1,414 research outputs found
Effects of in-chain and off-chain substitutions on spin fluctuations in the spin-Peierls compound CuGeO_3
The effect of in-chain and off-chain substitutions on 1D spin fluctuations in
the spin-Peierls compound CuGeO_3 has been studied using Raman scattering in
order to understand the interplay between defect induced states, enhanced
spin-spin correlations and the ground state of low dimensional systems.
In-chain and off-chain substitutions quench the spin-Peierls state and induce
3D antiferromagnetic order at T\leq 5 K. Consequently a suppression of a 1D
gap-induced mode as well as a constant intensity of a spinon continuum are
observed at low temperatures. A 3D two-magnon density of states now gradually
extends to higher temperatures T\leq 60K compared with pure CuGeO_3. This
effect is more pronounced in the case of off-chain substitutions (Si) for which
a N\'eel state occurs over a larger substitution range, starting at very low
concentrations. Besides, additional low energy excitations are induced. These
effects, i.e. the shift of a dimensional crossover to higher temperatures are
due to an enhancement of the spin-spin correlations induced by a small amount
of substitutions. The results are compared with recent Monte Carlo studies on
substituted spin ladders, pointing to a similar instability of coupled,
dimerized spin chains and spin ladders upon substitution.Comment: 14 pages, 6 eps figures, to be published in PR
Infrared study of spin-Peierls compound alpha'-NaV2O5
Infrared reflectance of alpha'-NaV2O5 single crystals in the frequency range
from 50 cm-1 to 10000 cm-1 was studied for a, b and c-polarisations. In
addition to phonon modes identification, for the a-polarised spectrum a broad
continuum absorption in the range of 1D magnetic excitation energies was found.
The strong near-IR absorption band at 0.8 eV shows a strong anisotropy with
vanishing intensity in c-polarisation. Activation of new phonons due to the
lattice dimerisation were detected below 35K as well as pretransitional
structural fluctuations up to 65K.Comment: 3 pages, 2 figures, 1 table. Contributed paper for the SCES'98 (15-18
July 1998, Paris). To be published in Physica
Effectiveness of lurasidone in schizophrenia or schizoaffective patients switched from other antipsychotics: a 6-month, open-label, extension study
Objective. To evaluate the long-term safety and tolerability of lurasidone in schizophrenia and schizoaffective disorder patients switched to lurasidone. Method. Patients in this multicenter, 6-month open-label, flexible-dose, extension study had completed a core 6-week randomized trial in which clinically stable, but symptomatic, outpatients with schizophrenia or schizoaffective disorder were switched to lurasidone. Patients started the extension study on treatment with the same dose of lurasidone taken at study endpoint of the 6-week core study; following this, lurasidone was flexibly dosed (40-120 mg/day), if clinically indicated, starting on Day 7 of the extension study. The primary safety endpoints were the proportion of patients with treatment emergent adverse events (AEs), serious AEs, or who discontinued due to AEs. Secondary endpoints included metabolic variables and measures of extrapyramidal symptoms and akathisia, as well as the Positive and Negative Syndrome Scale (PANSS), Clinical Global Impressions-Severity (CGI-S), and the Calgary Depression Scale for Schizophrenia (CDSS). The study was conducted from August 2010 to November 2011. Results. Of the 198 patients who completed the 6-week core study, 149 (75.3%) entered the extension study and 148 received study medication. A total of 98 patients (65.8%) completed the 6-month extension study. Lurasidone 40, 80, and 120 mg were the modal daily doses for 19 (12.8%), 65 (43.9%), and 64 (43.2%) of patients, respectively. Overall mean (SD) daily lurasidone dose was 102.0 mg (77.1). The most commonly reported AEs were insomnia (13 patients [8.8%]), nausea (13 patients [8.8%]), akathisia (12 patients [8.1%]), and anxiety (9 patients [6.1%]). A total of 16 patients (10.8%) had at least one AE leading to discontinuation from the study. Consistent with prior studies of lurasidone, there was no signal for clinically relevant adverse changes in body weight, lipids, glucose, insulin, or prolactin. Movement disorder rating scales did not demonstrate meaningful changes. Treatment failure (defined as any occurrence of discontinuation due to insufficient clinical response, exacerbation of underlying disease, or AE) was observed for 19 patients (12.8% of patients entering) and median time to treatment failure was 58 days (95% CI 22-86). The discontinuation rate due to any cause was 50/148 (33.8%), and median time to discontinuation was 62 days (95% CI 30-75). The mean PANSS total score, mean CGI-S score, and mean CDSS score decreased consistently from core study baseline across extension visits, indicating an improvement in overall condition. Conclusions. In this 6-month, open-label extension study, treatment with lurasidone was generally well-tolerated with sustained improvement in efficacy measures observed in outpatients with schizophrenia or schizoaffective disorder who had switched to lurasidone from a broad range of antipsychotic agents
Social and functional outcomes with two doses of aripiprazole lauroxil vs placebo in patients with schizophrenia: a post-hoc analysis of a 12-week phase 3 efficacy study
NaV_2O_5 as a quarter-filled ladder compound
A new X-ray diffraction study of the one-dimensional spin-Peierls compound
\alpha-NaV_2O_5 reveals a centrosymmetric (Pmmn) crystal structure with one
type of V site, contrary to the previously postulated non-centrosymmetric
P2_1mn structure with two types of V sites (V^{+4} and V^{+5}). Density
functional calculations indicate that NaV_2O_5 is a quarter-filled ladder
compound with the spins carried by V-O-V molecular orbitals on the rungs of the
ladder. Estimates of the charge-transfer gap and the exchange coupling agree
well with experiment and explain the insulating behavior of NaV_2O_5 and its
magnetic properties.Comment: Final version for PRL, value of U correcte
Magnetic bound states in the quarter-filled ladder system }
Raman scattering in the quarter-filled spin ladder system alpha'-NaV_2O_5
shows in the dimerized singlet ground state () an unexpected
sequence of three magnetic bound states. Our results suggest that the recently
proposed mapping onto an effective spin chain for has to be given
up in favor of the full topology and exchange paths of a ladder in the
dimerized phase for . As the new ground state we propose a dynamic
superposition of energetically nearly degenerate dimer configurations on the
ladder.Comment: 5 pages, 4 figures, to be published in PRB, brief reports, Dec. 199
Coexistence of charge density wave and spin-Peierls orders in quarter-filled quasi-one dimensional correlated electron systems
Charge and spin-Peierls instabilities in quarter-filled (n=1/2) compounds
consisting of coupled ladders and/or zig-zag chains are investigated. Hubbard
and t-J models including local Holstein and/or Peierls couplings to the lattice
are studied by numerical techniques. Next nearest neighbor hopping and magnetic
exchange, and short-range Coulomb interactions are also considered. We show
that, generically, these systems undergo instabilities towards the formation of
Charge Density Waves, Bond Order Waves and (generalized) spin-Peierls modulated
structures. Moderate electron-electron and electron-lattice couplings can lead
to a coexistence of these three types of orders. In the ladder, a zig-zag
pattern is stabilized by the Holstein coupling and the nearest-neighbor Coulomb
repulsion. In the case of an isolated chain, bond-centered and site-centered
2k_F and 4k_F modulations are induced by the local Holstein coupling. In
addition, we show that, in contrast to the ladders, a small charge ordering in
the chains, strongly enhances the spin-Peierls instability. Our results are
applied to the NaV_2O_5 compound (trellis lattice) and various phases with
coexisting charge disproportionation and spin-Peierls order are proposed and
discussed in the context of recent experiments. The role of the long-range
Coulomb potential is also outlined.Comment: 10 pages, Revtex, 10 encapsulated figure
Temperature dependence of optical spectral weights in quarter-filled ladder systems
The temperature dependence of the integrated optical conductivity I(T)
reflects the changes of the kinetic energy as spin and charge correlations
develop. It provides a unique way to explore experimentally the kinetic
properties of strongly correlated systems. We calculated I(T) in the frame of a
t-J-V model at quarter-filling for ladder systems, like NaV_2O_5, and show that
the measured strong T dependence of I(T) for NaV_2O_5 can be explained by the
destruction of short range antiferromagnetic correlations. Thus I(T) provides
detailed information about super-exchange and magnetic energy scales.Comment: 4 pages, 5 figure
Charge Order Driven spin-Peierls Transition in NaV2O5
We conclude from 23Na and 51V NMR measurements in NaxV2O5(x=0.996) a charge
ordering transition starting at T=37 K and preceding the lattice distortion and
the formation of a spin gap Delta=106 K at Tc=34.7 K. Above Tc, only a single
Na site is observed in agreement with the Pmmn space group of this first
1/4-filled ladder system. Below Tc=34.7 K, this line evolves into eight
distinct 23Na quadrupolar split lines, which evidences a lattice distortion
with, at least, a doubling of the unit cell in the (a,b) plane. A model for
this unique transition implying both charge density wave and spin-Peierls order
is discussed.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let
Spin gap behavior and charge ordering in \alpha^{\prime}-NaV_2O_5 probed by light scattering
We present a detailed analysis of light scattering experiments performed on
the quarter-filled spin ladder compound -NaVO for
the temperature range 5 KT300 K. This system undergoes a phase
transition into a singlet ground state at T=34 K accompanied by the formation
of a super structure. For T34 K several new modes were detected. Three of
these modes are identified as magnetic bound states. Experimental evidence for
charge ordering on the V sites is detected as an anomalous shift and splitting
of a V-O vibration at 422 cm for temperatures above 34 K. The smooth and
crossover-like onset of this ordering at T= 80 K is accompanied by
pretransitional fluctuations both in magnetic and phononic Raman scattering. It
resembles the effect of stripe order on the super structure intensities in
LaNiO.Comment: 36 pages, 11 figures, accepted for publication in PRB (sept.99
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