Time-varying system identification using an ultra-orthogonal forward regression and multiwavelet basis functions with applications to EEG

A new parametric approach is proposed for nonlinear and non-stationary system identification based on a time-varying nonlinear autoregressive with exogenous input (TV-NARX) model. The time-varying coefficients of the TV-NARX model are expanded using multi- wavelet basis functions and the model is thus transformed into a time-invariant regression problem. An ultra-orthogonal forward regression (UOFR) algorithm aided by mutual information (MI) is designed to identify a parsimonious model structure and estimate the associated model parameters. The UOFR-MI algorithm which uses not only the observed data themselves but also weak derivatives of the signals is more powerful in model structure detection. The proposed approach combining the advantages of both the basis function expansion method and the UOFR-MI algorithm is proved to be capable of tracking the change of time-varying parameters effectively in both numerical simulations and the real EEG data

Effect of YangZheng XiaoJi Extract, DME-25, on endothelial cells and their response to Avastin.

ackground: Angiogenesis is a cellular process that has been identified as a key target for therapy in solid cancer. However, over the course of anti-angiogenic therapies, cancer cells acquire resistance to these therapies after an initial period of success. DME-25 is an extract from Yang Zheng Xiao Ji, a traditional Chinese medicine that has been reported to benefit patients with cancer by alleviating chemotherapy-associated symptoms and possibly inhibiting key cancer cell traits. This study aimed to explore if DME-25 on its own and in combination with avastin affected endothelial cell behaviour in vitro in the presence of hypoxic lung cancer-conditioned medium (CM). Materials and Methods: Two lung cancer cell lines, A549 and SK-MES-1, were exposed to hypoxic conditions (O2 ≤1%) for 4 h, after which CM, and RNA were collected. Transcript expression of several influential angiogenic markers in lung cancer cells were assessed following hypoxic/normoxic conditions. Lung cancer CM was added in combination with avastin and DME-25, before or after vascular endothelial growth factor (VEGF) depletion, to endothelial cells (HECV) and cell migration and microtubule formation were assessed in vitro. Results: HECV cell migration was reduced in the presence of avastin, although less efficiently in the presence of lung cancer CM. A combination of DME-25 and avastin with lung cancer CM significantly reduced HECV cell migration irrespective of culture under hypoxia or normoxia. Depletion of VEGF from the CM reduced the inhibitory capacity of avastin, however, it appeared to have little impact on the anti-angiogenic effects of DME-25. Conclusion: DME-25 inhibits tubule formation irrespectively of the factors secreted by normoxic or hypoxic lung cancer cell CM depleted of VEGF

Two-Step Sintering of Ceramics with Constant Grain-Size, II: BaTiO\u3csub\u3e3\u3c/sub\u3eand Ni–Cu–Zn Ferrite

We investigated the preparation of bulk dense nanocrystalline BaTiO3 and Ni–Cu–Zn ferrite ceramics using an unconventional two-step sintering strategy, which offers the advantage of not having grain growth while increasing density from about 75% to above 96%. Using nanosized powders, dense ferrite ceramics with a grain size of 200 nm and BaTiO3 with a grain size of 35 nm were obtained by two-step sintering. Like the previous studies on Y2O3, the different kinetics between densification diffusion and grain boundary network mobility leaves a kinetic window that can be utilized in the second-step sintering. Evidence indicates that low symmetry, ferroelectric structures still exist in nanograin BaTiO3 ceramics, and that saturation magnetization is the same in nanograin and coarse grain ferrite ceramics

Enhanced production of intracellular dextran dextrinase from Gluconobacter oxydans using statistical experimental methods

Optimization of the fermentation medium for DDase production by Gluconaobacter oxydans M5 was carried out in the shake flasks using two kinds of statistical methods. Four variables, namely glucose, tryptone, yeast extract and sodium chloride, were found to influence DDase production significantly by the Plackett-Burman screening. A four-factor five-level central composite design (CCD) was chosen to explain the combined effects of the four medium constituents. The optimum medium consisted of glucose (17.670 g/L), maltobiose (30 g/L), tryptone (12.198 g/L), yeast extract (13.528 g/L), ammonium nitrate (15 g/L), copper sulfate (0.01 g/L), zinc sulfate (0.01 g/L), and sodium chloride (0.009 g/L); the initial pH 6.0 was set prior to sterilization. The DDase yield obtained from optimized medium increased by 17-fold (0.238 U/mL) or so. Under these optimal conditions, the experimental values agreed with the predicted values, indicating that the chosen method of optimization of medium composition was efficient, relatively simple, time reducing and material saving

Monitoring Hydrogen Evolution Reaction Intermediates of Transition Metal Dichalcogenides via Operando Raman Spectroscopy

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A deeper understanding of the water-splitting hydrogen evolution reaction (HER) mechanism during photocatalytic processes is crucial for the rational design of efficient photocatalysts. In particular, the HER mechanism promoted by multielement hybrid structures remains extremely challenging and elusive. Herein, an in situ photoelectrochemical/Raman measurement system is employed to monitor the HER mechanism of hybrid nanostructures under realistic working conditions via operando Raman spectra and linear-sweep voltammetry curves. As a proof of concept, tunable composition transition metal dichalcogenides MoS2xSe2(1−x) nanosheets are used as a model photocatalyst to unveil the corresponding photocatalytic mechanism. The spectroscopic studies reveal that hydrogen atoms can be adsorbed to active sulfur and selenium atoms via intermediate species formed during the photocatalytic process. More importantly, the studies demonstrate that an exponential relationship exists between the number of reactive electrons and the Raman intensity of intermediate species, which can serve as a guideline to directly evaluate the HER performance in photocatalysts by comparing the Raman intensities of the intermediate species. As a simple, intuitive, and general analytical method, the designed operando Raman measurement approach provides a new tool for elucidating catalytic reaction mechanisms in a realistic and complex environment; and strategically improving H2 production performance of multielement photocatalysts

High-capacity quantum secure direct communication based on quantum hyperdense coding with hyperentanglement

We present a quantum hyperdense coding protocol with hyperentanglement in polarization and spatial-mode degrees of freedom of photons first and then give the details for a quantum secure direct communication (QSDC) protocol based on this quantum hyperdense coding protocol. This QSDC protocol has the advantage of having a higher capacity than the quantum communication protocols with a qubit system. Compared with the QSDC protocol based on superdense coding with $d$-dimensional systems, this QSDC protocol is more feasible as the preparation of a high-dimension quantum system is more difficult than that of a two-level quantum system at present.Comment: 5 pages, 2 figur

Dual Spaces of Resonance In Thick p−p-Branes

In this work we consider $q-$form fields in a $p-$brane embedded in a $D=(p+2)$ space-time. The membrane is generated by a domain wall in a Randall-Sundrum-like scenario. We study conditions for localization of zero modes of these fields. The expression agrees and generalizes the one found for the zero, one, two and three-forms in a $3-$brane. By a generalization we mean that our expression is valid for any form in an arbitrary dimension with codimension one. We also point out that, even without the dilaton coupling, some form fields are localized in the membrane. The massive modes are considered and the resonances are calculated using a numerical method. We find that different spaces have identical resonance structures, which we call dual spaces of resonances(DSR).Comment: 15 page

Isoscaling in the Lattice Gas Model

The isoscaling behavior is investigated using the isotopic/isobaric yields from the equilibrated thermal source which is prepared by the lattice gas model for lighter systems with A = 36. The isoscaling parameters $\alpha$ and -$\beta$ are observed to drop with temperature. The difference of neutron and proton chemical potential shows a turning point around 5 MeV where the liquid gas phase transition occurs in the model. The relative free neutron or proton density shows a nearly linear relation with the N/Z (neutron to proton ratio) of system and the isospin fractionation is observed.Comment: 5 figures, 5 pages; the final version to appear in Phys Rev