Using Data to Drive State Improvement in Enrollment and Retention Performance

Outlines the RWJF Maximizing Enrollment program's core performance measures for Medicaid and Children's Health Insurance Program enrollment and retention, designed to assess state efforts to better utilize data to monitor and improve outreach and policy

A Sensitive Search for [N II]205 μm Emission in a z = 6.4 Quasar Host Galaxy

We present a sensitive search for the 3P1 → 3P0 ground-state fine structure line at 205 μm of ionized nitrogen ([N II]205μm) in one of the highest-redshift quasars (J1148+5251 at z = 6.42) using the IRAM 30 m telescope. The line is not detected at a (3σ) depth of 0.47 Jy km s^−1, corresponding to a [N II]205μm luminosity limit of L[N II] 7) using the Atacama Large Millimeter/submillimeter Array, for which the highly excited rotational transitions of CO will be shifted outside the accessible (sub-)millimeter bands

The synoptic regulation of dryline intensity

To investigate the role of synoptic-scale processes in regulating the strength of the dryline, a dataset is constructed of all drylines occurring within the West Texas Mesonet (WTM) during April, May, and June of 2004 and 2005. In addition, dewpoint and wind data were collected from stations on the western (Morton; MORT) and eastern (Paducah; PADU) periphery of the WTM domain (230 km across), generally oriented east–west across the typical location of the dryline in west Texas. Drylines were characterized by two variables: the difference in dewpoint between MORT and PADU (hereafter, dryline intensity) and the difference in the eastward component of the wind between MORT and PADU (hereafter, dryline conflu-ence). A high degree of correlation existed between the two variables, consistent with a strong role for dryline confluence in determining dryline intensity. Some cases departing from the strong correlation between these variables represent synoptically quiescent drylines whose strength is likely dominated by boundary layer mixing processes. Composite synoptic analyses were constructed of the upper and lower quartiles of dryline intensity, termed STRONG and WEAK, respectively. STRONG drylines were associated with a short-wave trough in the upper-level westerlies approaching west Texas, an accompanying surface cyclone over eastern Ne

Out of the Box: Football . . . With Robots?

Applying the fundamental concepts of engineering learned during their studies at Purdue University Calumet and South Bend, three students team up to describe their participation in the annual Intercollegiate Robotic Football competition at Notre Dame. Ben Weiss created a competitive quarterback while Zach Nava and Chris Markovich\u27s receiver joined the fray. Students who participate in competitions like this one are able to learn a broad range of skills in mechanical engineering, computer engineering, and electrical engineering

The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins

The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host. Ectopic expression of the interferon-induced 20-kDa exonuclease ISG20 suppressed replication of chikungunya virus and Venezuelan equine encephalitis virus, two mosquito-vectored RNA alphaviruses. Since the replication of alphavirus genomes occurs exclusively in the cytoplasm, the mechanism of nucleus-localized ISG20 inhibition of replication is unclear. In this study, we determined that ISG20 acts as a master regulator of over 100 genes, many of which are ISGs. Specifically, ISG20 upregulated IFIT1 genes and inhibited translation of the alphavirus genome. Furthermore, IFIT1-sensitive alphavirus replication was increased in Isg20−/− mice compared to the replication of wild-type viruses but not in cells ectopically expressing ISG20. We propose that ISG20 acts as an indirect regulator of RNA virus replication in the cytoplasm through the upregulation of many other ISGs.Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear. The 20-kDa ISG ISG20 is a nuclear 3′–5′ exonuclease with preference for single-stranded RNA (ssRNA) and has been implicated in the IFN-mediated restriction of several RNA viruses. Although the exonuclease activity of ISG20 has been shown to degrade viral RNA in vitro, evidence has yet to be presented that virus inhibition in cells requires this activity. Here, we utilized a combination of an inducible, ectopic expression system and newly generated Isg20−/− mice to investigate mechanisms and consequences of ISG20-mediated restriction. Ectopically expressed ISG20 localized primarily to Cajal bodies in the nucleus and restricted replication of chikungunya and Venezuelan equine encephalitis viruses. Although restriction by ISG20 was associated with inhibition of translation of infecting genomic RNA, degradation of viral RNAs was not observed. Instead, translation inhibition of viral RNA was associated with ISG20-induced upregulation of over 100 other genes, many of which encode known antiviral effectors. ISG20 modulated the production of IFIT1, an ISG that suppresses translation of alphavirus RNAs. Consistent with this observation, the pathogenicity of IFIT1-sensitive alphaviruses was increased in Isg20−/− mice compared to that of wild-type viruses but not in cells ectopically expressing ISG20. Our findings establish an indirect role for ISG20 in the early restriction of RNA virus replication by regulating expression of other ISGs that inhibit translation and possibly other activities in the replication cycle

Entanglement Sharing and Decoherence in the Spin-Bath

The monogamous nature of entanglement has been illustrated by the derivation of entanglement sharing inequalities - bounds on the amount of entanglement that can be shared amongst the various parts of a multipartite system. Motivated by recent studies of decoherence, we demonstrate an interesting manifestation of this phenomena that arises in system-environment models where there exists interactions between the modes or subsystems of the environment. We investigate this phenomena in the spin-bath environment, constructing an entanglement sharing inequality bounding the entanglement between a central spin and the environment in terms of the pairwise entanglement between individual bath spins. The relation of this result to decoherence will be illustrated using simplified system-bath models of decoherence.Comment: 5 pages, 1 figure v2: 6 pages 2 figures, additional example and reference

Diversity and environmental adaptation of phagocytic cell metabolism

Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation-key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils-heterogeneous cell populations possessing cell and tissue-specific functions of which cellular metabolism comprises a critical underpinning. Core functions of phagocytic cells are diverse and sensitive to alterations in environmental- and tissue-specific nutrients and growth factors. As phagocytic cells adapt to these extracellular cues, cellular processes are altered and may contribute to pathogenesis. The considerable degree of functional heterogeneity among monocyte, neutrophil, and other phagocytic cell populations necessitates diverse metabolism. As we review our current understanding of metabolism in phagocytic cells, gaps are focused on to highlight the need for additional studies that hopefully enable improved cell-based strategies for counteracting cancer and other diseases

Place of birth, duration of residence, neighborhood immigrant composition and body mass index in New York City

<p>Abstract</p> <p>Background</p> <p>Past research has suggested that changes in culture explain the substantial weight gain seen in many immigrant groups with length of residence in the U.S. and across generations of residence in the U.S. However, it has been theorized that those settling in immigrant and co-ethnic neighborhoods may be buffered against this acculturative process and will be more likely to maintain home country dietary and physical activity patterns. To investigate this theory we incorporated measures of neighborhood immigrant composition into analyses of individual's body mass index (BMI) and generation of immigration and duration of residence in the U.S.</p> <p>Methods</p> <p>Multilevel analyses were performed using objectively measured height and weight and survey data on diet and physical activity from a sample of 13,011 residents of New York City. Census data were used to calculate the proportion of foreign-born residents and extent of household linguistic isolation in a ½ mile radial buffer around the subject's home.</p> <p>Results</p> <p>Foreign birth was associated with a significantly lower BMI (-1.09 BMI units, P < 0.001). This association was weakest among Asians (-0.66 BMI units, P = 0.08) and strongest among Black-Caribbeans (-1.41 BMI units, P = 0.07). After controlling for individual level variables, neighborhood proportion foreign-born was not associated with BMI, but increasing neighborhood linguistic isolation was inversely associated with BMI among Hispanics (-2.97 BMI units, P = 0.03). Furthermore among Hispanics, the association between foreign birth and BMI was stronger in low linguistic isolation neighborhoods (-1.36 BMI units, P < 0.0001) as compared to in high linguistic isolation levels (-0.42 BMI units, P = 0.79). Increasing duration of residence in the U.S. was significantly associated with higher BMI overall and among Hispanics.</p> <p>Conclusion</p> <p>The analyses suggest that acculturation is associated with weight gain, and that neighborhood characteristics are only associated with BMI among Hispanics. However, we suggest that changes in body size currently interpreted as post-migration effects of acculturation to U.S. norms may in fact reflect changes in norms that are taking place internationally.</p

Evidence-Based Decision Making in Local Health Departments

Evidence-based decision making (EBDM) represents an important strategy to increase efficacy and efficiency of public health programs and practice. There is insufficient information on the application of EBDM among local health departments (LHDs). This qualitative study examined use of EBDM in New York State (NYS) LHDs and factors facilitating and impeding its adoption through interviews and focus groups with 47 LHD commissioners, health directors, and other upper-level staff. Findings suggest variability in application of EBDM in NYS LHDs. A number of internal factors (e.g., staff capacity, organizational culture) and external factors (e.g., policy environment, appropriate and replicable evidence-based models) contribute to its uneven use, even within a single LHD

First Detection of HCO+ Emission at High Redshift

We report the detection of HCO+(1-0) emission towards the Cloverleaf quasar (z=2.56) through observations with the Very Large Array. This is the first detection of ionized molecular gas emission at high redshift (z>2). HCO+ emission is a star formation indicator similar to HCN, tracing dense molecular hydrogen gas (n(H_2) ~= 10^5 cm^{-3}) within star-forming molecular clouds. We derive a lensing-corrected HCO+ line luminosity of L'(HCO+) = 3.5 x 10^9 K km/s pc^2. Combining our new results with CO and HCN measurements from the literature, we find a HCO+/CO luminosity ratio of 0.08 and a HCO+/HCN luminosity ratio of 0.8. These ratios fall within the scatter of the same relationships found for low-z star-forming galaxies. However, a HCO+/HCN luminosity ratio close to unity would not be expected for the Cloverleaf if the recently suggested relation between this ratio and the far-infrared luminosity were to hold. We conclude that a ratio between HCO+ and HCN luminosity close to 1 is likely due to the fact that the emission from both lines is optically thick and thermalized and emerges from dense regions of similar volumes. The CO, HCN and HCO+ luminosities suggest that the Cloverleaf is a composite AGN--starburst system, in agreement with the previous finding that about 20% of the total infrared luminosity in this system results from dust heated by star formation rather than heating by the AGN. We conclude that HCO+ is potentially a good tracer for dense molecular gas at high redshift.Comment: 5 pages, 3 figures, ApJL, in press (accepted May 17, 2006