utopian Projects and Crises of Theory: Describing the Elephan

Cuba's Teatro Nuevo: First National Festival

Cuba's Teatro Nuevo: First National Festiva

A study of the reactions of eight mothers of post-adolescent schizophrenics to their child's improvement

Thesis (M.S.)--Boston Universit

Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E

The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~cient transport to the cell surface, where presented peptides are scanned by T lymphocytes. The function of the other class I molecules is in dispute. The human, nonclassical class I gene, HLA-E, was found to be ubiquitously transcribed, whereas cell surface expression was dif~cult to detect upon transfection. Pulse chase experiments revealed that the HLA-E heavy chain in transfectants, obtained with the murine myeloma cell line P3X63-Ag8.653 (X63), displays a significant reduction in oligosaccharide maturation and intracellular transport compared with HLA-B27 in corresponding transfectants. The accordingly low HLA-E cell surface expression could be significantly enhanced by either reducing the culture temperature or by supplementing the medium with human ~2m, suggesting inefficient binding of endogenous peptides to HLA-E. To analyze whether HLA-E binds peptides and to identify the corresponding ligands, fractions of acid-extracted material from HLA-E/X63 transfectants were separated by reverse phase HPLC and were tested for their ability to enhance HLA-E cell surface expression. Two fractions specifically increased the HLA class I expression on the HLA-E transfectant clone

The HLA-E Gene encodes two differentially regulated Transcripts and a Cell Surface Protein

An HLA-E-specific oligonucleotide probe was used to study the expressioonf HLA-E. This probed etects two HLA-E transcripts, 1.8 and 2.7 kb in size, which are present in varying ratios in allt issues and cell lines investigated. We demonstrate that alternative poly(A) site usage accounts for the differential regulation of the two HLA-E mRNA species. Sequence analysis of three cDNA clones, representing the two transcripts of HLA-E, and of anH LA-E gene encoded by cosmid cd3.14, revealed identity of gene and cDNA in the 3’ untranslated region. S1 nuclease protection assays confirmed that the two HLA-E transcripts are not alternative splicing products. Introduction of cd3.14, together with human ,&m into the murine myeloma cell line P3X63-Ag8.653, resulted in a cell surface expresosf ioan HLA-class I heavy chain detectablbey indirect immunofluorescence whereas transfection into the humBaznr n expressing mouse L cell line, 527 was negative with regard to cell surface expressionC. ell surface labeling of transfectants and immunoprecipitation with a monomorphic HLA class I-specific antibodyo r an antibody against human &m confirmed the presence of an HLA-E H chain on the cell surface. These results indicate that the HLA-E gene codes for a class I H chain that can be expressed on the cell surface

Integrating palliative care with intensive care for critically ill patients with lung cancer

With newer information indicating more favorable outcomes of intensive care therapy for lung cancer patients, intensivists increasingly are willing to initiate an aggressive trial of this therapy. Concerns remain, however, that the experience of the intensive care unit for patients with lung cancer and their families often may be distressing. Regardless of prognosis, all patients with critical illness should receive high-quality palliative care, including symptom control, communication about appropriate care goals, and support for both patient and family throughout the illness trajectory. In this article, we suggest strategies for integrating palliative care with intensive care for critically ill lung cancer patients. We address assessment and management of symptoms, knowledge and skill needed for effective communication, and interdisciplinary collaboration for patient and family support. We review the role of expert consultants in providing palliative care in the intensive care unit, while highlighting the responsibility of all critical care clinicians to address basic palliative care needs of patients and their families

Personality traits and health behaviors as predictors of subjective wellbeing among a multiethnic sample of university-attending emerging young adults

This study examines the relative contributions of individual characteristics of personality and health behaviors to subjective wellbeing among university-attending emerging young adults. Three dimensions of wellbeing were assessed: affective (positive affect), physical/mental (overall health), and cognitive (quality of life). The sample (N=599) consisted of students of various racial/ethnic backgrounds, including White/non-Hispanic, Hispanic/Latino, Asian/Pacific Islander, and Black/African American from a large public university in Southern California (28% male, 72% female; mean age = 20.85, SD = 1.84). Respondents completed the Student Health Survey, which consisted of items on basic demographics, substance use, health behaviors, Affect Balance Scale, Extraversion and Neuroticism subscales of the Big Five Taxonomy of Personality, Quality of Life scale, and an online food-intake survey for seven days. Descriptive statistics and bivariate correlations were calculated as preliminary analysis and hierarchical regression analyses were conducted to examine how each set of predictors contributes to the overall predictive ability and relative importance on subjective wellbeing. Extraverted individuals reported more positive affect and higher quality of life. Neuroticism was associated with less positive affect, poorer health, and lower quality of life. Physical activity was consistently associated with subjective wellbeing, accounting for 33%, 13%, and 32% of the total variance in positive affect, overall health, and quality of life, respectively. Findings indicate that health behaviors are important correlates of three dimensions of wellbeing over and above the effects of personality traits. Implications for designing health and wellness programs to improve the wellbeing and quality of life among young adults are discussed

Size and composition of consumer saving

Saving and investment ; Consumer behavior