Effect of Alpha-Particle Irradiation on Brain Glycogen in the Rat

The studies of Klatzo, Miquel, Tobias and Haymaker (1961) have shown that one of the earliest and most sensitive indications of the effects of alpha-particle irradiation on rat bran is the appearance of glycogen granules mainly in the neuroglia of the exposed area of the brain. Periodic acid-Schiff (PAS) positive, alpha-amylase soluble granules were demonstrated within 12 hr after irradiation, preceding by approximately 36 hr the first microscopically detectable vascular permeability disturbances, as shown by the fluorescein labeled serum protein technique. These studies suggested that the injurious effects of alpha-particle energy were on cellular elements primarily, according to the physical properties and distribution of the radiation in the tissue, and that the vascular permeability disturbances played a secondary role in pathogenesis. The purpose of this study was to correlate the histochemical observations on glycogen with a quantitative assessment of the glycogen in the irradiated brain tissue. It is felt that such a study may contribute to the understanding of radiation injury at the molecular level. A practical aspect of this problem is that the information on biological radiation effects due to accelerated particles from the cyclotron source, is employed in this study, is applicable to radiation from cosmic particles both in free space and entrapped in the Van Allen belts

Neurological problems in the world in 1953

xi, 1115 p.; 25 cm

Tissue culture of the pituitary.

In regard to terminology, Hypophysis cerebri and Glandula pituitaria cerebri are used in this thesis without distinction. Basically, it is difficult to decide which term is preferable. The term hypophysis has been considered as the more correct since it denotes only an anatomical position. Even so, the word has its disadvantages, for it means "to growunder"; and since two of the three parts of the hypophysis cerebri grow upwards, its use is obviously inexact. [...

Bing's local diagnosis in neurological diseases

xiii+600hlm.;25c