53 research outputs found
Renal Effects of the Novel Selective Adenosine A1 Receptor Blocker SLV329 in Experimental Liver Cirrhosis in Rats
Liver cirrhosis is often complicated by an impaired renal excretion of water and sodium. Diuretics tend to further deteriorate renal function. It is unknown whether chronic selective adenosine A1 receptor blockade, via inhibition of the hepatorenal reflex and the tubuloglomerular feedback, might exert diuretic and natriuretic effects without a reduction of the glomerular filtration rate. In healthy animals intravenous treatment with the novel A1 receptor antagonist SLV329 resulted in a strong dose-dependent diuretic (up to 3.4-fold) and natriuretic (up to 13.5-fold) effect without affecting creatinine clearance. Male Wistar rats with thioacetamide-induced liver cirrhosis received SLV329, vehicle or furosemide for 12 weeks. The creatinine clearance of cirrhotic animals decreased significantly (−36.5%, p<0.05), especially in those receiving furosemide (−41.9%, p<0.01). SLV329 was able to prevent this decline of creatinine clearance. Mortality was significantly lower in cirrhotic animals treated with SLV329 in comparison to animals treated with furosemide (17% vs. 54%, p<0.05). SLV329 did not relevantly influence the degree of liver fibrosis, kidney histology or expression of hepatic or renal adenosine receptors. In conclusion, chronic treatment with SLV329 prevented the decrease of creatinine clearance in a rat model of liver cirrhosis. Further studies will have to establish whether adenosine A1 receptor antagonists are clinically beneficial at different stages of liver cirrhosis
Idiopathic non-histaminergic acquired angioedema: a case series and discussion of published clinical trials
Ueber die Anwendung des sauren schwefelsauren Kali als Reagens und Aufschluss — Mittel bei der Untersuchung geschwefelter Erze und analoger Verbindungen
Ergebnisse nach chirurgischer Therapie der prähepatischen portalen Hypertension durch Cooley-Shunt
Interprofessionelles Lehrprojekt Ernährungsmedizin: Effekte auf den Lernerfolg von Medizinstudierenden im Praktischen Jahr und im Masterstudiengang Ernährungswissenschaften
How to report multiple outcome metrics in virtual reality simulation
Summary: Background: Virtual reality (VR) simulation is increasingly used in surgical disciplines. Since VR simulators measure multiple outcomes, standardized reporting is needed. Methods: We present an algorithm for combining multiple VR outcomes into dimension summary measures, which are then integrated into a meaningful total score. We reanalyzed the data of two VR studies applying the algorithm. Results: The proposed algorithm was successfully applied to both VR studies. Conclusions: The algorithm contributes to standardized and transparent reporting in VR-related research
How to report multiple outcome metrics in virtual reality simulation
Background
Virtual reality (VR) simulation is increasingly used in surgical disciplines. Since VR simulators measure multiple outcomes, standardized reporting is needed.
Methods
We present an algorithm for combining multiple VR outcomes into dimension summary measures, which are then integrated into a meaningful total score. We reanalyzed the data of two VR studies applying the algorithm.
Results
The proposed algorithm was successfully applied to both VR studies.
Conclusions
The algorithm contributes to standardized and transparent reporting in VR-related research
Langzeitergebnisse, Morbidität und Lebensqualität nach offener Abdomenbehandlung bei allgemeinchirurgischen Patienten: Folgen der "abdominalen Katastrophe"
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