Effects of the rACC on the other six network regions suggested by the multivariate VAR analysis.

<p>Average path coefficient values (mean±sem) describing the effects of the left rACC on the other six network regions based on the analysis illustrated in Fig. 3. The results for each of the six experimental runs are shown in red for the experimental group (EG) and in blue for the control group (CG).</p

Trends in the rACC and amygdala effects according to the multivariate SVAR analyses for three ROIs.

<p>The table contains linear trend <i>t</i>-statistics for the SVAR path coefficients across the neurofeedback runs (RE…R3) with the corresponding group <i>P</i>-values. Each data row corresponds to a subplot in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079184#pone-0079184-g007" target="_blank">Fig. 7</a>. An empty cell means an absence of the corresponding interaction from a model. Notations are the same as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079184#pone-0079184-g007" target="_blank">Fig. 7</a>.</p>*<p>indicate significant effect.</p

Interactions suggested by the multivariate SVAR analyses for seven ROIs.

<p>(A) Results of the multivariate first-order structural vector autoregression (SVAR) analysis for the network of seven ROIs using a star model for instantaneous effects of the left rACC (Fig. 5A). (B) Results of a similar SVAR analysis using a star model for instantaneous effects of the left amygdala. For the experimental group (EG), average path coefficients (mean±sem) for the instantaneous effects are depicted in magenta and denoted EG₀, and those for the lagged effects are depicted in red and denoted EG₁. For the control group (CG), average path coefficients for the instantaneous effects are shown in cyan and denoted CG₀, and those for the lagged effects are shown in blue and denoted CG₁.</p

Individual participant FERT results

Individual participant FERT results showing percentage misclassification of other face emotions as sad. Shaded cells represent no data available. This data was used to generate Figure 2

Interactions suggested by the multivariate SVAR analyses for three ROIs.

<p>Results of the multivariate SVAR analyses for the system of three ROIs – the left rACC, the left amygdala, and the right DMPFC – with the models for instantaneous effects depicted in Fig. 5 B,C. (A) Effects that are common to both Model I (Fig. 5B) and Model II (Fig. 5C). (B) Interactions between the left rACC and the left amygdala in the SVAR analysis with Model I (Fig. 5B). (C) Interactions between the left rACC and the left amygdala in the SVAR analysis with Model II (Fig. 5C). Notations are the same as in Fig. 6.</p

MDD individual participant HAM-D scores

MDD individual participant HAM-D scores taken at test visit 1 (baseline) and test visit 3 (final). This data was used to generate Figure 1

Individual participant EREC data

Individual participant EREC data showing number of negative and positive self-referent words falsely recalled for the HC and MDD groups across the 3 visits. Shaded cells represent no data available. This data was used to generate Figure 4

Individual participant mood scores

Individual participant mood scores. This data was used to generate Table 2

Trends in the rACC effects on the other six network regions according to the multivariate VAR analysis.

<p>The table contains linear trend <i>t</i>-statistics for the VAR path coefficients across the neurofeedback runs (RE…R3) with the corresponding group <i>P</i>-values. Each data row corresponds to a subplot in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079184#pone-0079184-g004" target="_blank">Fig. 4</a>. Notations are the same as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079184#pone-0079184-g004" target="_blank">Fig. 4</a>.</p>*<p>indicate significant effect.</p

Trends in the rACC and amygdala effects on the other network regions according to the multivariate SVAR analyses for seven ROIs.

<p>The table contains linear trend <i>t</i>-statistics for the SVAR path coefficients across the six experimental runs (RE…TR) with the corresponding group <i>P</i>-values. Each data row corresponds to a subplot in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079184#pone-0079184-g006" target="_blank">Fig. 6</a>. Notations are the same as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079184#pone-0079184-g006" target="_blank">Fig. 6</a>.</p>*<p>indicate significant effect.</p