Structural wave propagation and sound radiation study through time and spatial processing

This work explores new usages of experimental and analysis tools to study the relationship between the wave propagation and sound radiation in a structure with inhomogeneities. The focus of the research is to develop and test new and merged techniques. The analysis tools used in the research include: time domain analysis, k-space analysis, and wave speed tracking. With the time domain analysis, one can study the response of any synthetic excitation with only one set of experimental data. The k-space analysis provides insight into locating areas on a vibrating structure that radiate sound to the acoustic farfield. The wave speed tracking technique was developed to estimate the phase speed of propagating waves in a structure. In addition, the reflection coefficient of a boundary can be computed from the wave speed tracking results. The chirp signal, used in the experiments, provides a concentrated power signal which can excite every mode in the interested frequency range. In addition, the transient property of the chirp signal also provides information in the time domain. A very consistent experimental setup and a repeatable experimental procedure were designed and tested to minimize the errors caused by the setup or mishandling of the equipment;A plate equation with a spatially distributed stress was used to model a structure with inhomogeneities. The results of simulations show that the spatially distributed stress can change the amplitude and wavenumbers of the waves in the plate. A HY-80 steel beam with a T-bar welded to it was investigated experimentally with the proposed tools. The T-bar shows a significant contribution to the radiated sound power, and the existence of the T-bar decreases the phase speed of the propagating waves around the T-bar by 4% to 7%. The heat treatment did not have much influence on the sound radiation or wave phase speed change in this study. The experimental results have proven that the proposed techniques are very useful in the study of wave propagation and sound radiation for structures

Mozart K.448 listening decreased seizure recurrence and epileptiform discharges in children with first unprovoked seizures: a randomized controlled study

BACKGROUND: Increasing numbers of reports show the beneficial effects of listening to Mozart music in decreasing epileptiform discharges as well as seizure frequency in epileptic children. There has been no effective method to reduce seizure recurrence after the first unprovoked seizure until now. In this study, we investigated the effect of listening to Mozart K.448 in reducing the seizure recurrence rate in children with first unprovoked seizures. METHODS: Forty-eight children who experienced their first unprovoked seizure with epileptiform discharges were included in the study. They were randomly placed into treatment (n = 24) and control (n = 24) groups. Children in the treatment group listened to Mozart K.448 daily before bedtime for at least six months. Two patients in the treatment group were excluded from analysis due to discontinuation intervention. Finally, forty-six patients were analyzed. Most of these patients (89.1%) were idiopathic in etiology. Seizure recurrence rates and reduction of epileptiform discharges were compared. RESULTS: The average follow-up durations in the treatment and control groups were 18.6 ± 6.6 and 20.1 ± 5.1 months, respectively. The seizure recurrence rate was estimated to be significantly lower in the treatment group than the control group over 24 months (37.2% vs. 76.8%, p = 0.0109). Significant decreases in epileptiform discharges were also observed after 1, 2, and 6 months of listening to Mozart K.448 when compared with EEGs before listening to music. There were no significant differences in gender, mentality, seizure type, and etiology between the recurrence and non-recurrence groups. CONCLUSIONS: Although the case number was limited and control music was not performed in this study, the study revealed that listening to Mozart K.448 reduced the seizure recurrence rate and epileptiform discharges in children with first unprovoked seizures, especially of idiopathic etiology. We believe that Mozart K.448 could be a promising alternative treatment in patients with first unprovoked seizures and abnormal EEGs. Further large-scaled study should be conducted to confirm the effect. TRIAL REGISTRATION: NCT01892605, date: June-19-201

Fabrication of Antireflection Nanodiamond Particle Film by the Spin Coating Deposition Technique

Diamond-based antireflective (AR) coatings were fabricated using a spin coating of diamond suspension at room temperature as nucleation enhancement procedure and microwave plasma enhanced chemical vapour deposition. Various working pressures were used to investigate their effect on the optical characterization of the as-deposited diamond films. Scanning electron microscopy (SEM) and atomic forced microscopy (AFM) were employed to analyze the surface properties of the diamond films. Raman spectra and transmission electron microscopy (TEM) also were used for analysis of the microstructure of the films. The results showed that working pressure had a significant effect on thickness, surface roughness, and wettability of the as-deposited diamond films. Deposited under 35 Torr or working pressure, the film possessed a low surface roughness of 13.8 nm and fine diamond grain sizes of 35 nm. Reflectance measurements of the films also were carried out using UV-Vis spectrometer and revealed a low reflectance value of the diamond films. The achievement demonstrated feasibility of the proposed spin-coating procedure for large scale production and thus opens up a prospect application of diamond film as an AR coating in industrial optoelectronic device

Preliminary examination of the low-frequency ambient noise field in the South China Sea during the 2001 ASIAEX experiment

Author Posting. © IEEE, 2004. This article is posted here by permission of IEEE for personal use, not for redistribution. The definitive version was published in IEEE Journal of Oceanic Engineering 29 (2004): 1308-1315, doi:10.1109/JOE.2004.836999.This correspondence presents a preliminary examination of the low frequency ambient noise field measured in the South China Sea component of the Asian Seas International Acoustics Experiment (ASIAEX), concentrating on the frequencies of 50, 100, 200, 400, 800, and 1200 Hz. A two-week-long time series of the noise at these frequencies is examined for structure in both the time and frequency domains. Three features of particular interest in these series are: 1) the noise due to a typhoon, which passed near the experimental site, 2) the weak tidal frequency variability of the noise field, which is probably due to internal tide induced variability in the propagation conditions, and 3) the vertical angle dependence of the noise, particularly as regards the shallow water "noise notch" phenomenon. The acoustic frequency dependence and the vertical dependence of the noise field are also examined over the course of the time series. A simple look at the noise variability statistics is presented. Finally, directions for further analysis are discussed.This work was supported by the U.S. Office of Naval Research under Grants N0001498-1-0413, N00014-00-0931, and N00014-01-0772 and by the NSC of Taiwan under Grant NSC92-2611-E110-004-CCS

Betanodavirus Induces Oxidative Stress-Mediated Cell Death That Prevented by Anti-Oxidants and Zfcatalase in Fish Cells

The role of oxidative stress in the pathogenesis of RNA nervous necrosis virus infection is still unknown. Red-spotted grouper nervous necrosis virus (RGNNV) induced free radical species (ROS) production at 12–24 h post-infection (pi; early replication stage) in fish GF-1 cells, and then at middle replication stage (24–48 h pi), this ROS signal may upregulate some expressions of the anti-oxidant enzymes Cu/Zn SOD and catalase, and eventually expression of the transcription factor Nrf2. Furthermore, both antioxidants diphenyliodonium and N-acetylcysteine or overexpression of zebrafish catalase in GF-1 cells also reduced ROS production and protected cells for enhancing host survival rate due to RGNNV infection

The Design and Implementation of the Defender Cloud on TWAREN Backbone

Defender Cloud is a cloud based backbone network defending system having full scope over the whole backbone network. Rather than detecting suspicious network activities on a local area network, it collects and integrates the flow data from all connecting members and all entrances of a backbone network. After analyzing by a proposed cloud based distributed processing model, the corresponding defensive reaction can be carried out in a global basis. Thus its protection can cover the whole network, even including member institutions without their own firewall. This paper illustrates the design, verification and future perspective of the Defender Cloud, with an emphasis on the distributed processing of the flow data

GPER-induced signaling is essential for the survival of breast cancer stem cells.

G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non-BCSCs of three patient-derived xenografts of ER- /PR+ breast cancers. GPER silencing reduced stemness features of BCSCs as reflected by reduced mammosphere forming capacity in vitro, and tumor growth in vivo with decreased BCSC populations. Comparative phosphoproteomics revealed greater GPER-mediated PKA/BAD signaling in BCSCs. Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD-Ser118 to sustain BCSC characteristics. Transfection with a dominant-negative mutant BAD (Ser118Ala) led to reduced cell survival. Taken together, GPER and its downstream signaling play a key role in maintaining the stemness of BCSCs, suggesting that GPER is a potential therapeutic target for eradicating BCSCs

Association of ORAI1 Haplotypes with the Risk of HLA-B27 Positive Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The aetiology of ankylosing spondylitis is still unclear. Previous studies have indicated that genetics factors such as human leukocyte antigen HLA-B27 associates to AS susceptibility. We carried out a case-control study to determine whether the genetic polymorphisms of ORAI1 gene, a major component of store-operated calcium channels that involved the regulation of immune system, is a susceptibility factor to AS in a Taiwanese population. We enrolled 361 AS patients fulfilled the modified New York criteria and 379 controls from community. Five tagging single nucleotides polymorphisms (tSNPs) at ORAI1 were selected from the data of Han Chinese population in HapMap project. Clinical statuses of AS were assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Global Index (BAS-G). Our results indicated that subjects carrying the minor allele homozygote (CC) of the promoter SNP rs12313273 or TT homozygote of the SNP rs7135617 had an increased risk of HLA-B27 positive AS. The minor allele C of 3′UTR SNP rs712853 exerted a protective effect to HLA-B27 positive AS. Furthermore, the rs12313273/rs7135617 pairwise allele analysis found that C-G (OR 1.69, 95% CI 1.27, 2.25; p = 0.0003) and T-T (OR 1.75, 95% CI 1.36, 2.27; p<0.0001) haplotypes had a significantly association with the risk of HLA-B27-positive AS in comparison with the T-G carriers. This is the first study that indicate haplotypes of ORAI1 (rs12313273 and rs7135617) are associated with the risk of HLA-B27 positive AS

Mozart K.545 Mimics Mozart K.448 in Reducing Epileptiform Discharges in Epileptic Children

Mozart K.448 has been shown to improve cognitive function, leading to what is known as the Mozart Effect. Our previous work reveals positive effects of Mozart K.448 in reducing epileptiform discharges in epileptic children. In this study, we evaluated the effect of Mozart K.545 and compared the effects with those of Mozart K.448 on epileptiform discharges in children with epilepsy. Thirty-nine epileptic children with epileptiform discharges were included in the study. They received electroencephalogram examinations before, during, and after listening to Mozart K.448 and K.545, one week apart, respectively. The frequencies of epileptiform discharges were compared. There was a significant decrease in the frequency of epileptiform discharges during and right after listening to Mozart K.448 and K.545 (reduced by 35.7±32.7% during Mozart K.448 and 30.3±44.4% after Mozart K.448; and 34.0±39.5% during Mozart K.545 and 31.8±39.2% after Mozart K.545). Spectrogrammatic analysis of the two pieces of music demonstrated that both share similar spectrogrammatic characteristics. Listening to Mozart K.448 and K.545 decreased the epileptiform discharges in epileptic children. This suggests that Mozart K.448 is not the only piece of music to have beneficial effects on children with epilepsy. Other music with lower harmonics may also decrease epileptiform discharges in epileptic children