El otro: ¿otro más o de más? El papel del intérprete en los procesos comunicativos

Association between household inhalants and nasopharyngeal carcinoma risk, by sex. (DOC 43 kb

Patient characteristics.

<p>Patient characteristics.</p

Univariate hazard ratios from Cox proportional hazards regression models.

<p>Abbreviation: HR, Hazard Ratio; CRT, Concurrent chemoradiotherapy; RT+CT, Radiotherapy+Chemotherapy.</p

Kaplan-Meier plots of the influence of various lifestyle behaviors on survival in NPC patients.

<p>(A) Smoking status; (B) Lifetime cigarette consumption; (C) Alcohol intake; (D) Duration of alcohol intake; (E) Frequency of fruit intake; (F) Body-mass index.</p

Multivariate analyses of clinical variables, demographics and lifestyle behaviors to predict survival.

<p>Note: Each HR is adjusted simultaneously for all the other variables in the table.</p><p>Abbreviation: HR, Hazard Ratio.</p

MOESM1 of Nasopharyngeal brushing: a convenient and feasible sampling method for nucleic acid-based nasopharyngeal carcinoma research

Additional file 1: Table S1. Sequences of Epstein–Barr virus-encoded microRNAs

Area under curves (AUC) as a measure of predictive strength for risk-prediction models based on different indicators^a.

a<p>The environmental model is based on consumption of salted fish and preserved vegetables, and cumulative amount of smoking. The family history of NPC model includes family history of NPC only. The epidemiological model combines both environmental and family history of NPC predictors. The genetic risk score model includes a score derived from seven SNPs identified in the Cantonese GWAS. The inclusive model integrates all data on epidemiological and genetic predictors.</p>b<p>χ² statistic and <i>P</i> value was calculated from the Hosmer–Lemeshow Goodness-of-Fit test, a model with χ² statistic <20 (<i>P</i>>0.01) is considered as a good calibration.</p>c<p>AUC of the models were compared with a nonparametric approach, and <i>P</i> value was obtained from the comparison of the inclusive model with the other models.</p

Reclassification of data for use in epidemiological and inclusive models^a.

a<p>NRI: net reclassification improvement; IDI: integrated discrimination index; Reclassification was calculated for strata of predicted risk of <0.2, 0.2 to 0.3, and ≥0.3.</p

Distribution of risk for NPC by genetic risk score (in quintiles).

<p>Risk of NPC (expressed as OR ±95% CI) was adjusted for age, sex, education level, dialect, residential area, family history of NPC, pack-years smoked, salted fish and preserved vegetables consumption. The boundaries for each genetic risk score quintile are shown on the <i>x</i>-axis.</p

Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma

<div><p>Objective</p><p>Myosin light chain 9 (MYL9) is necessary for cytoskeletal dynamics and experimental metastasis, but its expression in esophageal squamous cell carcinoma (ESCC) has not been addressed. We investigated the expression pattern and clinical significance of MYL9 in patients with ESCC.</p><p>Methods</p><p>We examined MYL9 expression using quantitative real-time PCR and western blotting in NE1 immortalized esophageal epithelial cells, ESCC cell lines, and paired ESCC tissues. MYL9 protein in 136 primary ESCC tissues and other types of solid tumor was detected using immunohistochemistry. The association between MYL9 expression and clinical parameters and survival was evaluated by statistical analysis.</p><p>Results</p><p>MYL9 was significantly upregulated in the ESCC cell lines as compared with NE1 cells. In the paired ESCC samples, MYL9 mRNA and protein expression was not significantly different between lesion tissues and the matched adjacent noncancerous tissues. In ESCC tissue, both intratumoral and peritumoral stroma were positive for MYL9. In the 136 ESCC samples, high MYL9 expression in the tumor cells significantly correlated with histological differentiation (<i>p</i> = 0.028), recurrence (<i>p</i> = 0.01), and vital status (<i>p</i> < 0.01). Patients with high MYL9 expression in the tumor cells had poorer overall survival (OS) and recurrence-free survival. Multivariate analysis revealed that high MYL9 expression in tumor cells was an independent and significant risk factor affecting OS after curative treatment (hazard ratio = 2.254, 95% confidence interval = 1.347–3.771, <i>p</i> = 0.002).</p><p>Conclusions</p><p>MYL9 expression might be a promising prognostic marker and therapeutic target in ESCC.</p></div