3,133 research outputs found
Alkaloidal content of four Berberis species : structure of berberilaurine, a new bisbenzyltetrahydroisoquinoline
High-resolution UV spectrum of the benzene—N2 van der Waals complex
The rotationally resolved spectrum of the 610 band of the S1 ← S0 electronic transition of the benzene—N2 van der Waals complex has been recorded and 119 transitions assigned. The C6H6·N2 complex, produced in a pulsed molecular beam, was detected by mass-selected two-photon two-colour ionization employing a high-resolution (ΔνUV = 100 MHz, fwhm) pulsed-amplified cw laser for the resonant intermediate excitation. The observed rotational structure is that of a rigid symmetric top with weaker additional rotational transitions most likely arising from the free internal rotation of the N2 in the plane parallel to the benzene ring. The N2 is located parallel to the benzene ring at a distance of 3.50 Å; this decreases by 45 mÅ in the excited electronic state
The JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis
Innate immunity contributes to the pathogenesis of inflammatory bowel disease (IBD). However, the mechanisms of IBD mediated by innate immunity are incompletely understood and there are limited models of spontaneous innate immune colitis to address this question. Here we describe a new robust model of colitis occurring in the absence of adaptive immunity. RAG1-deficient mice expressing TNFAIP3 in intestinal epithelial cells (TRAG mice) spontaneously developed 100% penetrant, early-onset colitis that was limited to the colon and dependent on intestinal microbes but was not transmissible to co-housed littermates. TRAG colitis was associated with increased mucosal numbers of innate lymphoid cells (ILCs) and depletion of ILC prevented colitis in TRAG mice. ILC depletion also therapeutically reversed established colitis in TRAG mice. The colitis in TRAG mice was not prevented by interbreeding to mice lacking group 3 ILC nor by depletion of TNF. Treatment with the JAK inhibitor ruxolitinib ameliorated colitis in TRAG mice. This new model of colitis, with its predictable onset and colon-specific inflammation, will have direct utility in developing a more complete understanding of innate immune mechanisms that can contribute to colitis and in pre-clinical studies for effects of therapeutic agents on innate immune-mediated IBD
Dependence of direct detection signals on the WIMP velocity distribution
The signals expected in WIMP direct detection experiments depend on the
ultra-local dark matter distribution. Observations probe the local density,
circular speed and escape speed, while simulations find velocity distributions
that deviate significantly from the standard Maxwellian distribution. We
calculate the energy, time and direction dependence of the event rate for a
range of velocity distributions motivated by recent observations and
simulations, and also investigate the uncertainty in the determination of WIMP
parameters. The dominant uncertainties are the systematic error in the local
circular speed and whether or not the MW has a high density dark disc. In both
cases there are substantial changes in the mean differential event rate and the
annual modulation signal, and hence exclusion limits and determinations of the
WIMP mass. The uncertainty in the shape of the halo velocity distribution is
less important, however it leads to a 5% systematic error in the WIMP mass. The
detailed direction dependence of the event rate is sensitive to the velocity
distribution. However the numbers of events required to detect anisotropy and
confirm the median recoil direction do not change substantially.Comment: 21 pages, 7 figures, v2 version to appear in JCAP, minor change
Correlated electron emission in laser-induced nonsequence double ionization of Helium
In this paper, we have investigated the correlated electron emission of the
nonsequence double ionization (NSDI) in an intense linearly polarized field.
The theoretical model we employed is the semiclassical rescattering model, the
model atom we used is the helium. We find a significant correlation between
magnitude and direction of the momentum of two emission electrons, and give a
good explanation for this striking phenomenon by observing the classical
collisional trajectories. We argue that this correlation phenomenon is
universal in NSDI process, as revealed by the recent experiment on the argon.Comment: 4 pages, 3 figures, accepted for publication in Phys. Rev.
Monte Carlo simulation of a two-dimensional continuum Coulomb gas
We study the classical two-dimensional Coulomb gas model for thermal vortex
fluctuations in thin superconducting/superfluid films by Monte Carlo simulation
of a grand canonical vortex ensemble defined on a continuum. The
Kosterlitz-Thouless transition is well understood at low vortex density, but at
high vortex density the nature of the phase diagram and of the vortex phase
transition is less clear. From our Monte Carlo data we construct phase diagrams
for the 2D Coulomb gas without any restrictions on the vortex density. For
negative vortex chemical potential (positive vortex core energy) we always find
a Kosterlitz-Thouless transition. Only if the Coulomb interaction is
supplemented with a short-distance repulsion, a first order transition line is
found, above some positive value of the vortex chemical potential.Comment: 10 pages RevTeX, 7 postscript figures included using eps
Monte Carlo calculation of the current-voltage characteristics of a two dimensional lattice Coulomb gas
We have studied the nonlinear current-voltage characteristic of a two
dimensional lattice Coulomb gas by Monte Carlo simulation. We present three
different determinations of the power-law exponent of the nonlinear
current-voltage characteristic, . The determinations rely on
both equilibrium and non-equilibrium simulations. We find good agreement
between the different determinations, and our results also agree closely with
experimental results for Hg-Xe thin film superconductors and for certain single
crystal thin-film high temperature superconductors.Comment: late
Precise Prediction for M_W in the MSSM
We present the currently most accurate evaluation of the W boson mass, M_W,
in the Minimal Supersymmetric Standard Model (MSSM). The full complex phase
dependence at the one-loop level, all available MSSM two-loop corrections as
well as the full Standard Model result have been included. We analyse the
impact of the different sectors of the MSSM at the one-loop level with a
particular emphasis on the effect of the complex phases. We discuss the
prediction for M_W based on all known higher-order contributions in
representative MSSM scenarios. Furthermore we obtain an estimate of the
remaining theoretical uncertainty from unknown higher-order corrections.Comment: 38 pages, 25 figures. Minor corrections, additional reference
A prototype liquid Argon Time Projection Chamber for the study of UV laser multi-photonic ionization
This paper describes the design, realization and operation of a prototype
liquid Argon Time Projection Chamber (LAr TPC) detector dedicated to the
development of a novel online monitoring and calibration system exploiting UV
laser beams. In particular, the system is intended to measure the lifetime of
the primary ionization in LAr, in turn related to the LAr purity level. This
technique could be exploited by present and next generation large mass LAr TPCs
for which monitoring of the performance and calibration plays an important
role. Results from the first measurements are presented together with some
considerations and outlook.Comment: 26 pages, 27 figure
Uptake of gases in bundles of carbon nanotubes
Model calculations are presented which predict whether or not an arbitrary
gas experiences significant absorption within carbon nanotubes and/or bundles
of nanotubes. The potentials used in these calculations assume a conventional
form, based on a sum of two-body interactions with individual carbon atoms; the
latter employ energy and distance parameters which are derived from empirical
combining rules. The results confirm intuitive expectation that small atoms and
molecules are absorbed within both the interstitial channels and the tubes,
while large atoms and molecules are absorbed almost exclusively within the
tubes.Comment: 9 pages, 12 figures, submitted to PRB Newer version (8MAR2K). There
was an error in the old one (23JAN2K). Please download thi
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