Cykl artykułów Aleksandry Kołłontaj w piśmie „Die Gleichheit” o sytuacji ekonomicznej rosyjskich pracownic

Этот материал представляет польским читателям и исследователям серию статей Александры Коллонтай, опубликованных на страницах трех номеров немецкого органа социал-демократии ”Die Gleichheit” в 1910 г. (№ 24, 25, 26) Известная женщина-революционер, используя свое экономическое знания начертала картину проблемов работников индустрии. Много из них возбуждает дисскусии до сих пор, как н.п. грудное вскармливание ребенков на рабочем месте или явление полового преследования

Bortezomib plus melphalan and prednisone for initial treatment of plasma cell myeloma in transplant-ineligible patient with renal failure

Niewydolność nerek pogarsza rokowanie chorych na szpiczaka plazmocytowego (PCM). W artykule przedstawiono opis 82-letniego chorego na PCM klasy IgG lambda w stadium zaawansowania klinicznego IIIB według Durie-Salmona, o 3. stopniu zaawansowania według Międzynarodowego Systemu Prognostycznego, ze współistniejącą niewydolnością nerek, leczonego bortezomibem w skojarzeniu z melfalanem i prednizonem. Dotychczas pacjent uzyskał bardzo dobrą odpowiedź częściową na leczenie. Poprawa jakości odpowiedzi na leczenie chorych na PCM dotyczy także osób po 75. roku życia leczonych zgodnie z protokołami chemioterapii opartymi na nowych lekach.Renal failure worsens prognosis of patients with plasma cell myeloma (PCM). The case of 82-year old patient diagnosed with PCM, categorized as stage IIIB according to Durie-Salmon classification, as stage III according to International Staging System classification and renal impairment treated with regimen containing bortezomib, melphalan, prednisone, was presented. As far the patient achieved very good partial response to treatment. Improvement of quality of response is also remarkable in patients with PCM older than 75 years old, treated with chemotherapy based on novel drugs

Analysis of ibrutinib efficacy in a subgroup of chronic lymphocytic leukemia patients with 17p deletion: observational study of the Polish Adult Leukemia Group (PALG)

BackgroundThe 17p deletion is regarded as the strongest poor prognostic factor in chronic lymphocytic leukemia (CLL). Results of recently performed clinical trials have suggested that ibrutinib significantly improves the outcome in this patient group.AimThe study aimed at analyzing the efficacy and adverse events profile of ibrutinib monotherapy in CLL patients with 17p deletion treated in routine clinical practice outside clinical trials.Materials and MethodsClinical response and adverse events profile of ibrutinib monotherapy were assessed in thirty-five CLL patients with 17p deletion treated within the ibrutinib named patients program in Poland.ResultsOverall response rate was 80% (28/35 patients) with median observation time of 24.2 months (range 0,1 – 30,9). Complete remission was observed in 5 patients (14.3%), partial remission in 11 (31.4%), partial remission with lymphocytosis in 13 (37.1%), whereas stable disease and progression was noted in 4 (11.4%) and 1 (2.9%) respectively. Response was not assessed in 1 patient. Median progression-free survival was 29.5 months, whereas median overall survival was not reached. Eleven patients died (7 because of infection, 1 of CLL progression, 1 of sudden cardiac death, 1 of disseminated breast cancer and 1 of unknown causes). In 13 patients (37.1%) at least one 3 or 4 grade adverse event occurred. In 11 patients (31.4%) the treatment was temporary withheld or the dose reduced due to adverse events.ConclusionIbrutinib is characterized by high clinical efficacy and acceptable toxicity in CLL patients with 17p deletion in daily clinical practice

Common Strategies and Factors Affecting Off-Line Breath Sampling and Volatile Organic Compounds Analysis Using Thermal Desorption-Gas Chromatography-Mass Spectrometry (TD-GC-MS)

An analysis of exhaled breath enables specialists to noninvasively monitor biochemical processes and to determine any pathological state in the human body. Breath analysis holds the greatest potential to remold and personalize diagnostics; however, it requires a multidisciplinary approach and collaboration of many specialists. Despite the fact that breath is considered to be a less complex matrix than blood, it is not commonly used as a diagnostic and prognostic tool for early detection of disordered conditions due to its problematic sampling, analysis, and storage. This review is intended to determine, standardize, and marshal experimental strategies for successful, reliable, and especially, reproducible breath analysi

University in time and space – dimensions of bureaucracy at the Siedlce University of Natural Science and Humanities

Tekst skupia się na próbie wymiarowania biurokracji uniwersyteckiej na przykładzie Uniwersytetu Przyrodniczo-Humanistycznego w Siedlcach. Jest to podstawą do zaproponowania strategii zmniejszenia biurokracji oraz identyfikacji czynników, które mogą przyczynić się do jej wzrostu. Metody badawcze obejmują analizę literatury, obserwację i badania ankietowe

PARSEME – PARSing and Multiword Expressions within a European multilingual network

International audienceThe aim of this paper is to present PARSEME, a COST Action devoted to the issue of Multiword Expressions in parsing and in linguistic resources (corpora, lexicons). This is a “meta-paper” intended to be the main citation point for any future work referring to PARSEME: it does not describe in detail any single result of the Action, but rather summarises its multifarious activities and provides links to such results (both completed and in progress)

PARSEME – PARSing and Multiword Expressions within a European multilingual network

International audienceThe aim of this paper is to present PARSEME, a COST Action devoted to the issue of Multiword Expressions in parsing and in linguistic resources (corpora, lexicons). This is a “meta-paper” intended to be the main citation point for any future work referring to PARSEME: it does not describe in detail any single result of the Action, but rather summarises its multifarious activities and provides links to such results (both completed and in progress)

PARSEME – PARSing and Multiword Expressions within a European multilingual network

International audienceThe aim of this paper is to present PARSEME, a COST Action devoted to the issue of Multiword Expressions in parsing and in linguistic resources (corpora, lexicons). This is a “meta-paper” intended to be the main citation point for any future work referring to PARSEME: it does not describe in detail any single result of the Action, but rather summarises its multifarious activities and provides links to such results (both completed and in progress)