Increasing but Variable Trend of Surface Ozone in the Yangtze River Delta Region of China

Surface ozone (O-3) increased by similar to 20% in the Yangtze River Delta (YRD) region of China during 2014-2020, but the aggravating trend is highly variable on interannual time and city-level space scales. Here, we employed multiple air quality observations and numerical simulation to describe the increasing but variable trend of O-3 and to reveal the main driving factors behind it. In 2014-2017, the governmental air pollution control action plan was mostly against PM2.5 (mainly to control the emissions of SO2, NOx, and primary PM2.5) and effectively reduced the PM2.5 concentration by 18%-45%. However, O-3 pollution worsened in the same period with an increasing rate of 4.9 mu g m(-3) yr(-1), especially in the Anhui province, where the growth rate even reached 14.7 mu g m(-3) yr(-1). After 2018, owing to the coordinated prevention and control of both PM2.5 and O-3, volatile organic compound (VOC) emissions in the YRD region has also been controlled with a great concern, and the O-3 aggravating trend in the same period has been obviously alleviated (1.1 mu g m(-3) yr(-1)). We further combined the precursor concentration and the corresponding O-3 formation regime to explain the observed trend of O-3 in 2014-2020. The leading O-3 formation regime in 2014-2017 is diagnosed as VOC-limited (21%) or mix-limited (58%), with the help of a simulated indicator HCHO/NOy. Under such condition, the decreasing NO2 (2.8% yr(-1)) and increasing VOCs (3.6% yr(-1)) in 2014-2017 led to a rapid increment of O-3. With the continuous reduction in NOx emission and further in ambient NOx/VOCs, the O-3 production regime along the Yangtze River has been shifting from VOC-limited to mix-limited, and after 2018, the mix-limited regime has become the dominant O-3 formation regime for 55% of the YRD cities. Consequently, the decreases of both NOx (3.3% yr(-1)) and VOCs (7.7% yr(-1)) in 2018-2020 obviously slowed down the aggravating trend of O-3. Our study argues that with the implementation of coordinated regional reduction of NOx and VOCs, an effective O-3 control is emerging in the YRD region.Peer reviewe

Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array

Gallbladder disease (GBD) has an overall prevalence of 10-40% depending on factors such as age, gender, population, obesity and diabetes, and represents a major economic burden. Although gallstones are composed of cholesterol by-products and are associated with obesity, presumed causal pathways remain unproven, although BMI reduction is typically recommended. We performed genetic studies to discover candidate genes and define pathways involved in GBD. We genotyped 15,241 women of European ancestry from three cohorts, including 3216 with GBD, using the Human cardiovascular disease (HumanCVD) BeadChip containing up to ~ 53,000 single-nucleotide polymorphisms (SNPs). Effect sizes with P-values for development of GBD were generated. We identify two new loci associated with GBD, GCKR rs1260326:T>C (P = 5.88 × 10(-7), ß = -0.146) and TTC39B rs686030:C>A (P = 6.95 x 10(-7), ß = 0.271) and detect four independent SNP effects in ABCG8 rs4953023:G>A (P=7.41 × 10(-47), ß = 0.734), ABCG8 rs4299376:G(>)T (P = 2.40 × 10(-18), ß = 0.278), ABCG5 rs6544718:T>C (P = 2.08 × 10(-14), ß = 0.044) and ABCG5 rs6720173:G>C (P = 3.81 × 10(-12), ß(=)0.262) in conditional analyses taking genotypes of rs4953023:G>A as a covariate. We also delineate the risk effects among many genotypes known to influence lipids. These data, from the largest GBD genetic study to date, show that specific, mainly hepatocyte-centred, components of lipid metabolism are important to GBD risk in women. We discuss the potential pharmaceutical implications of our findings

Influence of Environmentally Specific Transformational Leadership on Employees’ Green Innovation Behavior—A Moderated Mediation Model

Ecological environment issues put forward higher requirements for enterprises to undertake environmental responsibility. Therefore, how to encourage employees’ green innovation behavior (EGIB) is of great significance for enterprises to practice green development. Based on the social exchange theory, this study constructs a moderating mediation model to explain the influence of environmentally specific transformational leadership (ESTL) on EGIB, in which green organization identity (GOI) and environmental commitment (EC) are used as mediators and the supervisor’s organizational embodiment (SOE) is used as a moderator. Data collected from 297 employees of the manufacturing industry in China are used for empirical analysis. Results show that (a) ESTL positively affects EGIB, (b) both GOI and EC mediate the positive relationship between ESTL and EGIB, (c) the path of GOI—EC mediates the positive relationship between ESTL and EGIB, and (d) SOE positively moderates the indirect effect of ESTL on EGIB through GOI and EC, and SOE moderates the indirect effect of ESTL on EGIB through the path of GOI—EC. Theoretical contributions, practical implications, and future research are also discussed

Optimization of magnetic coupling mechanism of dynamic wireless power transfer based on NSGA-II algorithm

Abstract Optimization of magnetic coupling mechanism is an important way to improve the performance of a dynamic wireless power transfer system. Inspired by the common radial magnetic core for circular coils, a new radial magnetic core for rectangular coils is adopt. Through simulation and experimental results comparison, which has higher coupling coefficient with the same core area. Combined with the magnetic circuit analysis, the magnetic flux leakage and conduction regions are divided into magnetic fluxes with different shapes, which magnetic resistances are calculated respectively. Based on the simulation results, parameter distributions of fluxes under different conditions are obtained. Therefore, the expressions of the coupling coefficient k of the adopt magnetic cores and coils and the design parameters of coils and cores are obtained. Taking the maximum k and the minimum rate of change of coupling coefficient with 100 mm displacement as the optimization objectives, a multi-objective optimization solution is carried out by using NSGA-II algorithm. The coil optimization scheme is obtained and verified by experiments. k and Δk are 0.442 and 6.8% respectively, and the errors are less than 5%. In the optimization process, there is no simulation model constructed. The optimization modeling combined of magnetic field segmentation method and parameter fitting has lower complexity and calculation time of optimization

The Finite Element Analysis for a Mini-Conductance Probe in Horizontal Oil-Water Two-Phase Flow

Oil-water two-phase flow is widespread in petroleum industry processes. The study of oil-water two-phase flow in horizontal pipes and the liquid holdup measurement of oil-water two-phase flow are of great importance for the optimization of the oil production process. This paper presents a novel sensor, i.e., a mini-conductance probe (MCP) for measuring pure-water phase conductivity of oil-water segregated flow in horizontal pipes. The MCP solves the difficult problem of obtaining the pure-water correction for water holdup measurements by using a ring-shaped conductivity water-cut meter (RSCWCM). Firstly, using the finite element method (FEM), the spatial sensitivity field of the MCP is investigated and the optimized MCP geometry structure is determined in terms of the characteristic parameters. Then, the responses of the MCP for the oil-water segregated flow are calculated, and it is found that the MCP has better stability and sensitivity to the variation of water-layer thickness in the condition of high water holdup and low flow velocity. Finally, the static experiments for the oil-water segregated flow were carried out and a novel calibration method for pure-water phase conductivity measurements was presented. The validity of the pure-water phase conductivity measurement with segregated flow in horizontal pipes was verified by experimental results

Temporal Analysis Reveals the Transient Differential Expression of Transcription Factors That Underlie the Trans-Differentiation of Human Monocytes to Macrophages

The activation of monocytes and their trans-differentiation into macrophages are critical processes of the immune response. Prior work has characterized the differences in the expression between monocytes and macrophages, but the transitional process between these cells is poorly detailed. Here, we analyzed the temporal changes of the transcriptome during trans-differentiation of primary human monocytes into M0 macrophages. We find changes with many transcription factors throughout the process, the vast majority of which exhibit a maximally different expression at the intermediate stages. A few factors, including AP-1, were previously known to play a role in immunological transitions, but most were not. Thus, these findings indicate that this trans-differentiation requires the dynamic expression of many transcription factors not previously discussed in immunology, and provide a foundation for the delineation of the molecular mechanisms associated with healthy or pathological responses that involve this transition

Detection of Selection Signatures in Chinese Landrace and Yorkshire Pigs Based on Genotyping-by-Sequencing Data

The domestic pigs have been undergone intense selection pressures for these development of interested traits following domestication and modern breeding. This has altered many traits in most of pig breeds, such as growth rate, body weight, fertility, and immunity. Thus, the objectives of this study were to (1) detect these selection signatures and identify the candidate genes that show evidences of recent artificial selection at the level of whole genome, (2) be beneficial to understand the relationship between genomic structure and phenotypic diversity, and (3) highlight the key roles of these candidate genes in growth and development in the two breeds. The data consisted of total raw number of 345570 single nucleotide polymorphisms (SNPs) in 1200 individuals from the Chinese Landrace pigs (L, n = 600) and Yorkshire pigs (Y, n = 600). Based on these SNPs data, two complementary methods, population differentiation (Fst) and composite likelihood ratio test (CLR), were carried out to detect the selection signatures in this study. A total of 540 potential selection regions (50 kb) which contained 111 candidate genes were detected for Landrace-Yorkshire pair (L-Y) by Fst. In addition, 73 and 125 candidate genes were found for Landrace pigs and Yorkshire pigs by CLR test based on 321 and 628 potential selection regions, respectively. Some candidate genes are associated with important traits and signaling pathways including the ACACA, MECR, COL11A1, GHR, IGF1R, IGF2R, IFNG, and MTOR gene. The ACACA and MECR gene are related to fatty acid biosynthesis. The COL11A1 gene is essential for the development of the normal differentiation. The GHR, IGF1R, and IGF2R gene are significant candidate genes which play major roles in the growth and development in animals. The IFNG gene is associated with some aspects of immune response. The MTOR gene regulates many signaling pathways and signaling transduction pathway

Differential DNA methylation analysis reveals key genes in Chinese Qingyu and Landrace pigs

The Chinese Qingyu pig is a typical domestic fatty pig breed and an invaluable indigenous genetic resource in China. Compared with Landrace pig, Qingyu pig has unique meat characteristics, including muscle development, intramuscular fat, and other meat quality traits. At present, few studies have explored the epigenetic difference due to DNA methylation between Qingyu pig and Landrace pig. In this study, 30 Qingyu pigs and 31 Landrace pig were subjected to reduced representation bisulfite sequencing (RRBS). A genome wide differential DNA methylation analysis was conducted. Six genomic regions, including regions on sus scrofa chromosome (SSC) 1: 266.09-274.23Mb, SSC5:0.88-10.68Mb, SSC8:41.23-48.51Mb, SSC12:45.43-54.38Mb, SSC13:202.15-207.95Mb, and SSC14:126.43-139.85Mb, were regarded as key regions that may be associated with phenotypic differences between Qingyu pig and Landrace pig. Furthermore, according to the further analysis, 5 differential methylated genes (ADCY1, FUBP3, GRIN2B, KIT, and PIK3R6) were deemed as key candidate genes that might be associated with meat characteristics. Our findings provide new insights into the difference of DNA methylation between Qingyu pig and Landrace pig. The results enrich the epigenetic research of Chinese Qingyu pigs.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

Optimization of Critical Factors Affecting Dynamic Membrane Formation in a Gravity-Driven Self-Forming Dynamic Membrane Bioreactor towards Low-Cost and Low-Maintenance Wastewater Treatment

Self-forming dynamic membrane (SFDM) formation is affected by a variety of operating conditions. However, previous studies have only focused on individual influencing factors and a systematic analysis of important factors is lacking. In this study, an aerobic self-forming dynamic membrane bioreactor (SFDMBR) was developed for the treatment of domestic wastewater with the critical factors that affect the effective formation of SFDM optimized, and the operational performances under optimized formation conditions confirmed. The results indicated that SFDM could be formed within 5 min using 48 μm stainless-steel mesh as the supporting material at a sludge concentration of 5–6 g/L and a gravity waterhead of 15 cm. And the SFDM formed could maintain a stable flux of 30–50 LMH, and the removals of COD, SCOD, and NH4+-N were 93.28%, 82.85%, and 95.46%, respectively. Furthermore, the cake layer resistance (reversible fouling) contributed to 95.93% of the total filtration resistance, thus a simple physical cleaning can effectively restore the flux indicating a low-maintenance requirement. This study provides valuable insights into the optimization and application of the SFDMBR process