Ray Tracing on Topographic Rossby Waves

Topographic Rossby Waves (TRWs) have been identified with the largest variability in deep current meter records along the continental slope in the Mid-Atlantic Bight (MAB). Ray tracing theory is applied to TRWs using the real bottom topography of the MAB and the observed stratification. The dispersion relation for TRWs is derived and various wavenumber limits are discussed. A computational method for tracing the waves is presented, including the necessity of smoothing the bathymetry. In the examples shown, TRW with periods of 24-48 days generally propagate southwestward, changing their wavelengths from 400 to 100 kilometers in response to the change in bottom slope. TRW paths are shown that connect from the SYNOP Central Array near 68oW to the SYNOP Inlet Array near Cape Hatteras

North Atlantic Current Inverted Echo Sounder Data Report

This report focuses on data from inverted echo sounders with pressure gauges (PIES) spanning the North Atlantic Current (NAC) east of the Grand Banks collected during August 1993 to July 1995. In this report the collection, processing and calibration of the PIES data are described and plotted. The measurements were made under the support of the Office of Naval Research and the National Oceanographic and Atmospheric Administration. Other data collected as part of the experiment included conductivity-temperature-depth (CTD) hydrographic surveys and velocity measurements obtained with moored current meters, shipboard acoustic Doppler current profilers, and POGO floats. These data were collected jointly by the Bedford Institute of Oceanography and the University of Rhode Island

Cues and knowledge structures used by mental-health professionals when making risk assessments

Background: Research into mental-health risks has tended to focus on epidemiological approaches and to consider pieces of evidence in isolation. Less is known about the particular factors and their patterns of occurrence that influence clinicians’ risk judgements in practice. Aims: To identify the cues used by clinicians to make risk judgements and to explore how these combine within clinicians’ psychological representations of suicide, self-harm, self-neglect, and harm to others. Method: Content analysis was applied to semi-structured interviews conducted with 46 practitioners from various mental-health disciplines, using mind maps to represent the hierarchical relationships of data and concepts. Results: Strong consensus between experts meant their knowledge could be integrated into a single hierarchical structure for each risk. This revealed contrasting emphases between data and concepts underpinning risks, including: reflection and forethought for suicide; motivation for self-harm; situation and context for harm to others; and current presentation for self-neglect. Conclusions: Analysis of experts’ risk-assessment knowledge identified influential cues and their relationships to risks. It can inform development of valid risk-screening decision support systems that combine actuarial evidence with clinical expertise

Urinary Tract Stones and Osteoporosis: Findings From the Women's Health Initiative

Kidney and bladder stones (urinary tract stones) and osteoporosis are prevalent, serious conditions for postmenopausal women. Men with kidney stones are at increased risk of osteoporosis; however, the relationship of urinary tract stones to osteoporosis in postmenopausal women has not been established. The purpose of this study was to determine whether urinary tract stones are an independent risk factor for changes in bone mineral density (BMD) and incident fractures in women in the Women's Health Initiative (WHI). Data were obtained from 150,689 women in the Observational Study and Clinical Trials of the WHI with information on urinary tract stones status: 9856 of these women reported urinary tract stones at baseline and/or incident urinary tract stones during follow‐up. Cox regression models were used to determine the association of urinary tract stones with incident fractures and linear mixed models were used to investigate the relationship of urinary tract stones with changes in BMD that occurred during WHI. Follow‐up was over an average of 8 years. Models were adjusted for demographic and clinical factors, medication use, and dietary histories. In unadjusted models there was a significant association of urinary tract stones with incident total fractures (HR 1.10; 95% CI, 1.04 to 1.17). However, in covariate adjusted analyses, urinary tract stones were not significantly related to changes in BMD at any skeletal site or to incident fractures. In conclusion, urinary tract stones in postmenopausal women are not an independent risk factor for osteoporosis. © 2015 American Society for Bone and Mineral Research.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115895/1/jbmr2553.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/115895/2/jbmr2553_am.pd

Accounting for heterogeneity in θ-σ relationship:application to wheat phenotyping using ΕMI

Geophysical methods, such as electromagnetic induction (EMI), can be effective for monitoring changes in soil moisture at the field scale, particularly in agricultural applications. The electrical conductivity (σ) inferred from EMI needs to be converted to soil moisture content (θ) using an appropriate relationship. Typically, a single global relationship is applied to an entire agricultural field, however, soil heterogeneity at the field scale may limit the effectiveness of such an approach. One application area that may suffer from such an effect is crop phenotyping. Selecting crop varieties based on their root traits is important for crop breeding and maximizing yield. Hence, high throughput tools for phenotyping the root system architecture and activity at the field-scale are needed. Water uptake is a major root activity and, under appropriate conditions, can be approximated by measuring changes in soil moisture from time-lapse geophysical surveys. We examine here the effect of heterogeneity in the θ-σ relationship using a crop phenotyping study for illustration. In this study, the θ-σ relationship was found to vary substantially across a field site. To account for this, we propose a range of local (plot specific) θ-σ models. We show that the large number of parameters required for these models can be estimated from baseline σ and θ measurements. Finally, we compare the use of global (field scale) and local (plot scale) models with respect to ranking varieties based on the estimated soil moisture content change

Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

Acknowledgements: The authors thank Mr. Maron Lee Barrett and Ms. Mayra Star for their technical help. The authors thank Dr. Dejian Ma for his technical help with the NMR studies. The authors thank the UTHSC and St. Jude NMR core for their help with the NMR studies. The authors thank Drs. Robert Getzenberg and Michael Mohler for providing useful comments on the manuscript. The authors thank Ms. Brandy Grimes for her help with tissue procurement. The authors thank Dr. Daniel Johnson of UT BioCore for microarray data analysis and Mr. Lorne Rose of UT-MRC core for microarray studies. Funding Source: The research presented in this manuscript was supported by a research funding provided by GTx, Inc. Memphis, TN to R. Narayanan and by a research funding provided by West Cancer Center to R. Narayanan.Peer reviewedPostprin

The initial mass function in the extended ultraviolet disc of M83

Using Hubble Space Telescope ACS/WFC data we present the photometry and spatial distribution of resolved stellar populations of four fields within the extended ultraviolet disc (XUV disc) of M83. These observations show a clumpy distribution of main-sequence stars and a mostly smooth distribution of red giant branch stars. We constrain the upper end of the initial mass function (IMF) in the outer disc using the detected population of main-sequence stars and an assumed constant star formation rate (SFR) over the last 300 Myr. By comparing the observed main-sequence luminosity function to simulations, we determine the best-fitting IMF to have a power-law slope α = −2.35 ± 0.3 and an upper mass limit M_u = 25⁺¹⁷₋₃M⊙⁠. This IMF is consistent with the observed H α emission, which we use to provide additional constraints on the IMF. We explore the influence of deviations from the constant SFR assumption, finding that our IMF conclusions are robust against all but strong recent variations in SFR, but these are excluded by causality arguments. These results, along with our similar studies of other nearby galaxies, indicate that some XUV discs are deficient in high-mass stars compared to a Kroupa IMF. There are over one hundred galaxies within 5 Mpc, many already observed with HST, thus allowing a more comprehensive investigation of the IMF, and how it varies, using the techniques developed here