Factors Influencing the Participation of Older People in Clinical Trials : Data Analysis from the MAVIS Trial

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Inflation, cold dark matter, and the central density problem

A problem with high central densities in dark halos has arisen in the context of LCDM cosmologies with scale-invariant initial power spectra. Although n=1 is often justified by appealing to the inflation scenario, inflationary models with mild deviations from scale-invariance are not uncommon and models with significant running of the spectral index are plausible. Even mild deviations from scale-invariance can be important because halo collapse times and densities depend on the relative amount of small-scale power. We choose several popular models of inflation and work out the ramifications for galaxy central densities. For each model, we calculate its COBE-normalized power spectrum and deduce the implied halo densities using a semi-analytic method calibrated against N-body simulations. We compare our predictions to a sample of dark matter-dominated galaxies using a non-parametric measure of the density. While standard n=1, LCDM halos are overdense by a factor of 6, several of our example inflation+CDM models predict halo densities well within the range preferred by observations. We also show how the presence of massive (0.5 eV) neutrinos may help to alleviate the central density problem even with n=1. We conclude that galaxy central densities may not be as problematic for the CDM paradigm as is sometimes assumed: rather than telling us something about the nature of the dark matter, galaxy rotation curves may be telling us something about inflation and/or neutrinos. An important test of this idea will be an eventual consensus on the value of sigma_8, the rms overdensity on the scale 8 h^-1 Mpc. Our successful models have values of sigma_8 approximately 0.75, which is within the range of recent determinations. Finally, models with n>1 (or sigma_8 > 1) are highly disfavored.Comment: 13 pages, 6 figures. Minor changes made to reflect referee's Comments, error in Eq. (18) corrected, references updated and corrected, conclusions unchanged. Version accepted for publication in Phys. Rev. D, scheduled for 15 August 200

Clustering of dark matter tracers: generalizing bias for the coming era of precision LSS

On very large scales, density fluctuations in the Universe are small, suggesting a perturbative model for large-scale clustering of galaxies (or other dark matter tracers), in which the galaxy density is written as a Taylor series in the local mass density, delta, with the unknown coefficients in the series treated as free "bias" parameters. We extend this model to include dependence of the galaxy density on the local values of nabla_i nabla_j phi and nabla_i v_j, where phi is the potential and v is the peculiar velocity. We show that only two new free parameters are needed to model the power spectrum and bispectrum up to 4th order in the initial density perturbations, once symmetry considerations and equivalences between possible terms are accounted for. One of the new parameters is a bias multiplying s_ij s_ji, where s_ij=[nabla_i nabla_j \nabla^-2 - 1/3 delta^K_ij] delta. The other multiplies s_ij t_ji, where t_ij=[nabla_i nabla_j nabla^-2 - 1/3 delta^K_ij](theta-delta), with theta=-(a H dlnD/dlna)^-1 nabla_i v_i. (There are other, observationally equivalent, ways to write the two terms, e.g., using theta-delta instead of s_ij s_ji.) We show how short-range (non-gravitational) non-locality can be included through a controlled series of higher derivative terms, starting with R^2 nabla^2 delta, where R is the scale of non-locality (this term will be a small correction as long as k^2 R^2 is small, where k is the observed wavenumber). We suggest that there will be much more information in future huge redshift surveys in the range of scales where beyond-linear perturbation theory is both necessary and sufficient than in the fully linear regime.Comment: 24 pg., 5 fi

Preliminary evaluation of the use of pharmacological treatment with convicted sexual offenders experiencing high levels of sexual preoccupation, hypersexuality and/or sexual compulsivity

The current study presents the preliminary evaluation of the impact of pharmacological treatment (Selective Serotonin Reuptake Inhibitors and anti-androgens) on hypersexuality, sexual preoccupation and sexual compulsivity. The participant pool comprised 64 convicted UK sexual offenders who had been voluntarily referred for pharmacological treatment to reduce their hypersexual arousal, 51 of whom agreed to take the medication (with a further five individuals on hold or under assessment at the time of data extraction). The preliminary findings were very encouraging; analysis on measures assessing sexual preoccupation, hypersexuality and sexual compulsivity indicated a significant reduction between pre- and post-medication, across both types of medication. Limitations of the current research are discussed