Investment guidance for the Chinese medical device market

The medical device market is one of the most attractive and profitable areas in the global economy. Since China opened its doors to the world it has attracted increasing amounts of foreign investment. The Chinese medical device market is currently one of the most promising and fastest growing markets, which is the second largest market in the world with 200 billion yuan (RMB) total sales in 2013. This paper illustrates the geographical distribution of the Chinese medical device industry, combined with the location quotient (LQ) assessment, to reveal the medical device industry’s professional level and degree of concentration in each province, providing guidance for investors who are interested in medical device investment in China. The LQ and market share (MS) matrix reveals that the best investment regions in China are: Bohai Economic Rim, Yangtze River Delta and Pearl River Delta Economic Zones

On the stability of a laminated beam with structural damping and Gurt–Pipkin thermal law

In this paper, we investigate the stabilization of a one-dimensional thermoelastic laminated beam with structural damping coupled with a heat equation modeling an expectedly dissipative effect through heat conduction governed by Gurtin–Pipkin thermal law. Under some assumptions on the relaxation function g, we establish the well-posedness of the problem by using Lumer–Phillips theorem. Furthermore, we prove the exponential stability and lack of exponential stability depending on a stability number by using the perturbed energy method and Gearhart–Herbst–Prüss–Huang theorem, respectively

On (d,1)-total numbers of graphs

AbstractA (d,1)-total labelling of a graph G assigns integers to the vertices and edges of G such that adjacent vertices receive distinct labels, adjacent edges receive distinct labels, and a vertex and its incident edges receive labels that differ in absolute value by at least d. The span of a (d,1)-total labelling is the maximum difference between two labels. The (d,1)-total number, denoted λdT(G), is defined to be the least span among all (d,1)-total labellings of G. We prove new upper bounds for λdT(G), compute some λdT(Km,n) for complete bipartite graphs Km,n, and completely determine all λdT(Km,n) for d=1,2,3. We also propose a conjecture on an upper bound for λdT(G) in terms of the chromatic number and the chromatic index of G

Optimal Design of Bacterial Carpets for Fluid Pumping

In this work, we outline a methodology for determining optimal helical flagella placement and phase shift that maximize fluid pumping through a rectangular flow meter above a simulated bacterial carpet. This method uses a Genetic Algorithm (GA) combined with a gradient-based method, the Broyden-Fletcher-Goldfarb-Shanno (BFGS) algorithm, to solve the optimization problem and the Method of Regularized Stokeslets (MRS) to simulate the fluid flow. This method is able to produce placements and phase shifts for small carpets and could be adapted for implementation in larger carpets and various fluid tasks. Our results show that given identical helices, optimal pumping configurations are influenced by the size of the flow meter. We also show that intuitive designs, such as uniform placement, do not always lead to a high-performance carpet

Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats

Background: Continuous damage from oxidative stress and apoptosis are the important mechanisms that facilitate chronic heart failure (CHF). Molecular hydrogen (H2) has potentiality in the aspects of anti-oxidation. The objectives of this study were to investigate the possible mechanism of H2 inhalation in delaying the progress of CHF.Methods and Results: A total of 60 Sprague-Dawley (SD) rats were randomly divided into four groups: Sham, Sham treated with H2, CHF and CHF treated with H2. Rats from CHF and CHF treated with H2 groups were injected isoprenaline subcutaneously to establish the rat CHF model. One month later, the rat with CHF was identified by the echocardiography. After inhalation of H2, cardiac function was improved vs. CHF (p < 0.05), whereas oxidative stress damage and apoptosis were significantly attenuated (p < 0.05). In this study, the mild oxidative stress was induced in primary cardiomyocytes of rats, and H2 treatments significantly reduced oxidative stress damage and apoptosis in cardiomyocytes (p < 0.05 or p < 0.01). Finally, as a pivotal transcription factor in reactive oxygen species (ROS)-apoptosis signaling pathway, the expression and phosphorylation of p53 were significantly reduced by H2 treatment in this rat model and H9c2 cells (p < 0.05 or p < 0.01).Conclusion: As a safe antioxidant, molecular hydrogen mitigates the progression of CHF via inhibiting apoptosis modulated by p53. Therefore, from the translational point of view and speculation, H2 is equipped with potential therapeutic application as a novel antioxidant in protecting CHF in the future

Clinicopathological Significance and Prognostic Value of DNA Methyltransferase 1, 3a, and 3b Expressions in Sporadic Epithelial Ovarian Cancer

Altered DNA methylation of tumor suppressor gene promoters plays a role in human carcinogenesis and DNA methyltransferases (DNMTs) are responsible for it. This study aimed to determine aberrant expression of DNMT1, DNMT3a, and DNMT3b in benign and malignant ovarian tumor tissues for their association with clinicopathological significance and prognostic value. A total of 142 ovarian cancers and 44 benign ovarian tumors were recruited for immunohistochemical analysis of their expression. The data showed that expression of DNMT1, DNMT3a, and DNMT3b was observed in 76 (53.5%), 92 (64.8%) and 79 (55.6%) of 142 cases of ovarian cancer tissues, respectively. Of the serious tumors, DNMT3a protein expression was significantly higher than that in benign tumor samples (P = 0.001); DNMT3b was marginally significant down regulated in ovarian cancers compared to that of the benign tumors (P = 0.054); DNMT1 expression has no statistical difference between ovarian cancers and benign tumor tissues (P = 0.837). Of the mucious tumors, the expression of DNMT3a, DNMT3b, and DNMT1 was not different between malignant and benign tumors. Moreover, DNMT1 expression was associated with DNMT3b expression (P = 0.020, r = 0.195). DNMT1 expression was associated with age of the patients, menopause status, and tumor localization, while DNMT3a expression was associated with histological types and serum CA125 levels and DNMT3b expression was associated with lymph node metastasis. In addition, patients with DNMT1 or DNMT3b expression had a trend of better survival than those with negative expression. Co-expression of DNMT1 and DNMT3b was significantly associated with better overall survival (P = 0.014). The data from this study provided the first evidence for differential expression of DNMTs proteins in ovarian cancer tissues and their associations with clinicopathological and survival data in sporadic ovarian cancer patients