Tenement House Conditions in Five Rhode Island Cities

George H. Webb, Commissioner. Carol Aronovici, Special Agent. Rhode Island Bureau of Industrial Statistics. Part I of the Annual Report for 1910. A report commissioned by the Rhode Island Bureau of Industrial Statistics conducted in cooperation with the Rhode Island Bureau of Social Research, an agency of the Union for Christian Work, which examined the tenement housing conditions found in Providence, Pawtucket, Central Falls, Woonsocket, and Newport, RI.https://digitalcommons.providence.edu/ri_history/1017/thumbnail.jp

Human-automation collaboration in manufacturing: identifying key implementation factors

Human-automation collaboration refers to the concept of human operators and intelligent automation working together interactively within the same workspace without conventional physical separation. This concept has commanded significant attention in manufacturing because of the potential applications, such as the installation of large sub-assemblies. However, the key human factors relevant to human-automation collaboration have not yet been fully investigated. To maximise effective implementation and reduce development costs for future projects these factors need to be examined. In this paper, a collection of human factors likely to influence human-automation collaboration are identified from current literature. To test the validity of these and explore further factors associated with implementation success, different types of production processes in terms of stage of maturity are being explored via industrial case studies from the project’s stakeholders. Data was collected through a series of semi-structured interviews with shop floor operators, engineers, system designers and management personnel

The development of a Human Factors Readiness Level tool for implementing industrial human-robot collaboration

The concept of industrial human-robot collaboration (HRC) is becoming increasingly attractive as a means for enhancing manufacturing productivity and product. However, due to traditional preventive health and safety standards, there have been few operational examples of true HRC, so it has not been possible to explore the organisational human factors that need to be considered by manufacturing organisations to realise the benefits of industrial HRC until recently. Charalambous, Fletcher and Webb (2015) made the first attempt to identify the key organisational human factors for the successful implementation of industrial HRC through an industrial exploratory case study. This work enabled (i) development of a theoretical framework of key organisational human factors relevant to industrial HRC and (ii) identification of these factors as enablers or barriers. Although identifying the key organisational human factors (HF) was an important step, it presented a crucial question: when should practitioners involved in HRC design and implementation consider these factors? New industrial processes are typically designed and implemented using a maturity or readiness evaluation system, but these do not incorporate of or link to any formal considerations of HF. The aim of this paper is to expand on the previous findings and link the key human factors in the theoretical framework directly to a recognised industrial maturity readiness level system to develop a new Human Factors Readiness Level (HFRL) tool for system design practitioners to optimise successful implementation of industrial HRC

Correspondences - 1904, January 20 - George Milton Webb

This is a handwritten letter from Madge\u27s grandfather George Milton Webb, writing to keep in touch. Letter is written on paper with a heading Mutual Life Insurance Association of Georgia and the heading gives details about the company. Handwrittenhttps://digitalcommons.gardner-webb.edu/fay-webb-gardner-madge-webb-riley/1002/thumbnail.jp

The Resources of the Cumberland Plateau as Exemplified by Cumberland County, Tennessee: A Geographic Analysis

The Problem and Purpose of the Study: Possibly no other area in Anglo-America shows better the relation between man and a restrictive environment than the Cumberland Plateau. Certainly no other presents a more interesting social and geographic picture: here dwells [sic] some of the best racial stock in the United States (much of it pre-Revolutionary) and at the same time the largest number of illiterate and poverty-stricken people in the nation. What they are, no doubt, is more a matter of natural environment than of anything else. . . . The above statement is the introduction by White and Foscue to their discussion of the Cumberland Plateau. The basis for this dissertation is embodied within the ideas expressed in this statement, for herein lies the heart of a problem: the prosperity of a people has been limited by a restrictive environment

Understanding Your Water Quality Analysis

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Weep Not for Me: A Sacred Song

When the spark of life is waningWeep not for meWhen the languid eye is stealingWeep not for meWhen the feeble pulse is ceasingStart not at its swift decreasing\u27Tis the fettered soul\u27s releasing Weep weep not for me. When the pangs of death assail me,Weep not for me. Christ is mine he cannot fail me,Weep not for me.Yes, though sin and doubt endeavour From his love my soul to sever,Jesus is my strength foreverWeep weep not for me

Splicing factor 3B subunit 1 interacts with HIV Tat and plays a role in viral transcription and reactivation from latency

ABSTRACT The main obstacle to an HIV cure is the transcriptionally inert proviruses that persist in resting CD4 T cells and other reservoirs. None of the current approaches has significantly reduced the size of the viral reservoir. Hence, alternative approaches, such as permanent blocking of viral transcription, to achieve a sustained remission, need urgent attention. To identify cellular factors that may be important for this approach, we sought for host targets that when altered could block HIV transcription and reactivation. Here, we identified splicing factor 3B subunit 1 (SF3B1) as a critical HIV dependency factor required for viral replication. SF3B1 is a splicing factor involved in directing chromatin and nascent gene transcripts to appropriate splice sites. Inhibitors of SF3B1 are currently in development for cancer and have been found to be nontoxic to normal cells compared to malignant cells. Knockdown of SF3B1 abrogated HIV replication in all cell types tested. SF3B1 interacted with viral protein Tat in vitro and in vivo. Genetic or pharmacologic inhibition of SF3B1 prevented Tat-mediated HIV transcription and RNA polymerase II association with the HIV promoter. In addition, an inhibitor of SF3B1 prevented HIV reactivation from latency irrespective of the latency-reversing agent used. The data show that SF3B1 is involved in viral transcription and reactivation from latency and may serve as a therapeutic target in the HIV cure efforts. IMPORTANCE The reason why HIV cannot be cured by current therapy is because of viral persistence in resting T cells. One approach to permanent HIV remission that has received less attention is the so-called “block and lock” approach. The idea behind this approach is that the virus could be permanently disabled in patients if viral genome or surrounding chromatin could be altered to silence the virus, thus enabling patients to stop therapy. In this work, we have identified splicing factor 3B subunit 1 (SF3B1) as a potential target for this approach. SF3B1 interacts with the viral protein Tat, which is critical for viral transcription. Inhibition of SF3B1 prevents HIV transcription and reactivation from latency. Since there are preclinical inhibitors for this protein, our findings could pave the way to silence HIV transcription, potentially leading to prolonged or permanent remission

Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator

Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein. Intracellular c-di-GMP levels in turn regulate bacterial motility, virulence and biofilm formation. We report the first structure of a tandem DGC–PDE fragment, in which the catalytic domains are shown to be active. Two phosphodiesterase states are distinguished by active site formation. The structures, in the presence or absence of c-di-GMP, suggest that dimerisation and binding pocket formation are linked, with dimerisation being required for catalytic activity. An understanding of PDE activation is important, as biofilm dispersal via c-di-GMP hydrolysis has therapeutic effects on chronic infections

“It becomes more of an abstract idea, this privacy”—Informing the design for communal privacy experiences in smart homes

In spite of research recognizing the home as a shared space and privacy as inherently social, privacy in smart homes has mainly been researched from an individual angle. Sometimes contrasting and comparing perspectives of multiple individuals, research has rarely focused on how household members might use devices communally to achieve common privacy goals. An investigation of communal use of smart home devices and its relationship with privacy in the home is lacking. The paper presents a grounded analysis based on a synergistic relationship between an ethnomethodologically-informed (EM-informed) study and a grounded theory (GT) approach. The study focuses on household members’ interactions to show that household members’ ability to coordinate the everyday use of their devices depends on appropriate conceptualizations of roles, rules, and privacy that are fundamentally different from those embodied by off-the-shelf products. Privacy is rarely an explicit, actionable, and practical consideration among household members, but rather a consideration wrapped up in everyday concerns. Roles and rules are not used to create social order, but to account for it. To sensitize to this everyday perspective and to reconcile privacy as wrapped up in everyday concerns with the design of smart home systems, the paper presents the social organization of communal use as a descriptive framework. The framework is descriptive in capturing how households navigate the ‘murky waters’ of communal use in practice, where prior research highlighted seemingly irreconcilable differences in interest, attitude, and aptitude between multiple individuals and with other stakeholders. Discussing how households’ use of roles, rules, and privacy in-practice differed from what off-the-shelf products afforded, the framework highlights critical challenges and opportunities for the design of communal privacy experiences