Hamid Enayat, Carl W. Ernst, Modern Islamic Political Thought. The Response of the Shī‘ī and Sunnī. Muslims to the Twentieth CenturyAvant-propos de Roy P. Mottahedeh. Londres -New York, I.B. Tauris, 2005 (nouv. éd.), 225 p.Carl W. ErnstRethinking Islam in the Contemporary Wor

Montrer que le mot islam n’a jamais désigné une seule chose et que tous les musulmans ne sont pas pareils, voici les objectifs – certes simples mais toujours importants – du livre de C.W. Ernst. Celui de H. Enayat, publié pour la première fois en 1982, s’y attache implicitement aussi, bien que pour un sujet plus restreint : la pensée politique islamique. S’adressant notamment à des étudiants aux États-Unis, C.W. Ernst veut contredire les idées préconçues, surtout la réduction de l’islam à son..

Aïda Kanafani-Zahar, Liban : le vivre ensemble. Hsoun, 1994-2000

Même dans un pays aussi petit que le Liban, les relations entre différents groupes religieux ne peuvent faire l'objet de généralisations trop rapides. Cette étude d'un microcosme, celui du village bi-confessionnel de Hsoun, montre très bien comment ces relations se construisent localement. A. Kanafani-Zahar y examine le « vivre ensemble » quotidien entre chrétiens et musulmans ou, plus précisément, entre chiites et maronites. Elle décrit comment ce vivre ensemble est activement construit et c..

Anne-Sophie Lamine, La cohabitation des dieux. Pluralité religieuse et laïcité

Juifs, chrétiens, musulmans et adeptes d'autres religions se regroupent de plus en plus souvent dans des associations interreligieuses. L'enjeu de ces rencontres est bien plus grand que celui d'une meilleure connaissance mutuelle. Ce livre, issu d'une thèse en sociologie des religions, explore habilement les différentes dimensions des relations interreligieuses en France – un phénomène en pleine expansion, mais jusqu'ici très peu étudié. L'auteure examine comment le défi de la « reconnaissanc..

Gesundheitsförderung für und mit Jugendlichen und jungen Erwachsenen : wissenschaftliche Erkenntnisse und Empfehlungen für die Praxis

Die Zielgruppe der Jugendlichen und jungen Erwachsenen ist im Kontext der Corona-Pandemie in den Fokus gerückt. Wie wichtig es ist, die Gesundheit der Jugendlichen und jungen Erwachsenen zu fördern, wird durch diese Fokussierung betont. Vor diesem Hintergrund ist es wichtig, die wissenschaftlichen Grundlagen als Basis für wirksame Massnahmen und Interventionen zu aktualisieren. So ist sichergestellt, dass die Grundlage für Programme und Projekte auf dem neuesten Stand ist. Der vorliegende Bericht zeigt, weshalb sich ein Engagement für die Gesundheit von Jugendlichen und jungen Erwachsenen lohnt. Aufbauend auf wissenschaftlichen Erkenntnissen wird gezeigt, warum die Themen Bewegung, Ernährung und psychische Gesundheit wichtige Pfeiler für die Gesundheit im Jugend- und jungen Erwachsenenalter sind. Es werden Interventionen und bewährte Handlungsansätze und Empfehlungen vorgestellt. Autorinnen und Autoren: Kapitel 1 Einleitung und Kapitel 10 Schlussfolgerungen: Dr. phil. Fabienne Amstad Kapitel 2 Lebensphase: Prof. Dr. med. Joan-Carles Suris, Dr. Yara Barrense-Dias Kapitel 3 Grundlagen: Prof. Dr. med. Julia Dratva, Matthias Meyer, dipl. SozÖk, Prof. Dr. phil. Karin Nordström Kapitel 4 Chancengleichheit: lic. phil. Dominik Weber Kapitel 5 Medien: MSc Jael Bernath, Prof. Dr. Daniel Süss Kapitel 6 Bewegung: Prof. Dr. Suzanne Suggs Kapitel 7 Ernährung: Dr. Sophie Bucher Della Torre Kapitel 8 Psychische Gesundheit: Prof. Dr. Frank Wieber, Prof. Dr. Agnes von Wyl, Dr. Annina Zysset Kapitel 9 Zusammenspiel: MSc Ronia Schiftan, MSc Anne-Françoise Wittgenstein Man

H19 Antisense RNA Can Up-Regulate Igf2 Transcription by Activation of a Novel Promoter in Mouse Myoblasts

It was recently shown that a long non-coding RNA (lncRNA), that we named the 91H RNA (i.e. antisense H19 transcript), is overexpressed in human breast tumours and contributes in trans to the expression of the Insulin-like Growth Factor 2 (IGF2) gene on the paternal chromosome. Our preliminary experiments suggested that an H19 antisense transcript having a similar function may also be conserved in the mouse. In the present work, we further characterise the mouse 91H RNA and, using a genetic complementation approach in H19 KO myoblast cells, we show that ectopic expression of the mouse 91H RNA can up-regulate Igf2 expression in trans despite almost complete unmethylation of the Imprinting-Control Region (ICR). We then demonstrate that this activation occurs at the transcriptional level by activation of a previously unknown Igf2 promoter which displays, in mouse tissues, a preferential mesodermic expression (Pm promoter). Finally, our experiments indicate that a large excess of the H19 transcript can counteract 91H-mediated Igf2 activation. Our work contributes, in conjunction with other recent findings, to open new horizons to our understanding of Igf2 gene regulation and functions of the 91H/H19 RNAs in normal and pathological conditions

Toll-Like Receptor 3 (TLR3) Plays a Major Role in the Formation of Rabies Virus Negri Bodies

Human neurons express the innate immune response receptor, Toll-like receptor 3 (TLR3). TLR3 levels are increased in pathological conditions such as brain virus infection. Here, we further investigated the production, cellular localisation, and function of neuronal TLR3 during neuronotropic rabies virus (RABV) infection in human neuronal cells. Following RABV infection, TLR3 is not only present in endosomes, as observed in the absence of infection, but also in detergent-resistant perinuclear inclusion bodies. As well as TLR3, these inclusion bodies contain the viral genome and viral proteins (N and P, but not G). The size and composition of inclusion bodies and the absence of a surrounding membrane, as shown by electron microscopy, suggest they correspond to the previously described Negri Bodies (NBs). NBs are not formed in the absence of TLR3, and TLR3−/− mice—in which brain tissue was less severely infected—had a better survival rate than WT mice. These observations demonstrate that TLR3 is a major molecule involved in the spatial arrangement of RABV–induced NBs and viral replication. This study shows how viruses can exploit cellular proteins and compartmentalisation for their own benefit

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment of variant pathogenicity for multiple cancer syndrome genes. Independent data types currently incorporated in the model for assessing BRCA1 and BRCA2 variants include clinically calibrated prior probability of pathogenicity based on variant location and bioinformatic prediction of variant effect, co-segregation, family cancer history profile, co-occurrence with a pathogenic variant in the same gene, breast tumor pathology, and case-control information. Research and clinical data for multifactorial likelihood analysis were collated for 1,395 BRCA1/2 predominantly intronic and missense variants, enabling classification based on posterior probability of pathogenicity for 734 variants: 447 variants were classified as (likely) benign, and 94 as (likely) pathogenic; and 248 classifications were new or considerably altered relative to ClinVar submissions. Classifications were compared with information not yet included in the likelihood model, and evidence strengths aligned to those recommended for ACMG/AMP classification codes. Altered mRNA splicing or function relative to known nonpathogenic variant controls were moderately to strongly predictive of variant pathogenicity. Variant absence in population datasets provided supporting evidence for variant pathogenicity. These findings have direct relevance for BRCA1 and BRCA2 variant evaluation, and justify the need for gene-specific calibration of evidence types used for variant classification

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat