“Soft” policing at hot spots—do police community support officers work? A randomized controlled trial

© 2016, The Author(s). Objectives: To determine whether crime-reduction effects of increased police patrols in hot spots are dependent on the “hard” threat of immediate physical arrest, or whether “soft” patrols by civilian (but uniformed) police staff with few arrest powers and no weapons can also reduce crime. We also sought to assess whether the number of discrete patrol visits to a hot spot was more or less important than the total minutes of police presence across all visits, and whether effects based on counts of crime would be consistent with effects on a Crime Harm Index outcome. Methods: We randomly assigned 72 hot spots into 34 treatment units and 38 controls. Treatment consisted of increases in foot patrol by uniformed, unarmed, Police Community Support Officers (PCSOs) who carry no weapons and hold few arrest powers beyond those of ordinary citizens. GPS-trackers on every PCSO and Constable in the city yielded precise measurements of all patrol time in all hot spots. Standardized mean differences (Cohen’s d), OLS regression model, and Weighted Displacement Quotient are used to assess main effects, to model the interaction effect of GPS data with treatment, and to measure the diffusion-of-benefits of the intervention, respectively. Outcomes included counts of incidents as well as the Cambridge Crime Harm Index. Results: As intended, patrol visits and minutes by Police Constables were equal across the treatment and control groups. The sole difference in policing between the treatments groups was in visits to the hot spots by PCSOs, in both the mean daily frequency of discrete visits (T = 4.65, C = 2.66; p ≤.001) and total minutes across all visits (T = 37.41, C = 15.92; p ≤.001), approximately two more ten-minute visits per day in treatment than in control. Main effect estimates suggest 39 % less crime by difference-in-difference analysis of reported crimes compared to control conditions, and 20 % reductions in emergency calls-for-service compared to controls. Crime in surrounding areas showed a diffusion of benefits rather than displacement for treatment hot spots compared to controls. A “Reiss’s Reward” effect was observed, with more proactive patrols predicting less crime across treatment hot spots, while more reactive PCSO time predicted more crime across control hot spots. Crime Harm Index estimates of the seriousness value of crime prevented ranged from 85 to 360 potential days of imprisonment in each treatment group hot spot (relative to controls) by a mean difference of 21 more minutes of PCSO patrol per day, for a potential return on investment of up to 26 to 1. Conclusions: A crime reduction effect of extra patrols in hot spots is not conditional on “hard” police power. Even small differences in foot patrols showing the “soft power” of unarmed paraprofessionals, holding constant vehicular patrols by Police Constables, were causally linked to both lower counts of crimes and a substantially lower crime harm index score. Correlational evidence within the treatment group suggests that greater frequency of discrete PCSO visits may yield more crime reduction benefit than greater duration of those visits, but RCTs are needed for better evidence on this crucial issue

Understanding the Effects of Lactose Hydrolysis Modeling on the Main Oligosaccharides in Goat Milk Whey Permeate.

Enzymatic hydrolysis of lactose is a crucial step to improve the efficiency and selectivity of membrane-based separations toward the recovery of milk oligosaccharides free from simple sugars. Response surface methodology was used to investigate the effects temperature (25.9 to 54.1 °C) and amount of enzyme (0.17 to 0.32% w/w) at 1, 2, and 4 h of reaction on the efficiency of lactose hydrolysis by Aspergillus oryzae β-galactosidase, preservation of major goat whey oligosaccharides, and on the de-novo formation of oligosaccharides. Lactose hydrolysis above 99% was achieved at 1, 2, and 4 h, not being significantly affected by temperature and amount of enzyme within the tested conditions. Formation of 4 Hexose (Hex) and 4 Hex 1 Hex and an increased de-novo formation of 2 Hex 1 N-Acetyl-Neuraminic Acid (NeuAc) and 2 Hex 1 N-Glycolylneuraminic acid (NeuGc) was observed in all treatments. Overall, processing conditions using temperatures ≤40 °C and enzyme concentration ≤0.25% resulted in higher preservation/formation of goat whey oligosaccharides

Reducing the Harm of Intimate Partner Violence: Randomized Controlled Trial of the Hampshire Constabulary CARA Experiment

Research Question: Among Southampton-area males arrested for and admitting to low-risk intimate partner violence as a first domestic offence and receiving a conditional caution, did a randomly assigned requirement to attend (with 5 to 7 other male offenders), two weekend day-long Cautioning and Relationship Abuse (CARA) workshops led by experienced professionals reduce the total severity of crime harm relative to a no-workshop control group? Data: Eligible offenders (N =293) were randomly assigned to the CARA workshop attendance requirement (n= 154) or to the no-workshop requirement (n = 139), with 91% of all cases receiving treatment as randomly assigned. Each offender’s records of police contact were tracked for exactly 365 days after the date of random assignment. Methods: All repeat arrests or complaints of crime naming the 293 randomly assigned offenders were coded by the Cambridge Crime Harm Index (CHI) as the primary outcome measure for each offender (Sherman et al 2016), with the sum of total days of recommended imprisonment for each offence (as the guideline starting point for sentencing) summed across all new offences, with both domestic and non-domestic relationships to their victims. Prevalence and frequency of repeat contact were also computed. All analysis was done by intention-to-treat. Findings: Offenders assigned to the workshop group were re-arrested for crimes with a total Crime Harm Index (CHI) value that was 27% lower than for re-arrests of offenders assigned to the control group (P =.011). The CARA workshop group members were arrested for crimes totalling an average of 8.4 days of recommended imprisonment under English sentencing guidelines, compared to an average of 11.6 days per offender assigned to the control group, the equivalent of 38% more harm without the workshop than with it. The effect size was much stronger, however, in the first study period of high caseflow (72% reduction in CHI, P = .001) than in the second period (21% reduction in CHI, P =.178). Frequency of re-arrest for domestic abuse (21% lower for workshop-assigned group) and prevalence (35% lower for workshop-assigned group) also favoured the CARA workshop group. Conclusions: The results of this one-year followup analysis suggest that the CARA workshops are an effective way to reduce the future harm of domestic abuse among first offenders who admit their crime, although effect size may vary over time. Given the highly restrictive eligibility criteria for the programme, these findings provide an evidence-based reason for testing the same treatment among a larger proportion of all first-offender arrests for domestic abuse. Keywords Intimate partner violence – policing – RCT—Crime Harm Index--CAR

COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults

The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer’s disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aβ-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults

Longitudinal trajectories in cortical thickness and volume atrophy: Superior cognitive performance does not protect against brain atrophy in older adults

Background: Previous research has identified a small subgroup of older adults that maintain a high level of cognitive functioning well into advanced age. Investigation of those with superior cognitive performance (SCP) for their age is important, as age-related decline has previously been thought to be inevitable. Objective: Preservation of cortical thickness and volume was evaluated in 76 older adults with SCP and 100 typical older adults (TOAs) assessed up to five times over six years. Methods: Regions of interest (ROIs) found to have been associated with super-aging status (a construct similar to SCP status) in previous literature were investigated, followed by a discovery phase analyses of additional regions. SCPs were aged 70 + at baseline, scoring at/above normative memory (CVLT-II) levels for demographically similar individuals aged 30–44 years old, and in the unimpaired range for all other cognitive domains over the course of the study. Results: In linear mixed models, following adjustment for multiple comparisons, there were no significant differences between rates of thinning or volume atrophy between SCPs and TOAs in previously identified ROIs, or the discovery phase analyses. With only amyloid-β negative individuals in the analyses, again there were no significant differences between SCPs and TOAs. Conclusion: The increased methodological rigor in classifying groups, together with the influence of cognitive reserve, are discussed as potential factors accounting for our findings as compared to the extant literature on those with superior cognitive performance for their age

SPON1 is associated with amyloid-β and APOE ϵ4-related cognitive decline in cognitively normal adults

Background: Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer\u27s disease. Objective: The aim of this study was to assess whether the association was present in cognitively normal older adults. Methods: Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study. Results: No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE) ϵ4 and rs11023139 in individuals with high amyloid-β burden. APOE ϵ4/rs11023139-A carriers declined significantly faster than APOE ϵ4/rs11023139-G-G carriers in measures of global cognition (p=0.011) and verbal episodic memory (p=0.020). Conclusion: These results suggest that carriage of the Spondin-1 rs11023139-A allele significantly contributes to a worsening of cognitive performance in APOE ϵ4 cognitively normal older adults with a high neocortical amyloid-β burden

Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid b (Ab) deposition (Ab1) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Ab-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n 5 172) and cognitively normal for age (n 5 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Ab status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Ab1. Rates of age- and Ab-associated atrophy did not differ between the groups on any measure. Ab2 individuals displayed the slowest rates of atrophy. Discussion: Maintenance of superior memory in late life does not reflect resistance to age- or Abassociated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Ab deposition (i.e. Ab2) displayed reduced rates of cortical atrophy

Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle study of ageing

Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer\u27s disease (AD) risk. However, no study to-date has examined the relationship between MeDi adherence and accumulation of cerebral Aβ-amyloid (Aβ; a pathological hallmark of AD) in older adults. Cognitively normal healthy control participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing completed the Cancer Council of Victoria Food Frequency Questionnaire at baseline, which was used to construct a MeDi score for each participant (score range 0-9; higher score indicating higher adherence). Cerebral Aβ load was quantified by Pittsburgh Compound B positron emission tomography at baseline, 18 and 36 months: Only individuals categorised as Aβ accumulators , and thus considered to be on the AD pathway, were included in the analysis (N = 77). The relationship between MeDi adherence, MeDi components, and change in cerebral Aβ load (baseline to 36 months) was evaluated using Generalised Linear Modelling, accounting for age, gender, education, Apolipoprotein E ε4 allele status, body mass index and total energy intake. Higher MeDi score was associated with less Aβ accumulation in our cohort (β = -0.01 ± 0.004, p = 0.0070). Of the individual MeDi score components, a high intake of fruit was associated with less accumulation of Aβ (β = -0.04 ± 0.01, p = 0.00036). Our results suggest MeDi adherence is associated with reduced cerebral AD pathology accumulation over time. When our results are considered collectively with previous data linking the MeDi to slower cognitive decline, it is apparent that MeDi adherence warrants further investigation in the quest to delay AD onset

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross‐PIA white paper that provides both a concise "state-of-the-science" report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations

Fifteen years of the Australian imaging, biomarkers and lifestyle (AIBL) study: Progress and observations from 2,359 older adults spanning the spectrum from cognitive normality to Alzheimer\u27s disease

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer\u27s disease dementia (AD)) as an \u27Inception cohort\u27 who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an \u27Enrichment cohort\u27 (as of 10 April 2019). Objective: Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation. Methods: Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance imaging, MRI; positron emission tomography, PET), biofluid biomarkers and lifestyle evaluations. Results: AIBL has made major contributions to the understanding of the natural history of AD, with cognitive and biological definitions of its three major stages: preclinical, prodromal and clinical. Early deployment of Aβ-amyloid and tau molecular PET imaging and the development of more sensitive and specific blood tests have facilitated the assessment of genetic and environmental factors which affect age at onset and rates of progression. Conclusion: This fifteen-year study provides a large database of highly characterized individuals with longitudinal cognitive, imaging and lifestyle data and biofluid collections, to aid in the development of interventions to delay onset, prevent or treat AD. Harmonization with similar large longitudinal cohort studies is underway to further these aims