144 research outputs found
A Phenomenological Study of Justice-Involved Veteran Experiences of Veterans Court
As of 2015, over 300 veterans treatment courts have opened across the nation in the United States, providing an alternative to incarceration to eligible justice-involved veterans. Despite the proliferation of veterans courts around the country, research on veteran experiences in veterans court is minimal at best. This study sought to examine veteran experiences in veterans treatment court through interpretive phenomenological analysis. Eight veterans from five western U.S. veterans treatment courts were interviewed regarding the circumstances of their referral to court, the treatment they received, their interactions with their treatment team, and how veteran identity impacted their receipt of treatment. Four themes emerged from the data analysis: 1) Veterans Treatment Court team as non-adversarial; 2) veteran support through identity and camaraderie; 3) challenges with required travel and scheduling; 4) perception of effort and personal responsibility. The findings of this study have implications that span problem-solving court research as well as mental health treatment of justice-involved veterans
Gender, Power and Property: āIn my own rightā
working paperWomen on farms in Ireland are a subject of feminist analysis for five
decades. Salient themes are the constraints of patriarchal agriculture
(O'Hara 1997; Shortall, 2004), the invisibility of women's farm work
(Viney 1968; OāHara 1998), gender inequalities in ownership of farm
assets (Watson et al. 2009) and increasing professionalisation of
farmwomen outside of agriculture (Kelly and Shortall 2002; Hanrahan
2007). Most women enter farming through marriage and family ties.
Land ownership is identified by Shortall (2004) as the critical factor
underpinning male domination of the occupational category āfarmerā
and considerable power differentials between men and women in
family farming. This is an area that requires further investigation. Our
analysis, framed by theoretical models of feminisation and
empowerment, explores cases where male farm property ownership
in Ireland is disrupted in conventional and non-conventional
agricultural settings. Do these cases provide evidence of new
opportunities for women to become farm property owners, and in
what contexts? What consequences do these opportunities have for
farmwomenās empowerment and agency? How does womenās farm
property ownership disturb rural gender relations in the context of
the family farm?Teagasc Walsh Fellowship Programm
Provider-initiated testing and counselling programmes in sub-Saharan Africa: a systematic review of their operational implementation.
OBJECTIVE: The routine offer of an HIV test during patient-provider encounters is gaining momentum within HIV treatment and prevention programmes. This review examined the operational implementation of provider-initiated testing and counselling (PITC) programmes in sub-Saharan Africa. DESIGN AND METHODS: PUBMED, EMBASE, Global Health, COCHRANE Library and JSTOR databases were searched systematically for articles published in English between January 2000 and November 2010. Grey literature was explored through the websites of international and nongovernmental organizations. Eligibility of studies was based on predetermined criteria applied during independent screening by two researchers. RESULTS: We retained 44 studies out of 5088 references screened. PITC polices have been effective at identifying large numbers of previously undiagnosed individuals. However, the translation of policy guidance into practice has had mixed results, and in several studies of routine programmes the proportion of patients offered an HIV test was disappointingly low. There were wide variations in the rates of acceptance of the test and poor linkage of those testing positive to follow-up assessments and antiretroviral treatment. The challenges encountered encompass a range of areas from logistics, to data systems, human resources and management, reflecting some of the weaknesses of health systems in the region. CONCLUSIONS: The widespread adoption of PITC provides an unprecedented opportunity for identifying HIV-positive individuals who are already in contact with health services and should be accompanied by measures aimed at strengthening health systems and fostering the normalization of HIV at community level. The resources and effort needed to do this successfully should not be underestimated
The food literacy action logic model: A tertiary education sector innovative strategy to support the charitable food sectors need for food literacy training
Food literacy is seen as a key component in improving the increasing levels of food insecurity. While responsibility for providing training falls on the charitable service organizations, they may not have the capacity to adequately reach those in need. This paper proposes a tertiary education - (university or higher education) led model to support the food literacy training needs of the food charity sector. A cross-sectional study comprised of online surveys and discussions investigated food services offered by Western Australia (WA) and Australian Capital Territory (ACT) agencies, food literacy training needs for staff, volunteers and clients, and challenges to delivering food literacy training programs. Purposive sampling was used, and ACT and WA charitable service originations (survey: ACT n = 23, WA n = 32; interviews: ACT n = 3, WA n = 2) were invited to participate. Findings suggest organizations had limited financial and human resources to address the gap in food literacy training. Nutrition, food budgeting, and food safety education was delivered to paid staff only with limited capacity for knowledge transfer to clients. The Food Literacy Action Logic Model, underpinned by a tertiary education engagement strategy, is proposed to support and build capacity for organizations to address training gaps and extend the reach of food literacy to this under-resourced sector
The management of depressed elderly care recipients : family perspectives on the skills of professional carers
Recent studies have identified high levels of depression among older people, both those in their own homes and those in residential care. With the world\u27s population ageing, it is timely for health service providers to consider how the escalating population of depressed elderly people will be managed. Although treating general practitioners may be the health professionals most expected to detect, treat, and monitor depression among the elderly, professional carers are well placed to assist in the detection and monitoring of the disorder. This study conducted individual interviews with 15 family members of depressed aged-care recipients to determine their perceptions of the skills and knowledge of depression of professional carers. Family members reported that carers are more likely to avoid than engage with their clients about depressive symptomatology and do not communicate their concerns with managers or general practitioners (GPs). Family members believed that, in general, professional carers were undertrained in these areas. The implications of these findings for health service planning and staff training are discussed. <br /
Accuracy of identification of tissue types in endoscopic esophageal mucosal biopsies used for molecular biology studies
Open Access Initiativ
Changes in vector species composition and current vector biology and behaviour will favour malaria elimination in Santa Isabel Province, Solomon Islands
Background: In 2009, Santa Isabel Province in the Solomon Islands embarked on a malaria elimination programme. However, very little is known in the Province about the anopheline fauna, which species are vectors, their bionomics and how they may respond to intensified intervention measures. The purpose of this study was to provide baseline data on the malaria vectors and to ascertain the possibility of successfully eliminating malaria using the existing conventional vector control measures, such as indoor residual spraying (IRS) and long-lasting insecticidal nets (LLIN). Methods. Entomological surveys were undertaken during October 2009. To determine species composition and distribution larval surveys were conducted across on the whole island. For malaria transmission studies, adult anophelines were sampled using human landing catches from two villages - one coastal and one inland. Results: Five Anopheles species were found on Santa Isabel: Anopheles farauti, Anopheles hinesorum, Anopheles lungae, Anopheles solomonis, and Anopheles nataliae. Anopheles hinesorum was the most widespread species. Anopheles farauti was abundant, but found only on the coast. Anopheles punctulatus and Anopheles koliensis were not found. Anopheles farauti was the only species found biting in the coastal village, it was incriminated as a vector in this study; it fed early in the night but equally so indoors and outdoors, and had a low survival rate. Anopheles solomonis was the main species biting humans in the inland village, it was extremely exophagic, with low survival rates, and readily fed on pigs. Conclusion: The disappearance of the two major vectors, An. punctulatus and An. koliensis, from Santa Isabel and the predominance of An. hinesorum, a non-vector species may facilitate malaria elimination measures. Anopheles farauti was identified as the main coastal vector with An. solomonis as a possible inland vector. The behaviour of An. solomonis is novel as it has not been previously found biting humans in any numbers. Both species appear to be short-lived, a characteristic that will limit their transmission potential. The early night feeding behaviour and a degree of outdoor biting seen in An. farauti and particularly in An. solomonis will require that their response to IRS and LLIN be closely monitored. In coastal villages, where large, favourable breeding sites allow for high numbers of An. farauti may require the addition of larval control to achieve elimination
Portunus: Re-imagining access control in distributed systems
TLS termination, which is essential to network and security infrastructure providers, is an extremely latency sensitive operation that benefits from access to sensitive key material close to the edge. However, increasing regulatory concerns prompt customers to demand sophisticated controls on where their keys may be accessed. While traditional access-control solutions rely on a highly available centralized process to enforce access, the round-trip latency and
decreased fault tolerance make this approach unappealing. Furthermore, the desired level of customer control is at odds with customizing the distribution process for each key.
To solve this dilemma, we have designed and implemented Portunus, a cryptographic storage and access control system built using a variant of public-key cryptography called attribute-based encryption (ABE). Using Portunus, TLS keys are protected using ABE under a policy chosen by the customer. Each server is issued unique ABE keys based on its attributes, allowing it to decrypt only the TLS keys for which it satisfies the policy. Thus, the encrypted keys can be stored at the edge, with access control enforced passively through ABE. If a server receives a TLS connection but is not authorized to decrypt the necessary TLS key, the request is forwarded directly to the nearest authorized server, further avoiding the need for a centralized coordinator. In comparison, a trivial instantiation of this system using standard public-key cryptography might wrap each TLS key with the key of every authorized data center. This strategy, however, multiplies the storage overhead by the number of data centers. We have deployed Portunus on Cloudflare\u27s global network of over 400 data centers. Our measurements indicate that we can handle millions of requests per second globally, making it one of the largest deployments of ABE
Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma
Author version made available in accordance with publisher policy.Abstract
Background The poor prognosis and rising incidence of esophageal adenocarcinoma highlight the need for improved detection
methods. The potential for circulating microRNAs (miRNAs) as biomarkers in other cancers has been shown, but circulating
miRNAs have not been well characterized in esophageal adenocarcinoma. We investigated whether circulating exosomal
miRNAs have potential to discriminate individuals with esophageal adenocarcinoma from healthy controls and non-dysplastic
Barrettās esophagus.
Methods Seven hundred fifty-eight miRNAs were profiled in serum circulating exosomes from a cohort of 19 healthy controls,
10 individuals with Barrettās esophagus, and 18 individuals with locally advanced esophageal adenocarcinoma. MiRNA expression
was assessed using all possible permutations of miRNA ratios per individual. Four hundred eight miRNA ratios were
differentially expressed in individuals with cancer compared to controls and Barrettās esophagus (Mann-Whitney U test,
P<0.05). The 179/408 ratios discriminated esophageal adenocarcinoma from healthy controls and Barrettās esophagus (linear
regression, P0.7, P<0.05). A multi-biomarker panel (RNU6-1/miR-
16-5p, miR-25-3p/miR-320a, let-7e-5p/miR-15b-5p, miR-
30a-5p/miR-324-5p, miR-17-5p/miR-194-5p) demonstrated
enhanced specificity and sensitivity (area under ROC=0.99,
95 % CI 0.96ā1.0) over single miRNA ratios to distinguish
esophageal adenocarcinoma from controls and Barrettās
esophagus.
Conclusions This study highlights the potential for serum
exosomal miRNAs as biomarkers for the detection of esophageal
adenocarcinoma
Pre-therapy mRNA expression of TNF is associated with regimen-related gastrointestinal toxicity in patients with esophageal cancer: a pilot study
Author version made available following 12 month embargo from date of publication (27 March 2015) in accordance with publisher copyright policy.Purpose
Esophageal cancer has a high mortality rate, and its multimodality treatment is often associated with significant rates of severe toxicity. Effort is needed to uncover ways to maximize effectiveness of therapy through identification of predictive markers of response and toxicity. As such, the aim of this study was to identify genes predictive of chemoradiotherapy-induced gastrointestinal toxicity using an immune pathway-targeted approach.
Methods
Adults with esophageal cancer treated with chemotherapy consisting of 5-fluorouracil and cisplatin and 45ā50 Gy radiation were recruited to the study. Pre-therapy-collected whole blood was analyzed for relative expression of immune genes using real-time polymerase chain reaction (RT-PCR). Gene expression was compared between patients who experienced severe regimen-related gastrointestinal toxicity vs. those experiencing mild to moderate toxicity.
Results
Blood from 31 patients were analyzed by RT-PCR. Out of 84 immune genes investigated, TNF was significantly elevated (2.05-fold, pā=ā0.025) in the toxic group (nā=ā12) compared to the non-toxic group (nā=ā19). Nausea and vomiting was the most commonly documented severe toxicity. No associations between toxicity and response, age, sex, histology, or treatment were evident.
Conclusions
This study supports evidence of TNF as a predictive biomarker in regimen-related gastrointestinal toxicity. Confirming these findings in a larger cohort is warranted
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