Supplementray Figures

Figure S1. The mechanistic diagram of the study. A mechanistic diagram of rosiglitazone reversing hypoxia-induced trophoblast ferroptosis via PPARγ was built by Figdraw software and Adobe Illustrator 2020. RRARγ, which binds to RXRα, could regulate lipid peroxidation and lipid synthesis by promoting Nrf2 and inhibiting SREBP1. Hypoxia intervention could inhibit RRARγ, thereby promoting lipid peroxidation and lipid synthesis to induce ferroptosis in HTR-8/Svneo cells (A). Rosiglitazone reversed hypoxia-induced ferroptosis by upregating RRARγ (B). Figure S2. GPx4 expression is independent of SREBP1. In HTR-8/SVneo cells, SREBP1 silencing did not affect GPx4 mRNA and protein expression. *P<0.05 vs the NC group, one-way ANOVA.</p

Concordance of tomographic ultrasound and multiplanar ultrasound in detecting levator ani muscle injury in patients with pelvic organ prolapse.

AIM:To compare the evaluations of evaluate levator ani muscle injury (LAMI) by tomographic ultrasound imaging (TUI) and multiplanar (MP) ultrasound in patients with pelvic organ prolapse (POP). METHOD:This retrospective analysis studied women who underwent International Continence Society POP quantification examination between October 2015 and June 2016. LAMI was assessed by both TUI and MP ultrasounds. Concordance of these two testing results was analyzed. Their correlations with clinical symptoms were also studied. RESULTS:A total of 135 women were included. All the patients with POP had a minimal LAMI depth ≥ 7 mm. Two examinations, TUI and MP, had satisfactory concordance (k = 0.71, P < 0.01). Depth of LAMI in the coronal plane demonstrated good agreement with TUI scores (r = 0.84; P < 0.01). After controlling for age, BMI, and parity, to have clinically significant POP and POP symptoms, the odds ratios (ORs) for the depth of LAMI in the coronal plane were 1.31 (95% CI 1.19-1.44) and 1.25 (95% CI 1.14-1.36), and for TUI scores were 1.72 (95% CI 1.37-2.17) and 1.63 (95% CI 1.31-2.03). Receiver operating characteristic curve analyses showed a cutoff depth of 7 mm of LAMI yielded a sensitivity of 62% and specificity of 80% for POP symptoms. CONCLUSIONS:TUI and MP had satisfactory concordance in detecting LAMI and correlated with clinical symptoms of POP

From Technical to Aesthetics Quality Assessment and Beyond:Challenges and Potential

Every day 1.8+ billion images are being uploaded to Facebook, Instagram, Flickr, Snapchat, and WhatsApp [6]. The exponential growth of visual media has made quality assessment become increasingly important for various applications, from image acquisition, synthesis, restoration, and enhancement, to image search and retrieval, storage, and recognition. There have been two related but different classes of visual quality assessment techniques: image quality assessment (IQA) and image aesthetics assessment (IAA). As perceptual assessment tasks, subjective IQA and IAA share some common underlying factors that affect user judgments. Moreover, they are similar in methodology (especially NR-IQA in-the-wild and IAA). However, the emphasis for each is different: IQA focuses on low-level defects e.g. processing artefacts, noise, and blur, while IAA puts more emphasis on abstract and higher-level concepts that capture the subjective aesthetics experience, e.g. established photographic rules encompassing lighting, composition, and colors, and personalized factors such as personality, cultural background, age, and emotion. IQA has been studied extensively over the last decades [3, 14, 22]. There are three main types of IQA methods: full-reference (FR), reduced-reference (RR), and no-reference (NR). Among these, NRIQA is the most challenging as it does not depend on reference images or impose strict assumptions on the distortion types and level. NR-IQA techniques can be further divided into those that predict the global image score [1, 2, 10, 17, 26] and patch-based IQA [23, 25], naming a few of the more recent approaches.publishe

Left image depicts an intact levator ani (LA) muscle on right side (short white arrows) and a left-sided avulsion in coronal plane (long white arrows), and the measurement of the levator ani muscle injury (LAMI) depth (long white arrows) above the minimal axial plane in the coronal plane (reference line is the white horizontal line).

<p>Right image depicts levator avulsion on the left side in slices 3–8 on tomographic ultrasound imaging (TUI). TUI score of the right side is 0 and 6 on the left side. P: symphysis pubis.</p

Concordance of tomographic ultrasound and multiplanar ultrasound in detecting levator ani muscle injury in patients with pelvic organ prolapse

<div><p>Aim</p><p>To compare the evaluations of evaluate levator ani muscle injury (LAMI) by tomographic ultrasound imaging (TUI) and multiplanar (MP) ultrasound in patients with pelvic organ prolapse (POP).</p><p>Method</p><p>This retrospective analysis studied women who underwent International Continence Society POP quantification examination between October 2015 and June 2016. LAMI was assessed by both TUI and MP ultrasounds. Concordance of these two testing results was analyzed. Their correlations with clinical symptoms were also studied.</p><p>Results</p><p>A total of 135 women were included. All the patients with POP had a minimal LAMI depth ≥ 7 mm. Two examinations, TUI and MP, had satisfactory concordance (<i>k</i> = 0.71, <i>P</i> < 0.01). Depth of LAMI in the coronal plane demonstrated good agreement with TUI scores (<i>r</i> = 0.84; <i>P</i> < 0.01). After controlling for age, BMI, and parity, to have clinically significant POP and POP symptoms, the odds ratios (ORs) for the depth of LAMI in the coronal plane were 1.31 (95% CI 1.19–1.44) and 1.25 (95% CI 1.14–1.36), and for TUI scores were 1.72 (95% CI 1.37–2.17) and 1.63 (95% CI 1.31–2.03). Receiver operating characteristic curve analyses showed a cutoff depth of 7 mm of LAMI yielded a sensitivity of 62% and specificity of 80% for POP symptoms.</p><p>Conclusions</p><p>TUI and MP had satisfactory concordance in detecting LAMI and correlated with clinical symptoms of POP.</p></div

Concordance of tomographic ultrasound and multiplanar ultrasound in detecting levator ani muscle injury in patients with pelvic organ prolapse - Fig 1

<p>Multiplanar mode depicting three orthogonal planes of normal levator ani (LA) insertion: midsagittal plane (top left); coronal plane (top right); and axial plane (bottom left). Determination of the minimal axial plan according to anteroposterior diameter (double-sided arrow) in the midsagittal plane (top left). Image of the intact crescent-shape LA muscles (white arrows) in the coronal plane (top left). P: symphysis pubis.</p

Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm.

Although 5-fluorouracil (5-Fu) combination chemotherapy provides a satisfactory therapeutic response in patients with gestational trophoblastic neoplasms (GTNs), it has severe side effects. The current study analyzed the therapeutic effects and side effects of tegafur plus actinomycin D (Act-D) vs. 5-Fu plus Act-D for the treatment of GTNs based on controlled historical records. A total of 427 GTN cases that received tegafur and Act-D combination chemotherapy at the Second Xiangya Hospital of XiangYa Medical School between August 2003 and July 2013 were analyzed based on historical data. A total of 393 GTN cases that received 5-Fu plus Act-D between August 1993 and July 2003 at the same hospital were also analyzed, which constituted the control group. The therapeutic effects, toxicity and side effects after chemotherapy were compared between the groups. The overall response rate was 90.63% in the tegafur+Act-D group (tegafur group) and 92.37% in the 5-Fu+Act-D group (5-Fu group); these rates were not significantly different (P > 0.05). However, the incidence rates of myelosuppression (white blood cell decline), gastrointestinal reactions (nausea, vomiting, dental ulcer, and diarrhea), skin lesions and phlebitis were lower in the tegafur group than in the 5-Fu group (P < 0.05). The results of this study may provide useful data for the clinical application of tegafur in GTN treatment