1,212 research outputs found
Oral peripheral ameloblastoma : a retrospective series study of 25 cases
Peripheral ameloblastoma (PA) is a rare and unusual variant of odontogenic tumor, which was described only in isolated case reports in literature. The objective of this study was to investigate the clinical profile, treatment and outcome of PA in a consecutive case series. A total of 25 patients with histologically confirmed PA from 2001 to 2015 were retrospectively reviewed in our institution. Of the 25 patients, 22 males and 3 females were identified (male: female = 7.3:1). The average age was 48.3 years (range 11-81 years) with lingual or palate gingival region being the most common site (76%). The course of disease was less than 6 months in 92.0% (23/25) of all patients (mean, 3.3 months; range, 1-12 months). All patients underwent complete surgical removal of the lesions, and one lesion recurrence occurred during the follow-up period. The clinical profile and outcome of PA from Eastern China were elucidated in this retrospective analysis based on a case series. Our experience may provide some insights into the differential diagnosis and clinical management of PA. The first choice of treatment is surgical excision, which can result in a good prognosis
Progressive Feature Fusion Network for Enhancing Image Quality Assessment
Image compression has been applied in the fields of image storage and video
broadcasting. However, it's formidably tough to distinguish the subtle quality
differences between those distorted images generated by different algorithms.
In this paper, we propose a new image quality assessment framework to decide
which image is better in an image group. To capture the subtle differences, a
fine-grained network is adopted to acquire multi-scale features. Subsequently,
we design a cross subtract block for separating and gathering the information
within positive and negative image pairs. Enabling image comparison in feature
space. After that, a progressive feature fusion block is designed, which fuses
multi-scale features in a novel progressive way. Hierarchical spatial 2D
features can thus be processed gradually. Experimental results show that
compared with the current mainstream image quality assessment methods, the
proposed network can achieve more accurate image quality assessment and ranks
second in the benchmark of CLIC in the image perceptual model track.Comment: Data Compression Conferenc
Ultrasound Image Segmentation of Thyroid Nodule via Latent Semantic Feature Co-Registration
Segmentation of nodules in thyroid ultrasound imaging plays a crucial role in
the detection and treatment of thyroid cancer. However, owing to the diversity
of scanner vendors and imaging protocols in different hospitals, the automatic
segmentation model, which has already demonstrated expert-level accuracy in the
field of medical image segmentation, finds its accuracy reduced as the result
of its weak generalization performance when being applied in clinically
realistic environments. To address this issue, the present paper proposes ASTN,
a framework for thyroid nodule segmentation achieved through a new type
co-registration network. By extracting latent semantic information from the
atlas and target images and utilizing in-depth features to accomplish the
co-registration of nodules in thyroid ultrasound images, this framework can
ensure the integrity of anatomical structure and reduce the impact on
segmentation as the result of overall differences in image caused by different
devices. In addition, this paper also provides an atlas selection algorithm to
mitigate the difficulty of co-registration. As shown by the evaluation results
collected from the datasets of different devices, thanks to the method we
proposed, the model generalization has been greatly improved while maintaining
a high level of segmentation accuracy
A 2-Styryl-1,8-naphthyridine derivative as a versatile fluorescent probe for the selective recognition of HgÂČâș, Agâș and Fâ» ions by tuning the solvent
A novel fluorescent probe 1 has been synthesized by a microwave reaction, and its ion-binding and fluorescence-sensing properties have been investigated under different solvent conditions. The analysis results indicated that probe 1 can act as a multiple analysis probe by simply tuning the solvent. Probe 1 exhibited high selectively toward HgÂČâș through fluorescence quenching in HâO/DMF. In HâO/1,4-dioxane solution, probe 1 selectively recognized and discriminated between Agâș and HgÂČâș displaying ratiometric behaviour. Moreover, probe 1 readily recognized the anion Fâ» via the ratiometric fluorescent mode in CH3CN. Furthermore, distinct colour changes were observed under UV light, which can be seen by the naked eye and thus used for distinguishing HgÂČâș, Ag+ and Fâ» from the other ions screened herein using probe 1. Interestingly, almost pure white light emission was evident by simply tuning the Fâ» anion-concentration, which makes this system a potential candidate for smart and tunable luminescent materials
Bis(ÎŒ-2-phenylÂquinoline-4-carboxylÂato)bisÂ[aquaÂ(1,10-phenanthroline)(2-phenylÂquinoline-4-carboxylÂato)manganese(II)] dihydrate
In the centrosymmetric dinuclear title complex, [Mn2(C16H10NO2)4(C12H8N2)2(H2O)2]·2H2O, the MnII cation is in a distorted octaÂhedral coordination geometry defined by two N atoms from a 1,10-phenanthroline ligand, one water O atom and three O atoms from three 2-phenylÂquinoline-4-carboxylÂate anions. A pair of 2-phenylÂquinoline-4-carboxylÂate anions bridge two Mn cations, forming the dinuclear molÂecule. An intraÂmoleculr OâHâŻO hydrogen bond occurs. InterÂmolecular OâHâŻO and OâHâŻN hydrogen bonds are present in the crystal structure
Buccal Transmucosal Delivery System of Enalapril for Improved Cardiac Drug Delivery: Preparation and Characterization
Purpose: To prepare and characterize buccal transmucosal delivery system of enalapril maleate for overcoming its low bioavailability, and hence provide improved therapeutic efficacy and patient compliance.Methods: Transmucosal drug delivery systems of enalapril maleate were formulated as buccal films by solvent casting technique using polyvinylpyrrolidone K90, hydroxypropyl methylcellulose, sodium carboxymethylcellulose (high viscosity). The films were evaluated for film weight, thickness, folding endurance, drug content uniformity, surface pH, in vitro residence time, in vitro drug release and ex-vivo permeation.Results: All the formulations showed high drug content (96.45 to 98.49 %). Those with good swelling showed good residence time. In vitro drug release was highest for films prepared with high viscosity grade sodium carboxymethylcellulose (SCMC- HV,F2), releasing 92.24 % of drug in 1.5 h) followed by F4 (containing polyvinyl pyrrolidone K-90 1 % w/v and SCMC (HV) 1 % w/v). Ex-vivo drug permeation at the end of 10 h was 82.24 and 89.9 % for F2 and F4, respectively.Conclusion: Prompt drug release was obtained from the formulation (F2) containing SCMC 2 % w/v with 10 mg enalapril. However, on the basis of the highest swelling and residence time, and controlled drug release, formulation F4 (containing PVP K-90 and SCMC HV) would be suitable for the development of buccal film for effective therapy of cardiac diseases.Keywords: Cardiac disease, Transmucosal, Buccal films, Enalapril maleate, Drug release, Ex-vivo permeatio
Survival Benefit of Neoadjuvant Chemotherapy in Non-small Cell Lung Cancer: An Updated Meta-Analysis of 13 Randomized Control Trials
IntroductionThe survival effectiveness of neoadjuvant chemotherapy in non-small cell lung cancer (NSCLC) is still unclear based on the study of most up-to-date literatures. This article contributes to this problem by conducting an updated meta-analysis.MethodsBased on Burdett et al's (J Thorac Oncol 2006;1:611â621) systematic review, this meta-analysis was conducted. Articles were searched electrically. The possible survival benefit of neoadjuvant chemotherapy was assessed by hazard ratio (HR) in terms of overall survival. A subgroup meta-analysis with only stage III NSCLC was also conducted. The software of Review Manager was used for data management.ResultsThirteen randomized control trials, 6 of which were new ones, were included into this meta-analysis. The overall survival of NSCLC patients in neoadjuvant chemotherapy arm were improved significantly, comparing with those in surgery-alone arm (combined HR = 0.84; 95% confidence interval, 0.77â0.92; p = 0.0001). When only patients with stage III NSCLC were considered, the result was similar (combined HR = 0.84; 95% confidence interval, 0.75â0.95; p = 0.005).ConclusionNeoadjuvant chemotherapy, as an addition of surgery, would significantly improve the overall survival of operable NSCLC patients, including patients with stage III NSCLC
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