Baseline and admitting characteristics by race, and by ethnicity.

Baseline and admitting characteristics by race, and by ethnicity.</p

Unadjusted and adjusted odds of receiving COVID-19 treatments at admission by race, ethnicity, and race stratified by ethnicity.

Unadjusted and adjusted odds of receiving COVID-19 treatments at admission by race, ethnicity, and race stratified by ethnicity.</p

CONSORT table.

(TIF)</p

Baseline and admitting characteristics by race, and by ethnicity (full results).

(DOCX)</p

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

International audienc