Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces

Current orthopedic implants have functional lifetimes of only 10–15 years due to a variety of reasons including infection, extensive inflammation, and overall poor osseointegration (or a lack of prolonged bonding of the implant to juxtaposed bone). To improve properties of titanium for orthopedic applications, this study anodized and subsequently coated titanium with drugs known to reduce infection (penicillin/streptomycin) and inflammation (dexamethasone) using simple physical adsorption and the deposition of such drugs from simulated body fluid (SBF). Results showed improved drug elution from anodized nanotubular titanium when drugs were coated in the presence of SBF for up to 3 days. For the first time, results also showed that the simple physical adsorption of both penicillin/streptomycin and dexamethasone on anodized nanotubular titanium improved osteoblast numbers after 2 days of culture compared to uncoated unanodized titanium. In addition, results showed that depositing such drugs in SBF on anodized titanium was a more efficient method to promote osteoblast numbers compared to physical adsorption for up to 2 days of culture. In addition, osteoblast numbers increased on anodized titanium coated with drugs in SBF for up to 2 days of culture compared to unanodized titanium. In summary, compared to unanodized titanium, this preliminary study provided unexpected evidence of greater osteoblast numbers on anodized titanium coated with either penicillin/streptomycin or dexamethasone using simple physical adsorption or when coated with SBF; results which suggest the need for further research on anodized titanium orthopedic implants possessing drug-eluting nanotubes

The life and work of Nick Fofonoff

Author Posting. © Sears Foundation for Marine Research, 2005. This article is posted here by permission of Sears Foundation for Marine Research for personal use, not for redistribution. The definitive version was published in Journal of Marine Research 63 (2005): 1-7, doi:10.1357/0022240053693824

Management of difficult cases in female urology and neurourology at the Reed M. Nesbit society meeting festschrift in honor of Edward J. McGuire, MD

This is a panel discussion of seven complex urologic cases in female urology and neurourology. Differences in diagnosis and management are discussed by this international panel of experts. Neurourol. Urodynam. 29:S2–S12, 2010. © 2010 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71363/1/20795_ftp.pd

NASA advanced aeronautics design solar powered remotely piloted vehicle

Environmental problems such as the depletion of the ozone layer and air pollution demand a change in traditional means of propulsion that is sensitive to the ecology. Solar powered propulsion is a favorable alternative that is both ecologically harmless as well as cost effective. Integration of solar energy into designs ranging from futuristic vehicles to heating is beneficial to society. The design and construction of a Multi-Purpose Remotely Piloted Vehicle (MPRPV) seeks to verify the feasibility of utilizing solar propulsion as a primary fuel source. This task has been a year long effort by a group of ten students, divided into five teams, each dealing with different aspects of the design. The aircraft was designed to take-off, climb to the design altitude, fly in a sustained figure-eight flight path, and cruise for approximately one hour. This mission requires flight at Reynolds numbers between 150,000 and 200,000 and demands special considerations in the aerodynamic design in order to achieve flight in this regime. Optimal performance requires a light weight configuration with both structural integrity and maximum power availability. The structure design and choice of solar cells for the propulsion was governed by the weight, efficiency, and cost considerations. The final design is a MPRPV weighting 35 N which cruises 7 m/s at the design altitude of 50 m. The configuration includes a wing composed of balsa and foam NACA 6409 airfoil sections and carbon fiber spars, a tail of similar construction, and a truss structure fuselage. The propulsion system consists of 98 10 percent efficient solar cells donated by Mobil Solar, a NiCad battery for energy storage, and a folding propeller regulated by a lightweight and efficient control system. The airfoils and propeller chosen for the design were research and tested during the design process

Arene C–H activation using Rh(I) catalysts supported by bidentate nitrogen chelates

The Rh(I) complexes [(^(Fl)DAB)Rh(coe)(TFA)] (1) and [(BOZO)Rh(coe)(TFA)] (2) [^(Fl)DAB = N,N-bis-(pentafluorophenyl)-2,3-dimethyl-1,4-diaza-1,3-butadiene, coe = cyclooctene, TFA = trifluoroacetate, BOZO = bis(2-oxazolin-2-yl)] are efficient catalyst precursors for H/D exchange between arenes and DTFA. Catalyst precursor 1 exhibits a TOF of 0.06 s^(−1) at 150 °C for benzene H/D exchange. DFT calculations revealed that H/D exchange through reversible oxidative addition or internal electrophilic substitution of benzene is a viable pathway

The Most Powerful Lenses in the Universe: Quasar Microlensing as a Probe of the Lensing Galaxy

Optical and X-ray observations of strongly gravitationally lensed quasars (especially when four separate images of the quasar are produced) determine not only the amount of matter in the lensing galaxy but also how much is in a smooth component and how much is composed of compact masses (e.g., stars, stellar remnants, primordial black holes, CDM sub-halos, and planets). Future optical surveys will discover hundreds to thousands of quadruply lensed quasars, and sensitive X-ray observations will unambiguously determine the ratio of smooth to clumpy matter at specific locations in the lensing galaxies and calibrate the stellar mass fundamental plane, providing a determination of the stellar $M/L$. A modest observing program with a sensitive, sub-arcsecond X-ray imager, combined with the planned optical observations, can make those determinations for a large number (hundreds) of the lensing galaxies, which will span a redshift range of $\sim$$0.25<z<1.5$Comment: Astro2020 Science White Pape

Resolving the Composite Fe K-alpha Emission Line in the Galactic Black Hole Cygnus X-1 with Chandra

We observed the Galactic black hole Cygnus X-1 with the Chandra High Energy Transmission Grating Spectrometer for 30 kiloseconds on 4 January, 2001. The source was in an intermediate state, with a flux that was approximately twice that commonly observed in its persistent low/hard state. Our best-fit model for the X-ray spectrum includes narrow Gaussian emission line (E = 6.415 +/- 0.007 keV, FWHM = 80 (+28, -19) eV, W = 16 (+3, -2) eV) and broad line (E = 5.82 (+0.06, -0.07) keV, FWHM = 1.9 (+0.5, -0.3) keV, W = 140 (+70, -40) eV) components, and a smeared edge at 7.3 +/- 0.2 keV (tau ~ 1.0). The broad line profile is not as strongly skewed as those observed in some Seyfert galaxies. We interpret these features in terms of an accretion disk with irradiation of the inner disk producing a broad Fe K-alpha emission line and edge, and irradiation of the outer disk producing a narrow Fe K-alpha emission line. The broad line is likely shaped predominantly by Doppler shifts and gravitational effects, and to a lesser degree by Compton scattering due to reflection. We discuss the underlying continuum X-ray spectrum and these line features in the context of diagnosing the accretion flow geometry in Cygnus X-1 and other Galactic black holes.Comment: Accepted for publication in Ap