176 research outputs found
Further accelerating cell Line development and CMC timeline: The journey from COVID to non-COVID programs
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Investigation of Electron-Phonon Coupling in Epitaxial Silicene by In-situ Raman Spectroscopy
In this letter, we report that the special coupling between Dirac fermion and
lattice vibrations, in other words, electron-phonon coupling (EPC), in silicene
layers on Ag(111) surface was probed by an in-situ Raman spectroscopy. We find
the EPC is significantly modulated due to tensile strain, which results from
the lattice mismatch between silicene and the substrate, and the charge doping
from the substrate. The special phonon modes corresponding to two-dimensional
electron gas scattering at edge sites in the silicene were identified.
Detecting relationship between EPC and Dirac fermion through the Raman
scattering will provide a direct route to investigate the exotic property in
buckled two-dimensional honeycomb materials.Comment: 15 pages, 4 figure
Ultra-intensified intermittent-perfusion fed-batch (UIIPFB) process quadrupled productivity of a bispecific antibody
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Promoted Photocharge Separation in 2D Lateral Epitaxial Heterostructure for Visible‐Light‐Driven CO2 Photoreduction
Photocarrier recombination remains a big barrier for the improvement of solar energy conversion efficiency. For 2D materials, construction of heterostructures represents an efficient strategy to promote photoexcited carrier separation via an internal electric field at the heterointerface. However, due to the difficulty in seeking two components with suitable crystal lattice mismatch, most of the current 2D heterostructures are vertical heterostructures and the exploration of 2D lateral heterostructures is scarce and limited. Here, lateral epitaxial heterostructures of BiOCl @ Bi2O3 at the atomic level are fabricated via sonicating‐assisted etching of Cl in BiOCl. This unique lateral heterostructure expedites photoexcited charge separation and transportation through the internal electric field induced by chemical bonding at the lateral interface. As a result, the lateral BiOCl @ Bi2O3 heterostructure demonstrates superior CO2 photoreduction properties with a CO yield rate of about 30 µmol g−1 h−1 under visible light illumination. The strategy to fabricate lateral epitaxial heterostructures in this work is expected to provide inspiration for preparing other 2D lateral heterostructures used in optoelectronic devices, energy conversion, and storage fields
Towards Layer-Selective Quantum Spin Hall Channels in Weak Topological Insulator Bi4Br2I2
Weak topological insulators, constructed by stacking quantum spin Hall
insulators with weak interlayer coupling, offer promising quantum electronic
applications through topologically nontrivial edge channels. However, the
currently available weak topological insulators are stacks of the same quantum
spin Hall layer with translational symmetry in the out-of-plane direction,
leading to the absence of the channel degree of freedom for edge states. Here,
we study a candidate weak topological insulator, Bi4Br2I2, which is alternately
stacked by three different quantum spin Hall insulators, each with tunable
topologically non-trivial edge states. Our angle-resolved photoemission
spectroscopy and first-principles calculations show that an energy gap opens at
the crossing points of different Dirac cones correlated with different layers
due to the interlayer interaction. This is essential to achieve the tunability
of topological edge states as controlled by varying the chemical potential. Our
work offers a perspective for the construction of tunable quantized conductance
devices for future spintronic applications
Improving EFL Learners Language Written Production Using Subtitled Videos
English as a Foreign Language (EFL) Learners tend to produce their speech or written production as they are associated with what they see and what they hear. So, they are able and desired to give comment spontaneously after watching and listening to them. Producing written language can, as a matter of fact, be detected from learners\u27 fluency, accuracy and complexity. This article endeavors to elaborate written language production done by university students by using English subtitled videos. Two intact groups were assigned to accomplish two different tasks; that is, one group watched the video with subtitle and the other one without subtitle. The result of the study reveals that learners who carry out the tasks of watching video with subtitle improve their ability in written production in terms of fluency and accuracy regardless to complexity
Vasculogenic mimicry score identifies the prognosis and immune landscape of lung adenocarcinoma
Background: Lung cancer has a high incidence and mortality rate worldwide. Vasculogenic mimicry (VM) is a specific modality of tumor angiogenesis that could potentially be a new target for tumor therapy. The purpose of this study was to explore the role of VM-related genes in assessing the prognosis and immune landscape of lung cancer.Methods: VM-related genes were obtained from previous studies, and the expression data and clinical data of lung adenocarcinoma (LUAD) patients were obtained from the TCGA database and GEO database. We performed enrichment analysis of 24 VM-related genes and screened hub genes by constructing a protein–protein interaction network and using Cytoscape software. Subsequently, we developed the VM score based on univariate Cox regression analysis and Lasso analysis and validated the VM score on the GSE72094 dataset. In addition, we constructed a nomogram based on the VM score in the TCGA cohort. Finally, we explored the correlation between the VM score and the tumor microenvironment, immune cell infiltration, immune checkpoints, and drug sensitivity.Results: Enrichment analysis revealed that VM-related genes were associated with the HIF signaling pathway and angiogenic pathway. We developed a VM score based on 3 genes (EPHA2, LAMC2 and LOXL2) in LUAD patients. Kaplan-Meier analysis showed that the VM score was associated with poor prognosis in LUAD patients. The receiver operating characteristic curve suggested that the VM score and nomogram are valid predictors for the overall survival of LUAD patients. The VM score was significantly correlated with immune cell infiltration, such as naïve B cells, neutrophils, and eosinophils, and there was a difference in the TME between the high VM score group and the low VM score group. LUAD patients in the high VM score group were more sensitive to antitumor drugs.Conclusion: In summary, the VM score developed in this study is a valuable indicator for evaluating the prognosis and immune landscape of LUAD patients. VM may be a potential target for antitumor therapy in lung cancer
High-Entropy Enhanced Negative Thermal Expansion Perfomance in Antiperovkites
The negative thermal expansion (NTE) materials, which can act as
thermal-expansion compensators to counteract the positive thermal expansion,
have great applications merit in precision engineering. However, the
exploration of NTE behavior with a wide temperature range has reached its upper
ceiling through traditional doping strategies due to composition limitations.
The unique sluggish characteristic in phase transition and extended
optimization space in recent high entropy systems has great potential to
broaden the temperature range in electronic transitions-induced NTE materials.
Mn-based anti-perovskites offer an ideal platform for the exploration of high
entropy NTE material due to their abundant element selection and controllable
NTE performance. In this paper, the high entropy strategy is first introduced
to broaden the NTE temperature range by relaxing the abrupt phase transition in
Mn-based anti-perovskite nitride. We propose an empirical screening method to
synthesize the high-entropy anti-perovskite (HEAP). it is found that magnetic
phase separation from anti-ferromagnetic CII to paramagnetic CI surviving in an
ultra-wide temperature range of 5K<=T<=350K (Delta_T=345K), revealing a unique
sluggish characteristic. Consequently, a remarkable NTE behavior (up to
Delta_T=235K, 5K<=T<=240K) with a coefficient of thermal expansion of
-4.7x10-6/K, has been obtained in HEAP. It is worth noting that the temperature
range is two/three times wider than that of low-entropy systems. The sluggish
characteristic has been further experimentally proved to come from disturbed
phase transition dynamics due to distortion in atomic spacing and chemical
environmental fluctuation observed by the spherical aberration-corrected
electron microscope. Our demonstration provides a unique paradigm for
broadening the temperature range of NTE materials induced by phase transition
through entropy engineering.Comment: 34 page
Efficient visible-light photocatalysts by constructing dispersive energy band with anisotropic p and s-p hybridization states
Highly efficient visible-light photocatalysts are strongly in demand because they make it possible to achieve higher efficiency in utilization of solar energy, w hich is renewable and abundant. A narrow band gap, effective separation of photoexcited charge carriers, and proper band-edge positions, which depend on the band structure of the photocatalyst, are crucial for solar-energy conversion efficiency. In this review, we have summarized reports on the strategy of exploiting highly efficient visible-light photocatalysts by constructing their band structure with anisotropic p and s-p hybridization states. Taking advantage of their dispersive and easily tunable band properties, enhanced efficiency in solar light absorption, efficient separation of photoexcited charge carriers and catalytic reactions are expected to be simultaneously achieved
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