Coherent Transport through an interacting double quantum dot: Beyond sequential tunneling

Various causes for negative differential conductance in transport through an interacting double quantum dot are investigated. Particular focus is given to the interplay between the renormalization of the energy levels due to the coupling to the leads and the decoherence of the states. The calculations are performed within a basis of many-particle eigenstates and we consider the dynamics given by the von Neumann-equation taking into account also processes beyond sequential tunneling. A systematic comparison between the levels of approximation and also with different formalisms is performed. It is found that the current is qualitatively well described by sequential processes as long as the temperature is larger than the level broadening induced by the contacts.Comment: 11 pages, 5 figures included in tex

Elastomeric actuator devices for magnetic resonance imaging

The present invention is directed to devices and systems used in magnetic imaging environments that include an actuator device having an elastomeric dielectric film with at least two electrodes, and a frame attached to the actuator device. The frame can have a plurality of configurations including, such as, for example, at least two members that can be, but not limited to, curved beams, rods, plates, or parallel beams. These rigid members can be coupled to flexible members such as, for example, links wherein the frame provides an elastic restoring force. The frame preferably provides a linear actuation force characteristic over a displacement range. The linear actuation force characteristic is defined as .+-.20% and preferably 10% over a displacement range. The actuator further includes a passive element disposed between the flexible members to tune a stiffness characteristic of the actuator. The passive element can be a bi-stable element. The preferred embodiment actuator includes one or more layers of the elastomeric film integrated into the frame. The elastomeric film can be made of many elastomeric materials such as, for example, but not limited to, acrylic, silicone and latex

Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis

Variability and modification of the symptoms of Huntington’s disease (HD) are commonly observed in both patient populations and animal models of the disease. Utilizing a stable line of the R6/2 HD mouse model, the present study investigated the role of genetic background in the onset and severity of HD symptoms in a transgenic mouse. R6/2 congenic C57BL/6J and C57BL/6J × DBA/2J F1 (B6D2F1) mice were evaluated for survival and a number of behavioral phenotypes. This study reports that the presence of the DBA/2J allele results in amelioration or exacerbation of several HD-like phenotypes characteristic of the R6/2 mouse model and indicates the presence of dominant genetic modifiers of HD symptoms. This study is the first step in identifying genes that confer natural genetic variation and modify the HD symptoms. This identification may lead to novel targets for treatment and help elucidate the molecular mechanisms of HD pathogenesis

Drag-Based CME Modeling With Heliospheric Images Incorporating Frontal Deformation : ELEvoHI 2.0

The evolution and propagation of coronal mass ejections (CMEs) in interplanetary space is still not well understood. As a consequence, accurate arrival time and arrival speed forecasts are an unsolved problem in space weather research. In this study, we present the ELlipse Evolution model based on HI observations (ELEvoHI) and introduce a deformable front to this model. ELEvoHI relies on heliospheric imagers (HI) observations to obtain the kinematics of a CME. With the newly developed deformable front, the model is able to react to the ambient solar wind conditions during the entire propagation and along the whole front of the CME. To get an estimate of the ambient solar wind conditions, we make use of three different models: Heliospheric Upwind eXtrapolation model (HUX), Heliospheric Upwind eXtrapolation with time dependence model (HUXt), and EUropean Heliospheric FORecasting Information Asset (EUHFORIA). We test the deformable front on a CME first observed in STEREO-A/HI on February 3, 2010 14:49 UT. For this case study, the deformable front provides better estimates of the arrival time and arrival speed than the original version of ELEvoHI using an elliptical front. The new implementation enables us to study the parameters influencing the propagation of the CME not only for the apex, but for the entire front. The evolution of the CME front, especially at the flanks, is highly dependent on the ambient solar wind model used. An additional advantage of the new implementation is given by the possibility to provide estimates of the CME mass.Peer reviewe

NIR Imaging Spectroscopy of the Inner Few Arcseconds of NGC 4151 with OSIRIS at Keck

We present H- and K-band data from the inner arcsecond of the Seyfert 1.5 galaxy NGC 4151 obtained with the adaptive optics assisted near-infrared imaging field spectrograph OSIRIS at the Keck Observatory. The angular resolution is about a few parsecs on-site and thus competes easily with optical images taken previously with the Hubble Space Telescope. We present the morphology and dynamics of most species detected but focus on the morphology and dynamics of the narrow line region (as traced by emission of [FeII]1.644 m), the interplay between plasma ejected from the nucleus (as traced by 21 cm continuum radio data) and hot H2 gas and characterize the detected nuclear HeI2.058 m absorption feature as a narrow absorption line (NAL) phenomenon. Emission from the narrow line region (NLR) as traced by [FeII] reveals a biconical morphology and we compare the measured dynamics in the [FeII] emission line with models proposing acceleration of gas in the NLR and simple ejection of gas into the NLR. In the inner 2.5 arcseconds the acceleration model reveals a better fit to our data than the ejection model.We also see evidence that the jet very locally enhances emission in [FeII] at certain positions in our field-of-view such that we were able to distinct the kinematics of these clouds from clouds generally accelerated in the NLR. Further, the radio jet is aligned with the bicone surface rather than the bicone axis such that we assume that the jet is not the dominant mechanism responsible for driving the kinematics of clouds in the NLR. The hot H2 gas is thermal with a temperature of about 1700 K. We observe a remarkable correlation between individual H2 clouds at systemic velocity with the 21 cm continuum radio jet. We propose that the radio jet is at least partially embedded in the galactic disk of NGC 4151 such that deviations from a linear radio structure are invoked by interactions of jet plasma with H2 clouds that are moving into the path of the jet because of rotation of the galactic disk of NGC 4151. Additionally, we observe a correlation of the jet as traced by the radio data, with gas as traced in Br and H2, at velocities between systemic and +/- 200 km/s at several locations along the path of the jet. The HeI2.058 m line in NGC 4151 appears in emission with a blueshifted absorption component from an outflow. The emission (absorption) component has a velocity offset of 10 km/s (-280 km/s) with a Gaussian (Lorentzian) full-width (half-width) at half maximum of 160 km/s (440 km/s). The absorption component remains spatially unresolved and its kinematic measures differ from that of UV resonance absorption lines. From the amount of absorption we derive a lower limit of the HeI 2S column density of 1 10(exp 14) cm2 with a covering factor along the line-of-sight of C(sub los) approximately equal to 0.1

Platelet-derived extracellular vesicles in Huntington's disease.

The production and release of extracellular vesicles (EV) is a property shared by all eukaryotic cells and a phenomenon frequently exacerbated in pathological conditions. The protein cargo of EV, their cell type signature and availability in bodily fluids make them particularly appealing as biomarkers. We recently demonstrated that platelets, among all types of blood cells, contain the highest concentrations of the mutant huntingtin protein (mHtt)-the genetic product of Huntington's disease (HD), a neurodegenerative disorder which manifests in adulthood with a complex combination of motor, cognitive and psychiatric deficits. Herein, we used a cohort of 59 HD patients at all stages of the disease, including individuals in pre-manifest stages, and 54 healthy age- and sex-matched controls, to evaluate the potential of EV derived from platelets as a biomarker. We found that platelets of pre-manifest and manifest HD patients do not release more EV even if they are activated. Importantly, mHtt was not found within EV derived from platelets, despite them containing high levels of this protein. Correlation analyses also failed to reveal an association between the number of platelet-derived EV and the age of the patients, the number of CAG repeats, the Unified Huntington Disease Rating Scale total motor score, the Total Functional Capacity score or the Burden of Disease score. Our data would, therefore, suggest that EV derived from platelets with HD is not a valuable biomarker in HD.The study was funded by an operating grant from the Merck Sharpe & Dohme to F.C. who is also a recipient of a National Researcher career award from the Fonds de Recherche du Québec en santé (FRQS) providing salary support and operating funds. I.S.-A. was supported by a CIHR-Huntington Society of Canada postdoctoral fellowship. R.A.B. and S.L.M. are supported by a National Institute for Health Research (NIHR) award of a Biomedical Research Center to the University of Cambridge and Addenbrooke’s Hospital. E.B. is supported by the Canadian Institutes of Health Research. N.D. MD-MSc. also funded by CIHR and by Canadian Consortium on Neurodegeneration in Aging (CCNA). HLD and JPL hold a Desjardins scholarship from the Fondation du CHU de Québec. HLD hold a bourse d’excellence du Centre Thématique de Recherche en Neurosciences (CTRN) du CHU de Québec. The authors would like to thank all the students and staff who helped with the blood collections in Cambridge, Quebec City and Montreal and importantly, all patients and their families for being so generous with their time in participating to this stud

Prediction of the in situ coronal mass ejection rate for solar cycle 25: Implications for Parker Solar Probe in situ observations

The Parker Solar Probe (PSP) and Solar Orbiter missions are designed to make groundbreaking observations of the Sun and interplanetary space within this decade. We show that a particularly interesting in situ observation of an interplanetary coronal mass ejection (ICME) by PSP may arise during close solar flybys ($< 0.1$~AU). During these times, the same magnetic flux rope inside an ICME could be observed in situ by PSP twice, by impacting its frontal part as well as its leg. Investigating the odds of this situation, we forecast the ICME rate in solar cycle 25 based on 2 models for the sunspot number (SSN): (1) the forecast of an expert panel in 2019 (maximum SSN = 115), and (2) a prediction by McIntosh et al. (2020, maximum SSN = 232). We link the SSN to the observed ICME rates in solar cycles 23 and 24 with the Richardson and Cane list and our own ICME catalog, and calculate that between 1 and 7 ICMEs will be observed by PSP at heliocentric distances $< 0.1$ AU until 2025, including 1$\sigma$ uncertainties. We then model the potential flux rope signatures of such a double-crossing event with the semi-empirical 3DCORE flux rope model, showing a telltale elevation of the radial magnetic field component $B_R$, and a sign reversal in the component $B_N$ normal to the solar equator compared to field rotation in the first encounter. This holds considerable promise to determine the structure of CMEs close to their origin in the solar corona.Comment: 11 pages, 6 figures, accepted for publication in the Astrophysical Journal on 2020 September 1