2,850 research outputs found
Plasma dynamics of the Earth magnetopause-boundary layer and its coupling to the polar ionosphere
Thesis (Ph.D.) University of Alaska Fairbanks, 1991In this thesis, the plasma dynamics of the Earth magnetopause-boundary layer and its coupling to the polar ionosphere are studied by using computer simulations. First, the plasma dynamics and structure of the magnetopause-boundary layer are studied by a two-dimensional incompressible magnetohydrodynamic simulation code. It is found that the Kelvin-Helmholtz instability with driven boundary conditions at the magnetopause can lead to the formation of plasma vortices observed in the magnetopause-boundary layer. In the later stage of development, a density plateau is formed in the central part of the boundary layer. Second, the coupling of plasma vortices formed in the boundary layer to the polar ionosphere is studied based on a magnetosphere-ionosphere coupling model. The finite ionospheric conductivity provides a dragging force to the plasma flow and leads to the decay of plasma vortices in the boundary layer. In the model, the ionospheric conductivity is allowed to be enhanced due to accelerated electrons precipitating in upward field-aligned current regions. The competing effect of the formation and decay of vortices leads to the formation of strong vortices only in limited regions. Several enhanced conductivity regions are formed along the post-noon auroral oval, which may account for the observed auroral bright spots. In addition, the evolution of localized plasma vortices, as well as magnetic flux ropes, along magnetic field lines is studied. The evolution leads to the generation of large-amplitude Alfven waves, which carry field-aligned currents and provide the link for the coupling of plasma vortices and magnetic flux ropes in the magnetosphere to the polar ionosphere
The multiplexed light storage of Orbital Angular Momentum based on atomic ensembles
The improvement of the multi-mode capability of quantum memory can further
improve the utilization efficiency of the quantum memory and reduce the
requirement of quantum communication for storage units. In this letter, we
experimentally investigate the multi-mode light multiplexing storage of orbital
angular momentum (OAM) mode based on rubidium vapor, and demultiplexing by a
photonic OAM mode splitter which combines a Sagnac loop with two dove prisms.
Our results show a mode extinction ratio higher than 80 at 1 s of
storage time. Meanwhile, two OAM modes have been multiplexing stored and
demultiplexed in our experimental configuration. We believe the experimental
scheme may provide a possibility for high channel capacity and multi-mode
quantum multiplexed quantum storage based on atomic ensembles
In vitro drug release behavior from a novel thermosensitive composite hydrogel based on Pluronic f127 and poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) copolymer
<p>Abstract</p> <p>Background</p> <p>Most conventional methods for delivering chemotherapeutic agents fail to achieve therapeutic concentrations of drugs, despite reaching toxic systemic levels. Novel controlled drug delivery systems are designed to deliver drugs at predetermined rates for predefined periods at the target organ and overcome the shortcomings of conventional drug formulations therefore could diminish the side effects and improve the life quality of the patients. Thus, a suitable controlled drug delivery system is extremely important for chemotherapy.</p> <p>Results</p> <p>A novel biodegradable thermosensitive composite hydrogel, based on poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) and Pluronic F127 copolymer, was successfully prepared in this work, which underwent thermosensitive sol-gel-sol transition. And it was flowing sol at ambient temperature but became non-flowing gel at body temperature. By varying the composition, sol-gel-sol transition and <it>in vitro </it>drug release behavior of the composite hydrogel could be adjusted. Cytotoxicity of the composite hydrogel was conducted by cell viability assay using human HEK293 cells. The 293 cell viability of composite hydrogel copolymers were yet higher than 71.4%, even when the input copolymers were 500 μg per well. Vitamin B<sub>12 </sub>(VB<sub>12</sub>), honokiol (HK), and bovine serum albumin (BSA) were used as model drugs to investigate the <it>in vitro </it>release behavior of hydrophilic small molecular drug, hydrophobic small molecular drug, and protein drug from the composite hydrogel respectively. All the above-mentioned drugs in this work could be released slowly from composite hydrogel in an extended period. Chemical composition of composite hydrogel, initial drug loading, and hydrogel concentration substantially affected the drug release behavior. The higher Pluronic F127 content, lower initial drug loading amount, or lower hydrogel concentration resulted in higher cumulative release rate.</p> <p>Conclusion</p> <p>The results showed that composite hydrogel prepared in this paper were biocompatible with low cell cytotoxicity, and the drugs in this work could be released slowly from composite hydrogel in an extended period, which suggested that the composite hydrogel might have great potential applications in biomedical fields.</p
Physics perspectives of heavy-ion collisions at very high energy
Heavy-ion collisions at very high colliding energies are expected to produce
a quark-gluon plasma (QGP) at the highest temperature obtainable in a
laboratory setting. Experimental studies of these reactions can provide an
unprecedented range of information on properties of the QGP at high
temperatures. We report theoretical investigations of the physics perspectives
of heavy-ion collisions at a future high-energy collider. These include initial
parton production, collective expansion of the dense medium, jet quenching,
heavy-quark transport, dissociation and regeneration of quarkonia, photon and
dilepton production. We illustrate the potential of future experimental studies
of the initial particle production and formation of QGP at the highest
temperature to provide constraints on properties of strongly interaction
matter.Comment: 35 pages in Latex, 29 figure
Gene Expression Profiles in Genetically Different Mice Infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU
Toxoplasma gondii can modulate host cell gene expression; however, determining gene expression levels in intermediate hosts after T. gondii infection is not known much. We selected 5 genes (ALDH1A2, BEX2, CCL3, EGR2 and PLAU) and compared the mRNA expression levels in the spleen, liver, lung and small intestine of genetically different mice infected with T. gondii. ALDH1A2 mRNA expressions of both mouse strains were markedly increased at day 1-4 postinfection (PI) and then decreased, and its expressions in the spleen and lung were significantly higher in C57BL/6 mice than those of BALB/c mice. BEX2 and CCR3 mRNA expressions of both mouse strains were significantly increased from day 7 PI and peaked at day 15-30 PI (P<0.05), especially high in the spleen liver or small intestine of C57BL/6 mice. EGR2 and PLAU mRNA expressions of both mouse strains were significantly increased after infection, especially high in the spleen and liver. However, their expression patterns were varied depending on the tissue and mouse strain. Taken together, T. gondii-susceptible C57BL/6 mice expressed higher levels of these 5 genes than did T. gondii-resistant BALB/c mice, particularly in the spleen and liver. And ALDH1A2 and PLAU expressions were increased acutely, whereas BEX2, CCL3 and EGR2 expressions were increased lately. Thus, these demonstrate that host genetic factors exert a strong impact on the expression of these 5 genes and their expression patterns were varied depending on the gene or tissue
LQTS Gene LOVD Database
The Long QT Syndrome (LQTS) is a group of genetically heterogeneous disorders that predisposes young individuals to ventricular arrhythmias and sudden death. LQTS is mainly caused by mutations in genes encoding subunits of cardiac ion channels (KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2). Many other genes involved in LQTS have been described recently (KCNJ2, AKAP9, ANK2, CACNA1C, SCNA4B, SNTA1, and CAV3). We created an online database (http://www.genomed.org/LOVD/introduction.html) that provides information on variants in LQTS-associated genes. As of February 2010, the database contains 1738 unique variants in 12 genes. A total of 950 variants are considered pathogenic, 265 are possible pathogenic, 131 are unknown/unclassified, and 292 have no known pathogenicity. In addition to these mutations collected from published literature, we also submitted information on gene variants, including one possible novel pathogenic mutation in the KCNH2 splice site found in ten Chinese families with documented arrhythmias. The remote user is able to search the data and is encouraged to submit new mutations into the database. The LQTS database will become a powerful tool for both researchers and clinicians. © 2010 Wiley-Liss, Inc
Constraints on holographic dark energy from X-ray gas mass fraction of galaxy clusters
We use the Chandra measurements of the X-ray gas mass fraction of 26 rich
clusters released by Allen et al. to perform constraints on the holographic
dark energy model. The constraints are consistent with those from other
cosmological tests, especially with the results of a joint analysis of
supernovae, cosmic microwave background, and large scale structure data. From
this test, the holographic dark energy also tends to behave as a quintom-type
dark energy.Comment: 5 pages, 3 figures; to appear in Phys. Lett.
3, 4-dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury.
The present study aimed to detect the role of 3, 4-dihydroxyl-phenyl lactic acid (DLA) during ischemia/reperfusion (I/R) induced myocardial injury with emphasis on the underlying mechanism of DLA antioxidant. Male Spragu-Dawley (SD) rats were subjected to left descending artery occlusion followed by reperfusion. Treatment with DLA ameliorated myocardial structure and function disorder, blunted the impairment of Complex I activity and mitochondrial function after I/R. The results of 2-D fluorescence difference gel electrophoresis revealed that DLA prevented the decrease in NDUFA10 expression, one of the subunits of Complex I. To find the target of DLA, the binding affinity of Sirtuin 1 (SIRT1) to DLA and DLA derivatives with replaced two phenolic hydroxyls was detected using surface plasmon resonance and bilayer interferometry. The results showed that DLA could activate SIRT1 after I/R probably by binding to this protein, depending on phenolic hydroxyl. Moreover, the importance of SIRT1 to DLA effectiveness was confirmed through siRNA transfection in vitro. These results demonstrated that DLA was able to prevent I/R induced decrease in NDUFA10 expression, improve Complex I activity and mitochondrial function, eventually attenuate cardiac structure and function injury after I/R, which was possibly related to its ability of binding to and activating SIRT1
Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults
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