1,023 research outputs found

    Somatostatin: Diverse Physiological Roles and Therapeutic Implications

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    In its brief lifetime as a known peptide, somatostatin has provided a truly remarkable story filled with surprising developments from unexpected quarters. The foundation was set in 1969, when Krulich and McCann reported that fractions of a crude hypothalamic extract inhibited the secretion of growth hormone. In 1973, Guillemin\u27s laboratory reported the sequence and synthesis of a fourteen amino acid peptide with the same inhibitory effect. It occurs in both a cyclic and linear form, each displaying equal biological activity. Somatostatin was assigned as its name, but it is also commonly referred to as growth hormone release inhibitory factor (GHRIF) or somatotropin-release inhibiting factor (SRIF)

    English historical novels on the first century A.D. as reflecting the trends of religious thought during the nineteenth and twentieth centuries

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    1. The Outside Tradition • 2. The Novel on Early Christian Times 1820-1850 • 3. The Early Christian Novel Ehters Controversy • 4. The Imaginative Approach to the New Testament Outside the Novel • 5. The Early Christian Romancers, 1860-1900 • 6. Modernism, and the Reconstruction of a Point of view Towards Christian Origins • 7. The First Two Decades of the Twentieth Century • 8. Novels, mostly of Scepticism, 1920-1939 • 9. Novels, chiefly of Belief, 1940-1955 • 10. The Continuing Outside Traditio

    An Appreciation of Robert Turner

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    Induction of remission in diabetes by lowering blood glucose

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    As diabetes continues to grow as major health problem, there has been great progress in understanding the important role of pancreatic beta-cells in its pathogenesis. Diabetes develops when the normal interplay between insulin secretion and the insulin sensitivity of target tissues is disrupted. With type 2 diabetes (T2D), glucose levels start to rise when beta-cells are unable to meet the demands of insulin resistance. For type 1 diabetes (T1D) glucose levels rise as beta-cells are killed off by autoimmunity. In both cases the increased glucose levels have a toxic effect on beta-cells. This process, called glucose toxicity, has a major inhibitory effect on insulin secretion. This beta-cell dysfunction can be reversed by therapies that reduce glucose levels. Thus, it is becoming increasingly apparent that an opportunity exists to produce a complete or partial remission for T2D, both of which will provide health benefit

    Some exact solutions in the one-dimensional unsteady motion of a gas

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    In this thesis, we present certain exact solutions of the mathematical equations governing the one-dimensional unsteady flow of a compressible fluid. In Chapter 2 we introduce the well-known simplification of the equations (1.1.10), (1.1.11) and (1.1.12) which occurs when the entropy is assumed to be constant, and conditions for parching solutions of the equations along characteristics are obtained. These results are used to generalise a problem solved by Mackie. In chapter 3 we meet the concept of a shook, and exact solutions are obtained for two problems in which shocks occur in non-uniform flows. In chapter 4 the case of waves in shallow water which has differential equations similar to those of gas flow is discussed. The results of the previous section are applied to this case and a problem attacked which permits a comparison to be made of the results obtained by this theory and a simpler linearized theory. Finally in chapter 5 we examine a method introduced by Martin for dealing with certain non-isentropic flows. Some new exact solutions of non-isentropic flows are thus obtained
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