The Silent Threat Below: A Comprehensive Analysis of Manhole Gases and Health Effects

Manhole gases, often hidden underground in cities, can be really harmful to our health. This review looks at all the important aspects of these gases. It starts by talking about the different types of manhole gases, where they come from, and how common they are in cities. Then, it explains how people can be exposed to these gases, either by breathing them in or through their skin, with real-life examples to help understand better. Next, it talks about how these gases can make people sick, both in the short term with symptoms like dizziness and in the long term, leading to problems like lung diseases or issues with the brain. It also mentions that some people, like kids and older folks, are more at risk. To protect people from these dangers, the review suggests a few important ideas. It says we need to make sure workers and anyone near manholes are safe by following strict rules and using special gear. We also need to come up with new technologies and ideas to find and stop these gases from being a problem. Everyone must know about these risks, so there should be campaigns to tell people how to stay safe. In short, this review tells us that manhole gases are a serious concern for our health in cities. But by using smart strategies and keeping an eye out for these dangers, we can make sure everyone stays safe

Blood pressure measurement in overweight, underweight and normal BMI undergraduate students of a private medical college: correlation of BMI with blood pressure

Background: It is estimated that by 2025 around 46.5% of India’s population will be suffering from hypertension and associated complications. Thus, early detection of hypertension can prevent complications in later life. Higher BMI is associated with increased risk of elevated blood pressure. Weight related problems are on rise in college/University students. The medical students are at greater risk owing to various stressors. Thus, the present study was undertaken to measure blood pressure and BMI of undergraduate MBBS students and to find correlation with them.Methods: 253 students were enrolled in the study. BMI (Kg/m2) and blood pressure (mmHg) were measured. The data was analysed using appropriate statistical tests.Results: BMI was 22.54±2.85 and 20.75±2.99 Kg/m2 respectively in males and females (p<0.001). 21.34% and 12.65% were found to be underweight and overweight respectively.  SBP and DBP in males and females was found to be 120.54±9.48/79.71±4.77 and 110.80±0.98/74.40±5.45 mmHg respectively (p<0.001). 67.98%, 28.07% and 3.95% students were found to be normo, pre-and hypertensive respectively. Significant positive correlation of BMI with SBP and DBP was found both in males and females.Conclusions: There is weight related concerns and associated complications like elevated blood pressure in medical students

Phytochemistry and Medicinal Importance of Honey - A Review

Honey is the God gift to human being and has been successfully used for medicinal purpose since antiquity. The medicinal and nutritional properties of honey depend on its chemical constituents. Although the chief constituents are sugars and water, but the presence of other composition as Carbohydrate, Proteins, Vitamins as well as minerals make it very beneficial for nutritional, preservative and therapeutic properties as well. Pharmacological profile of honey is quite large as being having anti-inflammatory, antioxidant, immune modulator and anti-cancerous activities as revealed by various studies. Present paper provides a brief review of Phytochemistry and medicinal properties of honey

A Novel Technique for Secure Information Transmission in Videos Using Salt Cryptography

This paper presents a new technique for transmitting secret information securely from one party to another by embedding this information into a video after encryption through salt cryptography. We have tried to utilize the advantages of salt cryptography which has been ignored by data hiding community. In this encryption method some random data is added to the secret keys and passwords. We will define this random data as a salt which is needed to access the encrypted data, along with the password. Alone these passwords have no use since they will be able to locate the hidden data only when mixed with proper salt. This salt is managed by a certified third party. Different salt is created for different pairs of communicating parties. The purpose of salt is to add arbitrary random data to the string being hashed, such that you increase the length of input to hash. We have also introduced the concept of Enterprise Dependent Value (EDD), which are the embedding values corresponding to the binary digits and are specific to the communicating enterprises. The effectiveness of the techniques has been shown through experimental results. The performance of the proposed technique has been compared with the other techniques of watermarking, steganography and encryption. Keywords: Cryptography, Decryption , Encryption , Salt, Steganography , Video watermarkin

Holistic Approach in the Management of Depression: A Review

Emotions are the basic feelings of human beings. All of us have felt unhappy, “down,” or discouraged at times in our lives. But when somebody feels anxious, hopeless, helpless, worthless, guilty, hurt, restless or irritable, it comes under the categorization of depression. Depression is a disorder of mood that produces sad feelings, negative thoughts, disruptions of sleep, appetite, thinking, and energy level. Globally, more than 300 million people of all ages suffer from depression. The burden of depression is 50% higher for females than males. USM enlists whole Usool-e-ilaj of depression under the heading of ilaj bil ghiza, ilaj bil dawa and ilaj bil tadbeer. In ilaj bil dawa many drugs have been used for the treatment of depression but herbal medications in psychiatry are under research while more than 20 herbal remedies have been identified that may potentially be applied in medicine as anti-depressive, anxiety-relieving or sleep-inducing agents.

Optimisation of Ultra-High-Performance Concrete with Special Quarry Dust

The cement composition of concrete directly affects the CO2 emissions to the environment. UHPC (Ultra High-Performance Concrete) is a new type of concrete rapidly gaining popularity in the building industry due to its superior strength and endurance. In contrast to regular concrete, UHPC requires more than twice as much cement, making it more expensive and leaving a more significant carbon imprint. In this study, waste cement was substituted with 4%, 8%, and 12% special quarry dust from a manufacturer in Kuantan, Malaysia. Maximum compressive strength and quarry dust percentage are determined through experimentation and assessed in Design Expert Software. This investigation tested modified UHPC for strength, durability, and scanning electron microscope (SEM)&nbsp;appearance. Experiments show that substituting 21% quarry dust for cement yields the best outcomes. Since the particle size of quarry dust is finer than that of other matrices, it helps to reduce voids and boosts the UHPC's endurances. The quarry dust adds filler and a minor increase in viscosity to the UHPC, which is a better replacement for anhydrate cement in filler applications

Optimisation of Ultra-High-Performance Concrete with Special Quarry Dust

The cement composition of concrete directly affects the CO2 emissions to the environment. UHPC (Ultra High-Performance Concrete) is a new type of concrete rapidly gaining popularity in the building industry due to its superior strength and endurance. In contrast to regular concrete, UHPC requires more than twice as much cement, making it more expensive and leaving a more significant carbon imprint. In this study, waste cement was substituted with 4%, 8%, and 12% special quarry dust from a manufacturer in Kuantan, Malaysia. Maximum compressive strength and quarry dust percentage are determined through experimentation and assessed in Design Expert Software. This investigation tested modified UHPC for strength, durability, and scanning electron microscope (SEM)&nbsp;appearance. Experiments show that substituting 21% quarry dust for cement yields the best outcomes. Since the particle size of quarry dust is finer than that of other matrices, it helps to reduce voids and boosts the UHPC's endurances. The quarry dust adds filler and a minor increase in viscosity to the UHPC, which is a better replacement for anhydrate cement in filler applications

DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW SUBSTITUTED THIAZOLIDIN-4- ONE DERIVATIVES

4-thiazolidinones are among t h e most extensively investigated class of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities.They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial,anti-HIV,CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, it was thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleus is linked to another biologically active moiety.Semicarbazide/Thiosemicarbazide was reacted with b e n z o y l chloride to obtain N-hydrazinocarbonyl benzene-1-carboxamide/N-hydrazinocarbothioylbenzene-1 carboxamide respectively.These were then condensed with various aldehydes to yield the intermediate Schiff bases. Thiazolidin-4-ones were prepared by the reaction of Schiff bases with mercaptoacetic acid in dry benzene by refluxing for 16-18 hours. The purity of the compounds synthesized was established by TLC.The synthesiz ed derivatives were characteriz ed by FT-IR, 1HNMR and Mass spectral analysis. All the derivatives synthesized were screened for their anti-bacterial and antifungal activities using cup-plate method against Bacillus subtilis, Salmonella typhi, Escherichia coli, Staphylococcus aureus, Aspergillus niger and Candida albicans at 100µ g/ml using ciprofloxacin and clotrimazole as reference standard drugs respectively.The compounds belonging to series (3A1-3A6) have shown promising antibacterial and antifungal activity and those belonging to series (3B1-3B6) were moderate compared to standard. The antimicrobial activity data reveals that, the compounds bearing the phenyl carbonyl urea in their structure, were found to be more potent than the phenyl carbonyl thiourea containing derivatives, indicating the influence of oxygen in enhancing the antimicrobial potency. Keywords: Schif bases,Thiazolidin-4-one,Antimicrobia

STUDIES ON THE SYNTHESIS OF SOME NEW 1,2,4- TRIAZOLES DERIVATIVES AND EVALUATION FOR THEIR ANTI-FUNGAL ACTIVITY PROFILES

The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties. The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities .During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3- hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a- 6e)were synthesized by reacting withN-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4- yl)isonicotinamide (5) and aliphatic dicarboxylic acid hydrazides (a-e). The structures of the newly All the compounds synthesised 6a to 6e were evaluated for antifungal activity against Candida albicans and Aspergillus Niger was carried out and MIC values were determined synthesized compounds were estblished by FT-IR, 1H-NMR and MASS spectral analysis. The compound 6a (n=0) was found to be the most potent antifungal agent. Keywords: 1,2,4-triazole derivatives, antifungal, Candida albicans, Aspergillus Nige

Efficacy and safety of high dose accelerated intravenous iron sucrose in patients of iron deficiency anemia

Background: Low dose (200 mg) extended Intravenous iron sucrose remains the most common treatment option in patients who are intolerant to oral iron therapy in patients with Iron deficiency anemia (IDA). The objective of this study was to evaluate the efficacy and safety of high dose accelerated intravenous iron sucrose (IS) in the treatment of adults with iron deficiency anemiaMethods: One hundred adult patients with iron deficiency anemia, who had intolerance or showed no effect with oral iron therapy, received daily doses of 500 mg of intravenous iron sucrose until the hemoglobin level was corrected or until receiving the total dose of intravenous iron calculated for each patient.Results: The mean and median Hb (g/dL) 6.47±1.656 and 6.6 (2) at baseline, 9.61±1.629 and 9.6 (2) at 2 weeks of treatment, 11.85±1.277 and 12 (1) at 4 weeks of treatment respectively. The mean rise of Hb was 3.13±1.41 and 5.37±1.50 after 2 and 4 weeks of treatment respectively (p<0.000). A total of 303 intravenous infusions of iron sucrose were administered and iron sucrose was generally well tolerated with twenty-six patients developing mild and one patient developing moderate adverse drug reactions. There was no serious adverse event recorded.Conclusions: Accelerated high dose intravenous iron sucrose is a safe and cost effective option minimizing frequent hospital visits in the treatment of adults with iron deficiency anemia who are intolerant or lack satisfactory response to oral iron therapy