Learning to Segment Breast Biopsy Whole Slide Images

We trained and applied an encoder-decoder model to semantically segment breast biopsy images into biologically meaningful tissue labels. Since conventional encoder-decoder networks cannot be applied directly on large biopsy images and the different sized structures in biopsies present novel challenges, we propose four modifications: (1) an input-aware encoding block to compensate for information loss, (2) a new dense connection pattern between encoder and decoder, (3) dense and sparse decoders to combine multi-level features, (4) a multi-resolution network that fuses the results of encoder-decoders run on different resolutions. Our model outperforms a feature-based approach and conventional encoder-decoders from the literature. We use semantic segmentations produced with our model in an automated diagnosis task and obtain higher accuracies than a baseline approach that employs an SVM for feature-based segmentation, both using the same segmentation-based diagnostic features.Comment: Added more WSI images in appendi

Opportunity, Community, and Teen Pregnancy in an Appalachian State

Teen pregnancy has become an issue that educators and public policy makers are obliged to treat as a serious problem. Too often, explanations of teen pregnancy have included uncritical use of the notion of adolescents at risk. Recently, however, attention has been given to structurally-determined contextual factors in explaining teen pregnancy. Such contextual factors include economic and educational opportunities and costs, as well as chances for valued participation in socially and culturally stable communities. This interest in contextual factors parallels a development in the literature on high school dropouts. A data set previously employed to study variability in drop-out rates among school districts in the Appalachian state of West Virginia was used. Results show that teen pregnancy can be explained in much the same way as dropping out. Explanation in terms of contextual factors helps to avoid the victim-blaming accounts sometimes associated with the notion of teenagers at risk. It also suggests that conventional pregnancy prevention programs may be constrained by these same contextual factors in ways that are not typically appreciated

Diabetes-related quality of life and the demands and burdens of diabetes care among emerging adults with type 1 diabetes in the year after high school graduation

The roles of glycemic control, diabetes management, diabetes care responsibility, living independently of parents, and time since high school graduation in predicting diabetes-related quality of life (DQOL) were examined in 184 emerging adults with type 1 diabetes. Data were collected at graduation and 1 year later. Analyses controlling for selected covariates were completed using generalized linear mixed models. Better diabetes management was associated with more positive responses on all four dimensions of DQOL. Impact and worry of DQOL were greater in the presence of depressive symptoms, and life satisfaction was lower. DQOL life satisfaction was lower in those living independently of parents. Young women reported poorer diabetes-related health status than did young men. Time since graduation was not linked to DQOL. Further research is needed on ways to improve DQOL in conjunction with diabetes management and on ways that families can support DQOL when youth live independently

The Ursinus Weekly, March 20, 1969

Board appoints Gold new Weekly editor • Campus Chest to support Melmark Home and Biafra • College names Alumni Director • USGA discusses drinking; Punishment system needed • College counselors Admissions Center offer students aid • Editors\u27 farewell • Letters to the editor • Conscription not the answer; Voluntary service best solution • Miss Cope enthusiastic about Ursinus challenge • From the Hofstra Chronicle • USGA notes • Womens Club plans annual card party • Emig, Novak lead USGA in new council plan • UC student recalls trials, joys of European travel • YM-YWCA officers emphasize civic aid • $500,000 grant for science building awarded to Ursinus • New building to house administrative offices • Williamson and Davis head travel courses • Batsmen begin practice, JV tennis inaugurated • Athletes named for track awards • Dennis recalls his 1930 southern trip • Schwenkler leads UC in swimming finals • Gillespie makes all area squad • Arts Festival \u2769: A reviewhttps://digitalcommons.ursinus.edu/weekly/1172/thumbnail.jp

Public Perception of Pesticide Exposure in Vermont

Introduction: A pesticide is any substance intended for preventing, destroying, repelling, or mitigating any pest.1 The public generally believes that insects, diseases, and other pests need to be controlled but is also becoming concerned about the impact of pesticides on their health and the local ecosystem. Pesticide exposure occurs with public and private use. Studies indicate consumers have diverse levels of awareness, knowledge, and attitudes regarding pesticide use and health risks.2 The goal of this project is to identify levels of awareness, knowledge, and attitudes toward pesticide usage in Vermont to help State agencies focus public awareness and education.https://scholarworks.uvm.edu/comphp_gallery/1217/thumbnail.jp

The Ursinus Weekly, February 20, 1969

Excavation begun on lab facilities • Byerly discusses U.C. status for Phi Beta Kappa • Emig turns back Sayare challenge; Novak, Rozycka win in close V.P. contests • SFARC to conduct student drinking poll • Parking regulations • UC Arts Festival opens on March 7 • Only 125 attend winter IF dance • In memoriam • Kitchen experiment • On applied pressure • Letters to the editor • Forum review: Man-sculpture relationship born of African creations\u27 animism • Editorial: Arts weekend, March 7-9 • St. Andrews Society grants awards for study in Scotland • SFARC considers alcohol, arrangement of rules • U.C. holds bleed-in • Ursinus offers graduate course • Sirens seek Lorelei dates • Print Club sponsors campus print exhibit • Bears fall to Mules after Hopkins win • Hofmaster lone victor in Delaware mauling • Gillespie takes luncheon award • Dickinson studies alternatives to college fraternity system • Contemplationshttps://digitalcommons.ursinus.edu/weekly/1170/thumbnail.jp

The Relationship of Worry About Hypoglycemia With Diabetes-specific and Typical Youth Behavior Among Emerging Adults With Type 1 Diabetes

PURPOSE: Little is known about the relationship of worry about hypoglycemia with diabetes-specific and typical youth behaviors among emerging adults with type 1 diabetes. This study's purpose was to examine the relationship among worry about hypoglycemia, diabetes management, and glycemic control within the context of alcohol use, hypoglycemia-related weight control behaviors, depressive symptoms, and impulse control among emerging adults with type 1 diabetes. RESEARCH DESIGN AND METHODS: The sample was 181 emerging adults with type 1 diabetes who were part of a larger study. Path analysis was used to test associations among worry about hypoglycemia, diabetes management, hypoglycemia-related weight control behaviors (WCB), alcohol use, impulse control, depressive symptoms, and glycemic control. RESULTS: Path model fit and modification indices suggested that a feedback loop between worry about hypoglycemia and diabetes management should be incorporated into the original model. Youth with fewer depressive symptoms reported fewer hypoglycemia-related WCB and less worry about hypoglycemia; those with higher impulse control had less alcohol use and better diabetes management; those with lower alcohol use had more worry about hypoglycemia; and better glycemic control was associated with better diabetes management. CONCLUSIONS: Health care professionals need to understand how multiple factors related to worry about hypoglycemia and diabetes management interact in emerging adults. In the context of depressive symptoms, impulse control, alcohol use, and hypoglycemia-related WCB, the path model results suggest several potential avenues for intervening to improve glycemic control in emerging adults

Comparison of DC and RF for lesioning white and grey matter

The morphology of brain lesions produced by anodal direct current and by radio frequency current was compared. The lesions were placed within or adjacent to number of myelinated fiber tracts of the forebrain and brain stem using a range of common current parameters. It was found that with the parameters used anodal current was relatively ineffective for destroying fiber tracts while radio frequency was equally effective for fiber tracts and cellular areas. Thus, differential applicabilities of these two lesion methods are indicated. Additional observations were made on the effect of cathode location upon the shape of anodal direct current lesions. There was a tendency for the anodal lesion to be drawn in the direction of the cathode but the effect was small and inconsistent and therefore its usefulness for controlling the shapes of anodal lesions seems minimal.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22350/1/0000796.pd