Municipal Government Support of the Social Economy Sector

The research scope includes municipal governments in the Canadian provinces of British Columbia, Alberta, Saskatchewan, Manitoba and Ontario (northwestern portion of the province).This report is based on research conducted by the BC-Alberta Social Economy Research Alliance (BALTA) in association with the Saskatchewan/Manitoba/Northwestern Ontario node of the Canadian Social Economy Research Partnerships. It describes and analyzes the current state of municipal government involvement in and support of the social economy sector. The social economy sector can offer innovative responses to the complex social and economic challenges that municipalities face. As the level of government closest to people and communities, municipal governments can play a lead role in supporting the social economy sector. This research into the role of municipal government in the social economy identifies models of engagement and means for strengthening this role.BC-Alberta Social Economy Research Alliance (BALTA) ; Linking, Learning, Leveraging Project - Northern Ontario, Manitoba, and Saskatchewan Regional Node of the Social Economy Suite ; Social Sciences and Humanities Research Council of Canada (SSHRC) ; City of Edmonto

CERVICAL SPINAL CORD INJURY AND UPPER LIMB ROBOTIC THERAPY

Abstract. A major debilitating factor of sustaining a cervical level spinal cord injury is the loss of independence in completing activities of daily living as a result of impaired upper limb function. Early intervention has been hypothesised to preserve upper limb function in this population and enhance capacity to perform functional tasks. The use of robotics as an upper limb therapy modality is increasing in the neurorehabilitation field, however there is limited evidence to support their use in the cervical spinal cord injury population. Despite this, occupational therapists are using them as part of a therapy program. Aim: This study aimed to explore the upper limb outcomes of using a computer assisted robotic device in acute therapy for people who have sustained a cervical spinal cord injury. Methods: A single case pre-post study design was performed with one middle aged male who had who was an inpatient at a public metropolitan hospital in Australia. They undertook a three week therapy program using the Diego by Tyromotion in conjunction with standard occupational therapy interventions. Range of motion, muscular strength, pain, fatigue the Spinal Cord Independence Measure, and the Canadian Occupational Performance Measure were used as outcome measures. Results: Increases were seen in range of motion and muscular strength and functional status; objective and subjectively. Conclusion: Preliminary findings suggest that the Diego may be a useful tool for improving upper limb outcomes when combined with occupational therapy in this population, however greater research and participants are required for definitive data

ELF3 controls thermoresponsive growth in Arabidopsis

Plant development is highly responsive to ambient temperature, and this trait has been linked to the ability of plants to adapt to climate change [1]. The mechanisms by which natural populations modulate their thermoresponsiveness are not known [2]. To address this, we surveyed Arabidopsis accessions for variation in thermal responsiveness of elongation growth and mapped the corresponding loci. We find that the transcriptional regulator EARLY FLOWERING3 (ELF3) controls elongation growth in response to temperature. Through a combination of modeling and experiments, we show that high temperature relieves the gating of growth at night, highlighting the importance of temperature-dependent repressors of growth. ELF3 gating of transcriptional targets responds rapidly and reversibly to changes in temperature. We show that the binding of ELF3 to target promoters is temperature dependent, suggesting a mechanism where temperature directly controls ELF3 activity

The AddAB helicase–nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain

The oligomeric state of Superfamily I DNA helicases is the subject of considerable and ongoing debate. While models based on crystal structures imply that a single helicase core domain is sufficient for DNA unwinding activity, biochemical data from several related enzymes suggest that a higher order oligomeric species is required. In this work we characterize the helicase activity of the AddAB helicase–nuclease, which is involved in the repair of double-stranded DNA breaks in Bacillus subtilis. We show that the enzyme is functional as a heterodimer of the AddA and AddB subunits, that it is a rapid and processive DNA helicase, and that it catalyses DNA unwinding using one single-stranded DNA motor of 3′→5′ polarity located in the AddA subunit. The AddB subunit contains a second putative ATP-binding pocket, but this does not contribute to the observed helicase activity and may instead be involved in the recognition of recombination hotspot sequences

On Free-Electron Laser Growing Modes and their Bandwidth

Free-electron lasers play an increasing role in science, from generating unique femtosecond X- ray pulses for single short recording of the protein structures to amplifying feeble interactions in advanced cooling systems for high-energy hadron colliders. While modern Free-electron laser codes can describe their amplification mechanism, a deep analytical understanding of the mechanism is of extreme importance for a number of applications. Mode competition, their growth rates and amplification bandwidth are among the most important parameters of a free-electron laser. A dispersion relation, which defines these important characteristics, can be solved analytically only for a very few simple cases. In this letter we show that for a typical bell-shape energy distribution in electron beam there is no more that one growing mode. We also derive an analytical expression which determines the bandwidth of the free-electron laser.Comment: 4 pages, submitted to PR

The visual vaccine debate on Twitter: A social network analysis

Pro- and anti-vaccination users use social media outlets, such as Twitter, to join conversations about vaccines, disseminate information or misinformation about immunization, and advocate in favour or against vaccinations. These users not only share textual content, but also images to emphasise their messages and influence their audiences. Though previous studies investigated the content of vaccine images, there is little research on how these visuals are distributed in digital environments. Therefore, this study explored how images related to vaccination are shared on Twitter to gain insight into the communities and networks formed around their dissemination. Moreover, this research also investigated who influences the distribution of vaccine images, and could be potential gatekeepers of vaccination information. We conducted a social network analysis on samples of tweets with images collected in June, September and October 2016. In each dataset, pro- and anti-vaccination users formed two polarised networks that hardly interacted with each other, and disseminated images among their members differently. The anti-vaccination users frequently retweeted each other, strengthening their relationships, making the information redundant within their community, and confirming their beliefs against immunisation. The pro-vaccine users, instead, formed a fragmented network, with loose but strategic connections that facilitated networking and the distribution of new vaccine information. Moreover, while the pro-vaccine gatekeepers were non-governmental organisations or health professionals, the anti-vaccine ones were activists and/or parents. Activists and parents could potentially be considered as alternative but trustworthy sources of information enabling them to disseminate misinformation about vaccinations

Repetitive Stimulation of the Pituitary with Growth-Hormone-Releasing Hormone Alters the Proportion of 22 and 20 Kilodalton Human-Growth Hormone Released

Background/Aims. 20 Kilodalton-hGH (20 K-hGH) is the second most abundant pituitary GH variant after 22 K-hGH. In the steady state the proportion of 20 : 22 K-hGH appears constant; does this proportion change with repetitive somatotroph stimulation? Methods. Forty adult males were randomised to receive a GHRH(1–29)NH2 bolus (0.5 μg/kg (n = 20) or 1.0 μg/kg (n = 20)), preceded or followed by a saline bolus, 1 week apart. Four to six weeks later, 10 subjects received 0.5 μg/kg GHRH(1–29)NH2 at 0, 60, 120, and 180 minutes. Clearance rate of 22 and 20 K-hGH was measured in 10 subjects. Results. Total amount/proportion of 22 K-hGH/20 K-hGH secreted was similar for both GHRH(1–29)NH2 doses. Repetitive stimulation reduced the amount of 22 K-hGH released whereas the amount of 20 K-hGH did not change significantly leading to an increase in the proportion of 20 K-hGH (P = .05). Half-life of 20 and 22 K-hGH were not significantly different (P = .55). Conclusions. Repetitive stimulation of the somatotroph may alter the proportion of GH variant released

How close is the dose? Manipulation of 10 mg hydrocortisone tablets to provide appropriate doses to children

This study explores the methodology advised by healthcare professionals and the methods used by parents/carers to identify whether there is a best practice method for manipulation of 10 mg hydrocortisone tablets to provide an accurate dose to children. Bespoke surveys were used to identify methods recommended and used in manipulation of tablets. Hydrocortisone tablets were manipulated to provide a specified dose by both naïve participants and parents/carers. The accuracy of manipulation was assessed using HPLC analysis. Competed surveys were received from 159 parent/carers reporting doses that ranged from 0.25 to 15 mg. Parents/carers most commonly reported splitting the tablet and administering the solid fraction; however more than 30% of those reporting physically splitting tablets were preparing doses that were not simply halving or quartering tablets. In a naïve population the dose accuracy, defined as percent of doses within 20% of the theoretical dose ranged from 57 to 58% depending on the tablet brand and the method of manipulation used. Almost three-quarters (74.1%) of parent/carers (n = 27) were able to produce a dose within 20% of the theoretical value and the most accurate method was to split tablets and administer the solid fraction. This study shows that a lack of age-appropriate medicines results in children being at risk of sub-optimal dosing