A kilonova associated with GRB 070809

For on-axis typical short gamma-ray bursts (sGRBs), the forward shock emission is usually so bright that renders the identification of kilonovae (also known as macronovae) in the early afterglow ($t<0.5$ d) phase rather challenging. This is why previously no thermal-like kilonova component has been identified at such early time except in the off-axis dim GRB 170817A associated with GW170817. Here we report the identification of an unusual optical radiation component in GRB 070809 at $t\sim 0.47$ d, thanks plausibly to the very-weak/subdominant forward shock emission. The optical emission with a very red spectrum is well in excess of the extrapolation of the X-ray emission that is distinguished by an unusually hard spectrum, which is at odds with the forward shock afterglow prediction but can be naturally interpreted as a kilonova. Our finding supports the speculation that kilonovae are ubiquitous , and demonstrates the possibility of revealing the neutron star merger origin with the early afterglow data of some typical sGRBs that take place well beyond the sensitive radius of the advanced gravitational wave detectors and hence the opportunity of organizing dedicated follow-up observations for events of interest.Comment: 20 pages, 5 figures, published in Nature Astronom

Anticancer potentials of sinomenine from Sinomenium acutum: A mini-review

Sinomenine, an important isoquinoline from Sinomenium acutum (Menispermaceae), is currently considered as a reliable drug for treating various malignant cancers including breast cancer, colon cancer, lung cancer, liver cancer, gastric cancer, osteosarcoma cervical cancer, and esophageal cancer. The pharmacological mechanisms are probably related to induction of apoptosis and cell cycle arrest. This paper was aimed at reviewing the anticancer potential of sinomenine, which is expected to be beneficial in developing this compound as a candidate drug for cancer therapy.Keywords: Sinomenine, Anticancer, Sinomenium acutum, Traditional Chinese Medicin

A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol

Menthol is a widely-used cooling and flavoring agent derived from mint leaves. In the peripheral nervous system, menthol regulates sensory transduction by activating TRPM8 channels residing specifically in primary sensory neurons. Although behavioral studies have implicated menthol actions in the brain, no direct central target of menthol has been identified. Here we show that menthol reduces the excitation of rat hippocampal neurons in culture and suppresses the epileptic activity induced by pentylenetetrazole injection and electrical kindling in vivo. We found menthol not only enhanced the currents induced by low concentrations of GABA but also directly activated GABAA receptor (GABAAR) in hippocampal neurons in culture. Furthermore, in the CA1 region of rat hippocampal slices, menthol enhanced tonic GABAergic inhibition although phasic GABAergic inhibition was unaffected. Finally, the structure-effect relationship of menthol indicated that hydroxyl plays a critical role in menthol enhancement of tonic GABAAR. Our results thus reveal a novel cellular mechanism that may underlie the ambivalent perception and psychophysical effects of menthol and underscore the importance of tonic inhibition by GABAARs in regulating neuronal activity

Degradation of Decabromodiphenyl Ether in an Aerobic Clay Slurry Microcosm Using a Novel Immobilization Technique

A novel chitosan immobilization technique that entraps photocatalyst and microbes was developed and applied to decompose decabromodiphenyl ether (BDE-209) in a clay slurry microcosm. The optimized conditions for immobilization were obtained by mixing 1.2% (w/v) chitosan dissolved in 1% (v/v) acetic acid with nano-TiO2 particles and the BDE-209-degrading bacterial mixed culture. This aqueous mixture was injected into 1% (w/v) water solution containing sodium tripolyphosphate to form spherical immobilized beads. The surface of the immobilized beads was reinforced by 0.25% (v/v) glutaraldehyde cross-linking. These beads had enough mechanical strength during BDE-209 degradation to maintain their shape in the system at a stirring rate of 200-rpm, while undergoing continuous 365 nm UVA irradiation. This novel TiO2-Yi-Li immobilized chitosan beads system allowed a successful simultaneous integration of photolysis, photocatalysis and biodegradation to remove BDE-209. The remaining percentage of BDE-209 was 41% after 70 days of degradation using this system. The dominant bacteria in the BDE-209-degrading bacterial mixed culture during remediation were Chitinophaga spp., Methyloversatilis spp., Terrimonas spp. and Pseudomonas spp. These bacteria tolerated the long-term UVA irradiation and high-level free radicals present, while utilizing BDE-209 as their primary carbon resource. This new method has great potential for the treatment of a range of pollutants