When is there a strong transfer risk from the sovereigns to the corporates?

When a sovereign faces the risk of debt default, it may be tempted to expropriate the private sector. This may be one reason why international investment in private companies has to take into account the sovereign risk. But the likelihood of sovereign risk transferring to corporates and increasing their risk of default may be mitigated by legal institutions that provide strong property rights protection. Using a novel credit default swaps (CDS) data set covering government and corporate entities across thirty countries, we study both the average strength of the transfer risks and the role of institutions in mitigating such risks. We find that 1) sovereign risk on average has a statistically and economically significant influence on corporate credit risks (all else equal, a 100 basis point increase in the sovereign CDS spread leads to an increase in corporate CDS spreads of 71 basis points); 2) the sovereign-corporate relation varies across corporations, with state-owned companies exhibiting a stronger relation with the sovereign; and 3) the presence of strong property rights institutions, however, tends to weaken the connection. In contrast, contracting institutions (offering protection of creditor rights or minority shareholder rights) do not appear to matter much in this context

The Effect of Race/Ethnicity on the Age of Colon Cancer Diagnosis

ABSTRACT BACKGROUND: Colorectal cancer is the third most commonly diagnosed cancer in the United States. Notably, racial/ethnic disparities exist in both incidence and mortality. PURPOSE: The aim of this case study was to investigate the impact of race/ethnicity on age at diagnosis of colorectal cancer in a defined population in Suffolk County, NY. METHODS: Data were retrospectively collected on race/ethnicity, health insurance status, age at diagnosis, stage at diagnosis, gender, smoking status, alcohol intake, tumor location, and body mass index for colorectal cancer patients with medical records in the Stony Brook University Medical Center database (2005-2011). Population-based data on Hispanic and non-Hispanic Whites were obtained from the Surveillance, Epidemiology, and End Results registry of New York State for an overlapping time period. Permutation-based ANCOVA and logistic regression with stepwise variable selection were conducted to identify covariates and first-order interactions associated with younger age at diagnosis and cancer stage as a dependent categorical variable. RESULTS: Of 328 colorectal cancer patients, Hispanics were diagnosed at a median younger age of 57y vs. 67y than non-Hispanic Whites (FDR = 0.001). Twenty-six percent of Hispanics were diagnosed with colorectal cancer prior to the recommended age (50y) for colorectal cancer surveillance compared to 11% of non-Hispanic Whites (FDR =0.007). Analysis of New York State registry data corroborated our findings that Hispanic colorectal cancer patients were diagnosed at a median younger age than non-Hispanic Whites. Permutation-based ANCOVA identified race/ethnicity and health insurance as significantly associated with age of diagnosis (P=0.001). Logistic regression selected (younger) age at diagnosis as being significantly associated with stage IV disease. The limitations of the case study reside in the use of self-reporting of race and ethnicity and in the small sample sizes. CONCLUSIONS: Hispanics may be at higher risk for colorectal cancer (y) and younger age at diagnosis is associated with advanced disease

The Role of Job Embeddedness in “New Generation of Rural Migrant Workers” Turnover Intention in China

The high voluntary turnover rates of “new generation of rural migrant workers” have been widely concerned in China. One important reason is their rural identity. The distinctive social identity has caused new generation of rural migrant workers face social identity discrimination, which further hinder the integration of values and goals between the individuals and the organizations. The values and goals gap between individuals and organizations further impact on new generation of rural migrant workers’ organizational identification, which reduce their organization embeddedness and increase turnover intention. Thus, this study seeks to explore the linkage between organization identification and turnover intention, which is mediated by organizational embeddedness. Additionally, this study also proposes the moderating effect of community embeddedness on the correlation between organization embeddedness and turnover intention. A quantitative with a survey method is proposed for this study. Data will be collected in manufacturing setting in Guizhou province of China. Multi-level sampling technique will be applied to determine the sample size

The impact of antifibrotic use on long-term clinical outcomes in the pulmonary fibrosis foundation registry

Background: Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) with a high mortality rate. The antifibrotic medications pirfenidone and nintedanib have been in use since 2014 for this disorder and are associated with improved rate of lung function decline. Less is known about their long-term outcomes outside of the clinical trial context. Methods: The Pulmonary Fibrosis Foundation Patient Registry was used for this study. Patients with an IPF diagnosis made within a year of enrollment were included. The treated group was defined as patients receiving either pirfenidone or nintedanib for at least 180 days. The untreated group did not have any record of antifibrotic use. Demographic data, comorbidities, serial lung function, hospitalization, and vital status data were collected from the registry database. The primary outcomes were transplant-free survival, time to first respiratory hospitalization, and time to 10% absolute FVC decline. Time-to-event analyses were performed utilizing Cox proportional hazards models and the log-rank test. Model covariates included age, gender, smoking history, baseline lung function, comorbidities, and oxygen use. Results: The registry contained 1212 patients with IPF; ultimately 288 patients met inclusion criteria for the treated group, and 101 patients were designated as untreated. Patients treated with antifibrotics were significantly younger (69.8 vs. 72.6 years, p = 0.008) and less likely to have smoked (61.1% ever smokers vs. 72.3% never smokers, p = 0.04). No significant differences were seen in race, gender, comorbidities, or baseline pulmonary function between groups. The primary outcome of transplant-free survival was not significantly different between the two groups (adjusted HR 0.799, 95% CI 0.534-1.197, p = 0.28). Time to respiratory hospitalization was significantly shorter in the treated group (adjusted HR 2.12, 95% CI 1.05-4.30, p = 0.04). No significant difference in time to pulmonary function decline was seen between groups. Conclusions: This multicenter study demonstrated 63% of newly diagnosed IPF patients had continuous antifibrotic usage. Antifibrotics were not associated with improved transplant-free survival or pulmonary function change but was associated with an increased hazard of respiratory hospitalization. Future studies should further investigate the role of antifibrotic therapy in clinically important outcomes in real-world patients with IPF and other progressive ILDs.</p

The effect of organizational identification on job embeddedness: evidence from new generation of rural migrant workers in China

The purpose of this paper was to examine the relationships among work overload (WO), compensation (COM), organizational identification (OI) and organization embeddedness (OE) in the context of manufacturing industry in China through social identity theory. A 37-item questionnaire was filled by 384 new generation of rural migrant workers. Data were examined through a two-stage of first-order of reflective model and second-order reflective-formative hierarchical model using PLS-SEM. The empirical results indicate that COM and OI positively and significantly predicted OE, while WO was found to have no direct effect on OE. In addition, COM positively and significantly was associated with OI, whereas WO affected OI, negatively. Further examination of the mediation effects of OI revealed that OI could fully mediate the relationship between WO and OE. Moreover, OI also had a partial mediator role in the relationship between COM and OE. The study concluded with several implications and recommendations for future research

A comprehensive profile analysis of the effect of job embeddedness on turnover intention among new generation of rural migrant workers in China: based on PLS-SEM

This paper aimed to examine the relationship between organization embeddedness (OE), community embeddedness (CE) and turnover intention in the context of manufacturer sector in China. A 37-item questionnaire was filled by 384 new generation of rural migrant workers. Data were examined through a first-order of reflective model (SME1) and a two-stage of second-order reflective-formative hierarchical model (SME2) with the technical of Partial Least Squares. The empirical test results indicated that both OE and CE negative and significant related to turnover intention. When further disaggregated the components of OE and CE into the three sub-dimensions of fit, links, and sacrifice, this study found that causal indicator model of job embeddedness predict more variance of turnover intention than reflective model. Moreover, this study found that OEF, OES, CEF, and CES negative and significantly associated with turnover intention, while OEL positive related to turnover intention. Additionally, CEL did not show significant impact on turnover intention. The study concludes with several implications and recommendations for future research

The role of job embeddedness in new generation migrant workers turnover intention in Guizhou province of China

Nowadays, new generation migrant workers have become the major component of migrant workers in China.As an important part of China’s labor force supply, new generation migrant workers’ high voluntary turnover rates have been widely concerned.Identified by the household registration system and land contract system in China, although migrant workers work in non-agricultural sectors, they still hold rural resident household registration.Due to this different social identity with the urban workers, new generation migrant workers usually face identity discrimination (difference between farmers and urban workers) and are difficult to integrate into their working organization.The rural resident household registration acts as a potentially salient social category with which new generation migrant workers can develop identification in their organizations, by which they identify the congruence of values and goals between individual and the organization that contribute to their work enthusiasm and organizational commitment and later lead to frequently job change.Thus, this study seeks to investigate the relationship between organization identification and turnover intentions in the sample of new generation migrant workers, which is mediated by on-the-job embeddedness.Additionally, this study also tests the moderating effect of off-the-job embeddedness on the relationship between on-the-job embeddedness and turnover intention

Capturing coastal water clarity variability with Landsat 8

© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Luis, K. M. A., Rheuban, J. E., Kavanaugh, M. T., Glover, D. M., Wei, J., Lee, Z., & Doney, S. C. Capturing coastal water clarity variability with Landsat 8. Marine Pollution Bulletin, 145, (2019): 96-104, doi: 10.1016/j.marpolbul.2019.04.078.Coastal water clarity varies at high temporal and spatial scales due to weather, climate, and human activity along coastlines. Systematic observations are crucial to assessing the impact of water clarity change on aquatic habitats. In this study, Secchi disk depths (ZSD) from Boston Harbor, Buzzards Bay, Cape Cod Bay, and Narragansett Bay water quality monitoring organizations were compiled to validate ZSD derived from Landsat 8 (L8) imagery, and to generate high spatial resolution ZSD maps. From 58 L8 images, acceptable agreement was found between in situ and L8 ZSD in Buzzards Bay (N = 42, RMSE = 0.96 m, MAPD = 28%), Cape Cod Bay (N = 11, RMSE = 0.62 m, MAPD = 10%), and Narragansett Bay (N = 8, RMSE = 0.59 m, MAPD = 26%). This work demonstrates the value of merging in situ ZSD with high spatial resolution remote sensing estimates for improved coastal water quality monitoring.This work was supported by the John D. and Catherine T. MacArthur Foundation (grant 14-106159-000-CFP) and by the National Science Foundation grant DGE 1249946, Integrative Graduate Education and Research Traineeship (IGERT): Coasts and Communities – Natural and Human Systems in Urbanizing Environments. Lastly, we are indebted to the Massachusetts Water Resources Authority, Buzzards Bay Coalition, Provincetown Center for Coastal Studies, Narragansett Bay Commission, and the numerous citizen scientists responsible for collecting the in situ measurements used in this study. Comments and suggestions from our anonymous reviewer were greatly appreciated

Study protocol: a cluster randomized controlled trial of web-based decision support tools for increasing BRCA1/2 genetic counseling referral in primary care

Background BRCA1 and BRCA2 mutations confer a substantial breast risk of developing breast cancer to those who carry them. For this reason, the United States Preventative Services Task Force (USPSTF) has recommended that all women be screened in the primary care setting for a family history indicative of a mutation, and women with strong family histories of breast or ovarian cancer be referred to genetic counseling. However, few high-risk women are being routinely screened and fewer are referred to genetic counseling. To address this need we have developed two decision support tools that are integrated into clinical care. Method This study is a cluster randomized controlled trial of high-risk patients and their health care providers. Patient-provider dyads will be randomized to receive either standard education that is supplemented with the patient-facing decision aid, RealRisks, and the provider-facing Breast Cancer Risk Navigation Toolbox (BNAV) or standard education alone. We will assess these tools’ effectiveness in promoting genetic counseling uptake and informed and shared decision making about genetic testing. Discussion If found to be effective, these tools can help integrate genomic risk assessment into primary care and, ultimately, help expand access to risk-appropriate breast cancer prevention options to a broader population of high-risk women. Trial registration This trial is retrospectively registered with ClinicalTrials.gov Identifier: NCT03470402 : 20 March 2018

Differential expression of miRNAs in colon cancer between African and Caucasian Americans: Implications for cancer racial health disparities

Colorectal cancer (CRC) incidence and mortality are higher in African Americans (AAs) than in Caucasian Americans (CAs) and microRNAs (miRNAs) have been found to be dysregulated in colonic and other neoplasias. The aim of this exploratory study was to identify candidate miRNAs that could contribute to potential biological differences between AA and CA colon cancers. Total RNA was isolated from tumor and paired adjacent normal colon tissue from 30 AA and 31 CA colon cancer patients archived at Stony Brook University (SBU) and Washington University (WU)-St. Louis Medical Center. miRNA profiles were determined by probing human genome-wide miRNA arrays with RNA isolated from each sample. Using repeated measures analysis of variance (RANOVA), miRNAs were selected that exhibited significant (p<0.05) interactions between race and tumor or significant (fold change >1.5, p<0.05) main effects of race and/or tumor. Quantitative polymerase chain reaction (q-PCR) was used to confirm miRNAs identified by microarray analysis. Candidate miRNA targets were analyzed using immunohistochemistry. RANOVA results indicated that miR-182, miR152, miR-204, miR-222 and miR-202 exhibited significant race and tumor main effects. Of these miRNAs, q-PCR analysis confirmed that miR-182 was upregulated in AA vs. CA tumors and exhibited significant race:tumor interaction. Immunohistochemical analysis revealed that the levels of FOXO1 and FOXO3A, two potential miR-182 targets, are reduced in AA tumors. miRNAs may play a role in the differences between AA and CA colon cancer. Specifically, differences in miRNA expression levels of miR-182 may contribute to decreased survival in AA colon cancer patients