239 research outputs found
Relationship Between Teachers\u27 Estimates of Students\u27 Mental Ability and the Students\u27 Intelligence Quotients
In many schools today the students cover material as rapidly as the teacher thinks the student\u27s ability will allow. Grades are usually given on the basis of material covered in relation to the ability of the student. In many school systems, especially smaller and financially poor systems, little or no mental testing is carried on. In such cases, the teacher must base her estimates of mental ability on observed behavior. It is the belief of the writer that in a number of cases the teacher may base her estimates on traits other than those which display general intelligence, such as personality and general appearance. In a study of 1,558 elementary school children Miller found that most of the children who were found to be just average in mentality in all language tests, seemed to be overestimated on account of their pleasantness and hard work. Many children regarded as dull but found to be average in mentality were underestimated because of shyness
Geometric shape of invariant manifolds for a class of stochastic partial differential equations
Invariant manifolds play an important role in the study of the qualitative
dynamical behaviors for nonlinear stochastic partial differential equations.
However, the geometric shape of these manifolds is largely unclear. The purpose
of the present paper is to try to describe the geometric shape of invariant
manifolds for a class of stochastic partial differential equations with
multiplicative white noises. The local geometric shape of invariant manifolds
is approximated, which holds with significant likelihood. Furthermore, the
result is compared with that for the corresponding deterministic partial
differential equations
Pushmataha Forest Habitat Research Area
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction.
The mouse fetal and adult hearts express two adenine nucleotide translocator (ANT) isoform genes. The predominant isoform is the heart-muscle-brain ANT-isoform gene 1 (Ant1) while the other is the systemic Ant2 gene. Genetic inactivation of the Ant1 gene does not impair fetal development but results in hypertrophic cardiomyopathy in postnatal mice. Using a knockin X-linked Ant2 allele in which exons 3 and 4 are flanked by loxP sites combined in males with a protamine 1 promoter driven Cre recombinase we created females heterozygous for a null Ant2 allele. Crossing the heterozygous females with the Ant2(fl), PrmCre(+) males resulted in male and female ANT2-null embryos. These fetuses proved to be embryonic lethal by day E14.5 in association with cardiac developmental failure, immature cardiomyocytes having swollen mitochondria, cardiomyocyte hyperproliferation, and cardiac failure due to hypertrabeculation/noncompaction. ANTs have two main functions, mitochondrial-cytosol ATP/ADP exchange and modulation of the mitochondrial permeability transition pore (mtPTP). Previous studies imply that ANT2 biases the mtPTP toward closed while ANT1 biases the mtPTP toward open. It has been reported that immature cardiomyocytes have a constitutively opened mtPTP, the closure of which signals the maturation of cardiomyocytes. Therefore, we hypothesize that the developmental toxicity of the Ant2 null mutation may be the result of biasing the cardiomyocyte mtPTP to remain open thus impairing cardiomyocyte maturation and resulting in cardiomyocyte hyperproliferation and failure of trabecular maturation. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi
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Testicular degeneration in Bclw-deficient mice
To identify genes required for mammalian spermatogenesis, we screened lines of mutant mice created using a retroviral gene-trap system for male infertility. Homozygous ROSA41 male mice exhibit sterility associated with progressive testicular degeneration. Germ-cell defects are first observed at 19 days post-natal (p19). Spermatogenesis is blocked during late spermiogenesis in young adults. Gradual depletion of all stages of germ cells results in a Sertoli-cell-only phenotype by approximately six months of age. Subsequently, almost all Sertoli cells are lost from the seminiferous tubules and the Leydig cell population is reduced. Molecular analysis indicates that the gene mutated is Bclw, a death-protecting member of the Bcl2 family. The mutant allele of Bclw in ROSA41 does not produce a Bclw polypeptide. Expression of Bclw in the testis appears to be restricted to elongating spermatids and Sertoli cells. Potential roles for Bclw in testicular function are discussed
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Occupation and local times for skew Brownian motion with applications to dispersion across an interface
Advective skew dispersion is a natural Markov process defined ned
by a di ffusion with drift across an interface of jump discontinuity in
a piecewise constant diff usion coeffcient. In the absence of drift this
process may be represented as a function of -skew Brownian motion
for a uniquely determined value of = ; see Ramirez, Thomann,
Waymire, Haggerty and Wood (2006). In the present paper the analysis is extended to the case of non-zero drift. A determination of the (joint) distributions of key functionals of standard skew Brownian motion together with some associated probabilistic semigroup and local time theory is given for these purposes. An application to
the dispersion of a solute concentration across an interface is provided that explains certain symmetries and asymmetries in recently
reported laboratory experiments conducted at Lawrence-Livermore
Berkeley Labs by Berkowitz, Cortis, Dror and Scher (2009).Keywords: stochastic order, occupation time, Skew Brownian motion, local time, first passage time, advection-diffusion, elastic skew Brownian motionKeywords: stochastic order, occupation time, Skew Brownian motion, local time, first passage time, advection-diffusion, elastic skew Brownian motio
A stochastic approach to the solution of magnetohydrodynamic equations
The construction of stochastic solutions is a powerful method to obtain
localized solutions in configuration or Fourier space and for parallel
computation with domain decomposition. Here a stochastic solution is obtained
for the magnetohydrodynamics equations. Some details are given concerning the
numerical implementation of the solution which is illustrated by an example of
generation of long-range magnetic fields by a velocity source.Comment: 21 pages Latex, 5 figure
Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer
BACKGROUND: Recent evidence suggests that bone-related parameters are the main prognostic factors for overall survival in advanced prostate cancer (PCa), with elevated circulating levels of alkaline phosphatase (ALP) thought to reflect the dysregulated bone formation accompanying distant metastases. We have identified that PCa cells express ALPL, the gene that encodes for tissue nonspecific ALP, and hypothesised that tumour-derived ALPL may contribute to disease progression. METHODS: Functional effects of ALPL inhibition were investigated in metastatic PCa cell lines. ALPL gene expression was analysed from published PCa data sets, and correlated with disease-free survival and metastasis. RESULTS: ALPL expression was increased in PCa cells from metastatic sites. A reduction in tumour-derived ALPL expression or ALP activity increased cell death, mesenchymal-to-epithelial transition and reduced migration. Alkaline phosphatase activity was decreased by the EMT repressor Snail. In men with PCa, tumour-derived ALPL correlated with EMT markers, and high ALPL expression was associated with a significant reduction in disease-free survival. CONCLUSIONS: Our studies reveal the function of tumour-derived ALPL in regulating cell death and epithelial plasticity, and demonstrate a strong association between ALPL expression in PCa cells and metastasis or disease-free survival, thus identifying tumour-derived ALPL as a major contributor to the pathogenesis of PCa progression.British Journal of Cancer advance online publication, 22 December 2016; doi:10.1038/bjc.2016.402 www.bjcancer.com
Using prescribed fire in Oklahoma
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
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