Object’s Optical Geometry Measurements Based on EDoF Approach

Machine vision applications are getting more popular in many manufacturing applications. Although vision techniques have many advantages there are still numerous problems related with those methods. One of the drawbacks is that when measuring or performing an inspection task the image resolution must be as high as possible. When inspecting an object of complicated geometry, with a specific lens and camera to achieve a given accuracy, the field of view, or the depth of field might be insufficient for the task. Using cameras placed on manipulators, or on moving stages leads to solving the problem, but it also causes various implementation issues. During the measurement process when the camera or the inspected object is moving, images are acquired and need to be processed separately. If the inspection task is a simple feature extraction might be sufficient. On the other hand if the image processing is more complex it might take time to process each image separately. For example when a feature is located on the border of a image, to measure it or properly assess, two or more images with the feature need to be combined. When it comes to field of view limitations, there are known methods of image stitching, and combining [1,2]. When the depth of field is narrow, for example when using fixed telecentric lenses the problem is more complex. The Extended Depth of Field (EDoF) is an approach known in microscopy imagining. It allows to stitch images taken form a range of distances that are minimum spaced. Acquiring images of the same object with differently placed depth of field reveals elements otherwise hidden (due to shallow depth of field). The methods of extracting information form a set of images taken with different depths of field is known in microscopy and wieldy used [3,4]. On the other hand using EDoF in non-microscopic inspections is not utilized because of the fact of changing the focal distance from the inspected object leads to resizing the object in the frame. The longer the focal length the higher is the compression rate of the imagining. The authors propose a method of using EDoF in macro inspections using bi-telecentric lenses and a specially designed experimental machine setup, allowing accurate focal distance changing. Also a software method is presented allowing EDoF image reconstruction using the continuous wavelet transform (CWT). Exploited method results are additionally compared with measurements performed with Keyence’s LJ-V Series in-line Profilometer for reference matters

Weld Joints Inspection Using Multisource Data and Image Fusion

The problem of inspecting weld joints is very complex, especially in critical parts of machines and vehicles. The welded joint is typically inspected visually, chemically or using radiography imaging. The flaw detection is a task for specialized personnel who analyze all the data on each stage of the inspection process separately. The inspection is prone to human error, and is labor intensive. In the stages of weld joint visual control geometrical measurements are performed, joint alignment, straightness, deformation, as well as the weld\u27s uniformity. Coloration my show the heat impact zone, and melted parts of the base material. Also during this stage the unwanted cracks, pores and other surface defects can be spotted. On the other side during the X-ray inspection other flaws can be discovered. Pores, cracks, lack of penetration and slag inclusions can be observed. The author’s goal was to develop a multisource data system of easier flaw detection, and possibly inspection process automation. The methods consisted of three image sources: X-ray, laser profilometer, and imaging camera. The proposed approach consists combining spatial information in the acquired data from all sources. A novel approach of data mixing is proposed to benefit from all the information. The signal form the profilometer enables geometrical information extraction. Deformation and alignment error assessment. The radiogram provides information about the hidden flaws. The color image gives information about texture and color of the surface as well as helps in combining multiple sources

Primary immune thrombocytopenia in a patient with sarcoidosis

Sarkoidoza cechuje się zróżnicowanym obrazem klinicznym. Może współwystępować z różnorodnymi schorzeniami o immunologicznym podłożu, jednak rzadko towarzyszą jej choroby układu krwiotwórczego. W pracy przedstawiono przypadek współwystępowania pierwotnej małopłytkowości immunizacyjnej o nagłym początku i sarkoidozy. Częstość występowania pierwotnej małopłytkowości immunizacyjnej wśród chorych z sarkoidozą ocenia się na około 2%, a w grupie osób z małopłytkowością sarkoidozę rozpoznaje się u 1% chorych. Opisano 3 potencjalne patomechanizmy prowadzące do ujawnienia się małopłytkowości w sarkoidozie: 1) obecność autoprzeciwciał przeciwpłytkowych, 2) obecność ziarniniaków nabłonkowatokomórkowych w szpiku, 3) hipersplenizm. Pneumonol. Alergol. Pol. 2011; 79, 5: 371–376Sarcoidosis is a disease characterised by a highly variable clinical course. While it may be accompanied by various immune disorders, it is rarely accompanied by disorders of the haematopoietic system. We report a case of sudden-onset primary immune thrombocytopenia co-existing with sarcoidosis. The prevalence of primary immune thrombocytopenia in patients with sarcoidosis is estimated at about 2% and about 1% of patients with thrombocytopenia are diagnosed with sarcoidosis. Three potential pathomechanisms leading to the development of thrombocytopenia in sarcoidosis have been described, namely: (1) the presence of antiplatelet antibodies, (2) presence of epithelioid cell granulomas in the bone marrow and (3) hypersplenism. Pneumonol. Alergol. Pol. 2011; 79, 5: 371–37

Niespokrewnieni dawcy komórek macierzystych — motywacja i satysfakcja w procesie donacji komórek krwiotwórczych

Background. Poland has the most rapidly growing population of registered stem cell donors worldwide. The aim of the study was the analysis of motivation, ways of recruitment, major side effects and general satisfaction related to donation process among unrelated hematopoietic stem cell (HSC) donors at a major stem cell facility in Poland. Material and methods. The prospective study was based on data from online questionnaire completed by unrelated HSC donors — before and after donation. The study included 109 questionnaires completed prior to donation and 80 questionnaires completed after donation. Results. The wish to help others was motivation for registration in 84% of the donors. The most common recruitment site were local actions (49%), the Internet however has also become a major source of registration — 42% of donors were recruited through the Internet based service. The most common side effects or general discomforts related to donation as reported by donors were: G-CSF injections (45%) and duration of the procedure (29%) in the case of peripheral blood stem cell donors (PBSC) and in the case of bone marrow harvest in general anesthesia — weakness after donation (27%), duration of hospital stay (27%) as well as pain after intubation (18%). Pain related to G-CSF mobilization procedure was higher than that reported after bone marrow harvest (1.51 vs 0.67; p = 0,83). Only 6% PBSC donors regarded this pain as significant compared to 9% of marrow donors. Conclusion. The outcome of the study provides a positive overview of stem cell donation in Poland. Stem cell donors report satisfaction with information provided by health care personnel on recruitment, qualification and donation procedure, the procedure-related side effects and discomforts are few and the sense of contentment and satisfaction is high.Wstęp. W ostatnich latach polski rejestr niespokrewnionych dawców komórek krwiotwórczych był najszybciej rozwijającym się rejestrem w skali świata. Celem niniejszej pracy jest analiza procesu rekrutacji i pobierania komórek macierzystych od dawców. Analizę tę przeprowadzono w największym ośrodku pobierającym w Polsce — w Samodzielnym Publicznym Centralnym Szpitalu Klinicznym. Materiał i metody. Przeprowadzono badanie ankietowe online wśród niespokrewnionych dawców komórek krwiotwórczych przed donacją i po. Łącznie dawcy wypełnili 109 kwestionariuszy przed donacją i 80 kwestionariuszy po donacji. Wyniki. Chęć niesienia pomocy drugiemu człowiekowi była głównym powodem rejestracji dla 84% dawców. Najczęściej rekrutowano ich podczas lokalnych akcji (49% dawców) i przez Internet — poprzez kwestionariusze dostępne w sieci (42%). Najczęściej zgłaszanymi przez dawców niedogodnościami związanymi z pobraniem komórek były: konieczność wykonywania zastrzyków czynnika wzrostu granulocytów (45%) i czas trwania procedury (29%) — wśród dawców komórek krwiotwórczych z krwi obwodowej — oraz osłabienie po pobraniu (27%), konieczność pobytu w szpitalu (27%) i ból gardła po intubacji (18%) związane z pobraniem szpiku w znieczuleniu ogólnym. Natężenie bólu zgłaszanego przez dawców w trakcie pobrania komórek z krwi obwodowej było większe niż u dawców po pobraniu szpiku, ale nie była to różnica istotna statystycznie (1,51 vs 0,67; p = 0,83). Tylko 6% dawców komórek z krwi obwodowej uważało ten ból za istotny w porównaniu do 9% dawców, od których pobierano szpik. Wnioski. Wyniki pracy pokazują pozytywny obraz donacji komórek krwiotwórczych. Zadowolenie z otrzymanych informacji w trakcie rekrutacji, kwalifikacji i donacji, mała liczba niekorzystnych doświadczeń dawców oraz ogólne zadowolenie z przebiegu donacji przyczyniają się do kształtowania pozytywnego obrazu dawstwa i przeszczepiania szpiku w Polsce

Outcome of Second Primary Malignancies Developing in Multiple Myeloma Patients

Background: There is an increased risk of second primary malignancies (SMPs) in patients with multiple myeloma (MM). This multinational 'real-world' retrospective study analyzed the characteristics and outcomes of MM patients that developed SPMs.Results: 165 patients were analyzed: 62.4% males; 8.5% with a prior cancer; 113 with solid SPMs, mainly =stage 2; and 52 with hematological SPM (hemato-SPM), mainly MDS/AML. Patients with hemato-SPM were younger (p = 0.05) and more frequently had a prior AutoHCT (p = 0.012). The time to SPM was shorter in the older (>65 years) and more heavily pretreated patients. One hundred patients were actively treated at the time of SPM detection. Treatment was discontinued in 52, substituted with another anti-MM therapy in 15, and continued in 33 patients. Treatment discontinuation was predominant in the patients diagnosed with hemato-SPM (76%). The median OS following SPM detection was 8.5 months, and the main cause of death was SPM. A poor ECOG status predicted a shorter OS (PS 3 vs. 0, HR = 5.74, 2.32-14.21, p < 0.001), whereas a normal hemoglobin level (HR = 0.43, 0.19-0.95, p = 0.037) predicted longer OS.Conclusions: With the continuing improvement in OS, a higher proportion of MM patients might develop SPM. The OS following SPM diagnosis is poor; hence, frequent surveillance and early detection are imperative to improve outcomes

Diagnosis of myelodysplastic syndromes in Poland: Polish Adult Leukemia Group (PALG) 2021 recommendations

Myelodysplastic syndromes (MDS) are a heterogeneous group of neoplastic diseases of the hematopoietic cells manifested by ineffective hematopoiesis and a tendency to transform into acute myeloid leukemia. MDS should be considered in the differential diagnosis of cytopenia, especially in the elderly. This article presents the recommendations of MDS experts of the Polish Adult Leukemia Group (PALG) for the diagnosis of myelodysplastic syndromes. We present current classifications and prognostic indices, as well as diagnostic examinations recommended for MDS: cytological, histopathological, immunophenotypic, cytogenetic and molecular tests. The aim of the study is to implement up-to-date knowledge about myelodysplastic syndromes into routine clinical practice, from the diagnosis of cytopenia to the specific diagnosis and prognosis in MDS patients.  Myelodysplastic syndromes (MDS) are a heterogeneous group of neoplastic diseases of the hematopoietic cells manifested by ineffective hematopoiesis and a tendency to transform into acute myeloid leukemia. MDS should be considered in the differential diagnosis of cytopenia, especially in the elderly. This article presents the recommendations of MDS experts of the Polish Adult Leukemia Group (PALG) for the diagnosis of myelodysplastic syndromes. We present current classifications and prognostic indices, as well as diagnostic examinations recommended for MDS: cytological, histopathological, immunophenotypic, cytogenetic and molecular tests. The aim of the study is to implement up-to-date knowledge about myelodysplastic syndromes into routine clinical practice, from the diagnosis of cytopenia to the specific diagnosis and prognosis in MDS patients.

Praktyka kliniczna oceny minimalnej choroby resztkowej u chorych na szpiczaka plazmocytowego w Polsce: badanie ankietowe Polskiego Konsorcjum Szpiczakowego

Studies exploring the significance of minimal residual disease (MRD) in plasma cell myeloma (PCM) have proven its prognostic value, regardless of the type of administered treatment. In order to assess the current practice for evaluating MRD in Poland, we conducted a survey on the methods for assessing MRD and on the MRD testing time points at Polish hematological centres. Seven out of 15 institutions surveyed use of the flow cytometry (FC) method for MRD assessment. The FC-MRD assessment is performed uniformly only in those patients achieving complete remission(CR). However, the specific indications and assessment time points differed at the tested centres including: testing MRD only after autologous hematopoietic stem cell transplantation (auto-HSCT), after auto-HSCT and consolidation, after completion of first line chemotherapy or after obtaining CR in any line of treatment. The study also showed considerable heterogeneity in the FC-MRD methodology, which affects test sensitivity (from 10–3 to 10–5). None of the surveyed centres uses molecular techniques for MRD assessment. In 8 of the 15 institutions, patients are monitored by imaging techniques. Our survey may thus be useful for developing guidelines and standardization of MRD assessment in PCM in Poland.W badaniach nad znaczeniem minimalnej choroby resztkowej (MRD) w szpiczaku plazmocytowym (PCM) dowiedziono, że status MRD ma wartość prognostyczną niezależnie od zastosowanego leczenia. W celu poznania zasad monitorowania MRD u chorych na PCM w polskich ośrodkach hematologicznych przeprowadzono badanie ankietowe. W ankiecie zadano pytania dotyczące stosowanych metod wykrywania MRD oraz punktów czasowych, w których badania są wykonywane. W 7 z 15 ośrodków objętych badaniem ankietowym oznaczenia MRD w PCM wykonuje się w aspiratach szpiku kostnego metodą cytometrii przepływowej (FC). We wszystkich ośrodkach oznaczenia FC-MRD są wykonywane jedynie u chorych w całkowitej remisji (CR), jednak w różnych punktach czasowych — tylko po autologicznym przeszczepieniu krwiotwórczych komórek macierzystych (allo-HSCT), po allo-HSCT i konsolidacji, po zakończeniu leczenia pierwszej linii lub, w przypadku uzyskania CR, po dowolnej linii leczenia. Stwierdzono ponadto znaczne różnice w sposobie wykonywania badania FC-MRD wpływające na osiąganą czułość detekcji MRD (od 10–3 do 10–5). W żadnym z ankietowanych ośrodków nie ocenia się MRD w szpiku kostnym technikami molekularnymi. Monitorowanie choroby resztkowej metodami obrazowymi stosuje personel 8 z 15 ośrodków. Wyniki przeprowadzonej ankiety mogą posłużyć wypracowaniu wspólnych wytycznych i standaryzacji oceny MRD w PCM w Polsce

Analysis of ibrutinib efficacy in a subgroup of chronic lymphocytic leukemia patients with 17p deletion: observational study of the Polish Adult Leukemia Group (PALG)

BackgroundThe 17p deletion is regarded as the strongest poor prognostic factor in chronic lymphocytic leukemia (CLL). Results of recently performed clinical trials have suggested that ibrutinib significantly improves the outcome in this patient group.AimThe study aimed at analyzing the efficacy and adverse events profile of ibrutinib monotherapy in CLL patients with 17p deletion treated in routine clinical practice outside clinical trials.Materials and MethodsClinical response and adverse events profile of ibrutinib monotherapy were assessed in thirty-five CLL patients with 17p deletion treated within the ibrutinib named patients program in Poland.ResultsOverall response rate was 80% (28/35 patients) with median observation time of 24.2 months (range 0,1 – 30,9). Complete remission was observed in 5 patients (14.3%), partial remission in 11 (31.4%), partial remission with lymphocytosis in 13 (37.1%), whereas stable disease and progression was noted in 4 (11.4%) and 1 (2.9%) respectively. Response was not assessed in 1 patient. Median progression-free survival was 29.5 months, whereas median overall survival was not reached. Eleven patients died (7 because of infection, 1 of CLL progression, 1 of sudden cardiac death, 1 of disseminated breast cancer and 1 of unknown causes). In 13 patients (37.1%) at least one 3 or 4 grade adverse event occurred. In 11 patients (31.4%) the treatment was temporary withheld or the dose reduced due to adverse events.ConclusionIbrutinib is characterized by high clinical efficacy and acceptable toxicity in CLL patients with 17p deletion in daily clinical practice

MC_MoveAbsolute() 4th Order Real-Time Trajectory Generation Function Algorithm and Implementation

This paper presents the issue of generating motion trajectories in a digital servo drive in accordance with the PLCopen Motion Control standard. This standard does not limit the details of motion generation in the electromechanical systems, but indicates its interface and set of necessary parameters. Moreover, it is placed within a state machine, which allows the individual software elements to integrate with it seamlessly. This work discusses time-optimal point-to-point trajecto-ries, i.e., the initial and final reference speeds are zero, and they are compliant with the MC_MoveAbsolute() function defined in the PLCopen Motion Control standard. The smoothness of the resulting trajectory can be attributed to the use of a fourth order trajectory generator, which defines the bounds up to snap ⁻ the second derivative of acceleration. One of the aims of this article was to bridge the theoretical aspect of trajectory generation with the algorithms practical implementation, by the means of PLC code generation using the MATLAB/Simulink package