Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease

Alzheimer disease (AD) is an age-related neurodegenerative disorder characterized by the presence of senile plaques, neurofibrillary tangles and neuronal loss. Amyloid-β protein (Aβ) deposition plays a critical role in the development of AD. It is now generally accepted that massive neuronal death due to apoptosis is a common characteristic in the brains of patients suffering from neurodegenerative diseases, and apoptotic cell death has been found in neurons and glial cells in AD. Melatonin is a secretory product of the pineal gland; melatonin is a potent antioxidant and free radical scavenger and may play an important role in aging and AD. Melatonin decreases during aging and patients with AD have a more profound reduction of this indoleamine. Additionally, the antioxidant properties, the anti-amyloidogenic properties and anti-apoptotic properties of melatonin in AD models have been studied. In this article, we review the anti-amyloidogenic and anti-apoptotic role of melatonin in A

Design Sensitivity Analysis and Optimization of High Frequency Radiation Problems Using Energy Finite Element Method and Energy Boundary Element Method

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77146/1/AIAA-2004-4615-338.pd

Competition or cooperation? Research on the spatial game relationship of regional carbon emission efficiency

The gradient differences of economic development and industrial structure differences in Jing-Jin-Ji Region are significant. The ability of Jing-Jin-Ji Region to pay for environmental protection is imbalanced. The above two situations make it difficult to achieve coordinated pollution reduction and carbon reduction governance. Accurately measuring carbon emission efficiency and thoroughly analyzing the cooperation and competition relationship of regional carbon emission reduction based on fully considering stakeholders are of great significance for the joint construction, prevention and control of regional ecological environment. The research is also of great significance for promoting high-quality economic development and ensuring effective protection of the regional ecological environment. This study combines game theory and DEA theory to measure the carbon emission efficiency of the Jing-Jin-Ji Region, and then uses spatial game theory to analyze the average degree of being attacked, anti-attack ability, strongest attacker, and optimal partner for the carbon emission efficiency of different DMUs. The study concluded that: 1) Xicheng District and Hedong District have higher carbon emission efficiency, while Mentougou District, Fengtai District, Changping District, Fangshan District, Shijingshan District, Pinggu District and Yanqing County have the lowest carbon emission efficiency. 2) From an analysis of the degree of being attacked, it can be observed that economically developed areas experience a higher average degree of being attacked compared to economically underdeveloped areas. In regions with lower economic development, the influence of the local government on reducing carbon emissions is not significant, whether acting independently or in collaboration. Regions with contrasting industrial structures could be ideal partners, and areas with higher carbon emission efficiency could collaborate with regions with lower carbon emission efficiency to achieve greater reduction potential

Green synthesis and antibacterial/fungal studies of two new Schiff base derived from 4-(imidazol-1-yl)benzaldehyde

298-304This study synthesizes two new Schiff bases, (E)-1-(4-1H-imidazol-1-yl)phenyl)-N-(o-tolyl)methanimine and (E)-1-(4-(1Himidazol- 1-yl)phenyl)-N-(m-tolyl)methanimine through condensation reaction between 4-(imidazol-1-yl)benzaldehyde and 2-toluidine/o-toluidine, respectively. FT-IR, X-ray diffraction and 1H NMR spectroscopy have been carried out to characterize the structure of the products. Through antibacterial/ antifungal activity tests performed using 8 kinds of bacteria/fungus, it is found that the both of the two Schiff bases can suppress the growth of Staphylococcus, Bacillus subtilis and Salmonella, showing good potential as antibacterial drug

The Role of Multiple Re-Entry Tears in Type B Aortic Dissection Progression: A Longitudinal Study Using a Controlled Swine Model

False lumen (FL) expansion often occurs in type B aortic dissection (TBAD) and has been associated with the presence of re-entry tears. This longitudinal study aims to elucidate the role of re-entry tears in the progression of TBAD using a controlled swine model, by assessing aortic hemodynamics through combined imaging and computational modeling

Unraveling the diversity of sedimentary sulfate-reducing prokaryotes (SRP) across Tibetan saline lakes using epicPCR

Sulfate reduction is an important biogeochemical process in the ecosphere; however, the major taxa of sulfate reducers have not been fully identified. Here, we used epicPCR (Emulsion, Paired Isolation, and Concatenation PCR) technology to identify the phylogeny of sulfate-reducing prokaryotes (SRP) in sediments from Tibetan Plateau saline lakes. A total of 12,519 OTUs and 883 SRP-OTUs were detected in ten lakes by sequencing of 16S rRNA gene PCR amplicons and epicPCR products of fused 16S rRNA plus dsrB gene, respectively, with Proteobacteria, Firmicutes, and Bacteroidetes being the dominant phyla in both datasets. The 120 highly abundant SRP-OTUs (>1% in at least one sample) were affiliated with 17 described phyla, only 7 of which are widely recognized as SRP phyla. The majority of OTUs from both the whole microbial communities and the SRPs were not detected in more than one specific lake, suggesting high levels of endemism. The -diversity of the entire microbial community and SRP sub-community showed significant positive correlations. The pH value and mean water temperature of the month prior to sampling were the environmental determinants for the whole microbial community, while the mean water temperature and total nitrogen were the major environmental drivers for the SRP sub-community. This study revealed there are still many undocumented SRP in Tibetan saline lakes, many of which could be endemic and adapted to specific environmental conditions.Peer reviewe