A Review on Interesting Properties of Chicken Feather as Low-Cost Adsorbent

Adsorption process has been used widely in the treatments related to environmental issues due to its modestness and ease of operation. Through the years, the development of low-cost absorbents has been given much attention in the adsorption process. The applications of chicken feather, a byproduct in poultry farming on wastewater treatment are boon for the worldwide researchers. In this review paper, the possible mechanism of adsorption, the adsorption isotherms and the factors affecting the adsorption process are first discussed. Next, this paper provides a review on the potential low-cost adsorbent of chicken feather: its composition, morphological structure and properties. This paper also describes the preparation of chicken feather as an adsorbent with different activation methods. The unique morphological structure of chicken feather enhances its interesting properties for several types of applications purposes. Lastly, the applications of chicken feather proved by the past studies are presented in this paper

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Tsunami Flow Characteristics And Design Load Equations For Residential Buildings Located At Malaysian Coastline

Tsunami-induced damage of building has been evidentially demonstrated by the post-tsunami surveys worldwide, including Malaysia. Up to present, buildings located at Malaysian coastline are not tsunami proof and are susceptible to the future tsunami threat. Motivated by the above concerns, hydraulic experiment and numerical simulation were conducted to evaluate the tsunami impact on a Malaysian typical single-storey residential building at a reduced scale of 1:50. Nominal wave conditions with wave-overtopping and non-overtopping cases were tested to study its effects in combination with each building model type with and without opening. Hydraulic experimental results demonstrated that the building model with a gabled roof had a 12% increment and 52% reduction of the force induced on the front and back faces, respectively. As the tsunami wave flowed through a building model, the induced force on an internal wall’s front face increased up to 50% as the front opening size increased from 15% to 35%, whereas a decrement up to 30% was demonstrated as the internal wall moved from 60 mm to 180 mm. For the back face of an internal wall, the force interrelated with each parameter of front and back opening and the internal wall configuration. For the worst scenario where an internal wall was positioned near a smaller back opening, the back face force on the internal wall increased up to 100% as the front opening increases from 15% to 35%. For tsunami modelling, a three-dimensional higher-order numerical model (VSIAM3+TM) was developed, in view of challenges in simulating the tsunami wave propagation and its impulsive motion during impact on a vertical wall. Based on the combinational approach from the experimental and numerical analysis, empirical equations for wave pressure estimation on the front and back faces of a building were first proposed. For the estimation of tsunami impact on an internal wall’s front face, a new measure of the wake clearance angle (β) was proposed, considering the effect of the front opening and the internal wall configuration. Conversely, a dimensionless factor of front to back opening ratio was proposed, considering the effect of both front and back openings to determine the maximum force on an internal wall’s back face. As there were paucity studies on the tsunami impact on an internal wall, the findings in this study were believed to provide new insight towards the development of the design of a tsunami-resilient building

Mechanical properties, permeability and microstructural characterisation of rice husk ash sustainable concrete with the addition of carbon nanotubes

This study investigated the effects of incorporating carbon nanotubes (CNTs) into rice husk ash (RHA) sustainable concrete on its mechanical properties, permeability and microstructure characterisation. Mechanical test results suggested that the addition of 0.10 % multiwalled CNTs (MWCNTs) yielded optimal results, with increases in the compressive strength, splitting tensile strength, flexural strength, and elastic modulus of the RHA concrete at 28 days of 7 %, 23.81 %, 17.5 %, and 1.0 %, respectively. However, with further addition of MWCNTs, the mechanical properties ultimately deteriorated. Further, the incorporation of CNTs enhanced the long-term performance of RHA sustainable concrete. The addition of 0.1 % MWCNTs and 15 % RHA yielded a 20 %, 14 %, and 66 % decrease in water absorption, porosity, and chloride diffusion coefficient compared to the mixture solely containing 15 % RHA. Scanning electron microscopy of this mixture revealed the filling and bridging effects of MWCNTs between the hydration products have enhanced the performance of RHA sustainable concrete

A Shared Vision on the 2004 Indian Ocean Tsunami in Malaysia: Hazard Assessments, Post-Disaster Measures and Research

The tsunami is one of the deadliest natural disasters, responsible for more than 260,000 deaths and billions in economic losses over the last two decades. The footage of the devastating power of the 2004 Indian Ocean tsunami perhaps remains vivid in the memory of most survivors, and Malaysia was one of the countries affected by the unprecedented 2004 tsunami. It was the first time the Malaysian government had managed such a great disaster. This review, therefore, gathers the relevant literature pertaining to the efforts undertaken following the event of the 2004 tsunami from Malaysia’s perspective. A compilation of post-event observations regarding tsunami characteristics is first presented in the form of maps, followed by building damage, including damage modes of wall failure, total collapse, debris impact and tilting of structures. In addition, hazard assessments and projections regarding a hypothetical future tsunami towards vulnerable hazard zones in Malaysia are reviewed. It is observed that future tsunami risks may originate from the Indian/Burma Plate, Andaman Island, Sunda Trench, Manila Trench, Sulu Trench, Negro Trench, Sulawesi Trench, Cotabato Trench and Brunei slide. A rundown of post-2004 measures and tsunami research undertaken in the country is also included in this review, serving as a reference for disaster management globally. Overall, the outcomes of this review are important for understanding tsunami vulnerability and the resilience of coastal infrastructures, which will be crucial for continued progress in the future

High-Resolution Hydrological-Hydraulic Modeling of Urban Floods Using InfoWorks ICM

Malaysia, being a tropical country located near the equatorial doldrums, experiences the annual occurrence of flood hazards due to monsoon rainfalls and urban development. In recent years, environmental policies in the country have shifted towards sustainable flood risk management. As part of the development of flood forecasting and warning systems, this study presented the urban flood simulation using InfoWorks ICM hydrological−hydraulic modeling of the Damansara catchment as a case study. The response of catchments to the rainfall was modeled using the Probability Distributed Moisture (PDM) model due to its capability for large catchments with long-term runoff prediction. The interferometric synthetic aperture radar (IFSAR) technique was used to obtain high-resolution digital terrain model (DTM) data. The calibrated and validated model was first applied to investigate the effectiveness of the existing regional ponds on flood mitigation. For a 100-year flood, the extent of flooded areas decreased from 12.41 km2 to 3.61 km2 as a result of 64-ha ponds in the catchment, which is equivalent to a 71% reduction. The flood hazard maps were then generated based on several average recurrence intervals (ARIs) and uniform rainfall depths, and the results showed that both parameters had significant influences on the magnitude of flooding in terms of flood depth and extent. These findings are important for understanding urban flood vulnerability and resilience, which could help in sustainable management planning to deal with urban flooding issues

Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791

Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial

Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791

Empagliflozin in Patients with Chronic Kidney Disease

Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo