Fusion and Evaluation of 3D Data and Excavation Documents for Comparison of Original and Digital Copy in the Case of a Megalithic Tomb

This contribution shows the preliminary results of the multidisciplinary cooperation of archaeological, technical and heritage issues using the example of the megalithic tomb Kleinenkneten II. The tomb was excavated in the 1930s, but big parts of the documentation have unfortunately been destroyed. Furthermore, some ancient interpretations need to be objectively reviewed. More than 500 historical image data visually document the historical excavation situation. In addition, the current situation was recorded in 3D using modern methods. Geodetic products, such as orthophotos, can be derived from modern data and compared with old plans. Also, a point cloud was calculated from historical images, which can be compared with the current situation. The combination of modern and historical data enables new archaeological interpretations. From a museum perspective, strategies for the construction of authentic value of the 3D model is considered, as well as its communication to the public

З історії озброєння козацького війська першої половини 18 ст.

В низці реформ, які спіткали у 18 ст. військо гетьманського регіменту, та їхня невелика частина, котра стосувалася озброєння є чи не найменше відомою не тільки широкому загалу істориків, але й вузьким спеціалістам з періоду. Перші спроби прищеплення козакам “регулярства” ще з часів Петра І були спрямовані головним чином, на впровадження адміністративних і організаційних новацій, впорядкування фінансування й забезпечення при одночасному нехтуванні власне озброєнням і бойовою підготовкою війська. Втім, саме вони після Північної війни і “Низових” походів, які виявили всі недоліки, притаманні становій організації збройних сил, дуже гостро поставили питання боєздатності козацьких полків. Наріжною проблемою була якість озброєння реєстрових козаків. Як відомо, для цієї частини гетьманського війська традиційно не існувало жодних регламентацій, що б визначали види й перелік озброєння, термін його служби, навчання застосування тощо. Виняток становили лише наймані формування, забезпечення яких вогнепальною й деякими іншими видами зброї, а також боєприпасами, перебрала на себе держава [1]. На початку 18 ст. комплекс озброєння лівобережного козацтва загалом мало чим відрізнявся від попереднього століття, складаючись з традиційних піки, шаблі, різноманітних видів рушниць й іноді – пістолів і луків зі стрілами [2]. Кожен козак мусив власним коштом купувати необхідну йому амуніцію та зброю, вряди-годи дістаючи зі скарбу лише боєприпаси до неї. В умовах постійно прогресуючої майнової диференціації козацтва це призводило з одного боку до того, що частина збіднілого товариства взагалі не могла відбувати воєнну службу, а та, що була спроможною оплачувати спорядження, озброювалася відповідно не до воєнних потреб, а своїх матеріальних можливостей і бажання. Так, при підготовці кампанії 1707 р., Петро І наказував Мазепі виправити до діючої армії виборних козаків і компанійців, “которые б имели добрые кони и ружье”, дорікаючи за минулорічні бої в яких у козаків “почитай что ни у кого сабли не видали, кроме пищалей и сайдаков” [3]. Стан озброєності істотно погіршився ще й внаслідок поразок гетьманського війська у битвах зі шведами, виснажливих чергувань на форпостах і походів на Каспій. Годі й говорити, що за таких умов будь-яка уніфікація козацького озброєння була справою бажаною, але надзвичайно складною. Скарб Гетьманщини після численних реформ Малоросійської колегії й хронічної децентралізованості фінансового господарства навряд чи зміг би подужати проведення подібних заходів. Окрім того, в Україні практично не існувало ані необхідної сировинної бази, ані мережі зброярських підприємств мануфактурного типу, котрі б працювали на державне замовлення й могли б виконувати великі замовлення. Розвиток численних рудень Лівобережжя, котрі були зобовязані віддавати частину продукованого ними заліза на потребу війська, як відомо, не призвів до їх перетворення на металургійні заводи

Differentiated MSCs seeded in a highly dense collagenous matrix produce novel biphasic Osteochondral constructs

Structural damage to both the articular cartilage and subchondral bone results in pain and disability for millions of people worldwide, representing a major clinical challenge. Being a hybrid of both bone and cartilage, requirements for osteochondral tissue engineering are more complex than previously investigated single tissue types. Novel methods of integrating bone and cartilage tissue constructs need to be explored. In this study, two hyper-hydrated collagen gels, containing osteogenic and chondrogenic cells, were integrated to create a biphasic osteochondral construct

Quantitative analysis by renormalized entropy of invasive electroencephalograph recordings in focal epilepsy

Invasive electroencephalograph (EEG) recordings of ten patients suffering from focal epilepsy were analyzed using the method of renormalized entropy. Introduced as a complexity measure for the different regimes of a dynamical system, the feature was tested here for its spatio-temporal behavior in epileptic seizures. In all patients a decrease of renormalized entropy within the ictal phase of seizure was found. Furthermore, the strength of this decrease is monotonically related to the distance of the recording location to the focus. The results suggest that the method of renormalized entropy is a useful procedure for clinical applications like seizure detection and localization of epileptic foci.Comment: 10 pages, 5 figure

Depth versus surface: A critical review of subdural and depth electrodes in intracranial electroencephalographic studies

Intracranial electroencephalographic (IEEG) recording, using subdural electrodes (SDEs) and stereoelectroencephalography (SEEG), plays a pivotal role in localizing the epileptogenic zone (EZ). SDEs, employed for superficial cortical seizure foci localization, provide information on two-dimensional seizure onset and propagation. In contrast, SEEG, with its three-dimensional sampling, allows exploration of deep brain structures, sulcal folds, and bihemispheric networks. SEEG offers the advantages of fewer complications, better tolerability, and coverage of sulci. Although both modalities allow electrical stimulation, SDE mapping can tessellate cortical gyri, providing the opportunity for a tailored resection. With SEEG, both superficial gyri and deep sulci can be stimulated, and there is a lower risk of afterdischarges and stimulation-induced seizures. Most systematic reviews and meta-analyses have addressed the comparative effectiveness of SDEs and SEEG in localizing the EZ and achieving seizure freedom, although discrepancies persist in the literature. The combination of SDEs and SEEG could potentially overcome the limitations inherent to each technique individually, better delineating seizure foci. This review describes the strengths and limitations of SDE and SEEG recordings, highlighting their unique indications in seizure localization, as evidenced by recent publications. Addressing controversies in the perceived usefulness of the two techniques offers insights that can aid in selecting the most suitable IEEG in clinical practice

Acute Disseminated Encephalomyelitis with Seizures and Myocarditis: A Fatal Triad.

Autoimmune pathology of acute disseminated encephalomyelitis (ADEM) is generally restricted to the brain. Our objective is to expand the phenotype of ADEM. A four-year-old girl was admitted to the pediatric emergency room of a university medical center five days after a common upper respiratory tract infection. Acute symptoms were fever, leg pain, and headaches. She developed meningeal signs, and her level of consciousness dropped rapidly. Epileptic seizure activity started, and she became comatose, requiring intubation and mechanical ventilation. Serial brain magnetic resonance imaging (MRI) illustrated the fulminant development of ADEM. Treatment escalation with high-dose corticosteroids, immunoglobulins, and plasma exchange did not lead to clinical improvement. On day ten, the patient developed treatment-refractory cardiogenic shock and passed away. The postmortem assessment confirmed ADEM and revealed acute lymphocytic myocarditis, likely explaining the acute cardiac failure. Human metapneumovirus and picornavirus were detected in the tracheal secrete by PCR. Data sources-medical chart of the patient. This case is consistent with evidence from experimental findings of an association of ADEM with myocarditis as a postinfectious systemic autoimmune response, with life-threatening involvement of the brain and heart

High loading of polygenic risk for ADHD in children with comorbid aggression

Objective: Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk. There is evidence that aggression or conduct disorder in children with ADHD indexes higher genetic loading and clinical severity. The authors examine whether common genetic variants considered en masse as polygenic scores for ADHD are especially enriched in children with comorbid conduct disorder. Method: Polygenic scores derived from an ADHD GWAS meta-analysis were calculated in an independent ADHD sample (452 case subjects, 5,081 comparison subjects). Multivariate logistic regression analyses were employed to compare polygenic scores in the ADHD and comparison groups and test for higher scores in ADHD case subjects with comorbid conduct disorder relative to comparison subjects and relative to those without comorbid conduct disorder. Association with symptom scores was tested using linear regression. Results: Polygenic risk for ADD, derived from the meta-analysis, was higher in the independent ADHD group than in the comparison group. Polygenic score was significantly higher in ADHD case subjects with conduct disorder relative to ADHD case subjects without conduct disorder. ADHD polygenic score showed significant association with comorbid conduct disorder symptoms. This relationship was explained by,the aggression items. Conclusions: Common genetic variation is relevant to ADHD, especially in individuals with comorbid aggression. The findings suggest that the previously published ADHD GWAS meta-analysis contains weak but true associations with common variants, support for which falls below genome-wide significance levels. The findings also highlight the fact that aggression in ADHD indexes genetic as well as clinical severity

Impact of Vitamin C on Endothelial Function and Exercise Capacity in Patients with a Fontan Circulation

Objective.  To evaluate the impact of antioxidant therapy on functional health status in Fontan‐palliated patients. Design.  Prospective, randomized, double‐blind, placebo‐controlled trial. Patients.  Fifty‐three generally asymptomatic Fontan patients. Interventions.  Patients were randomized to receive either high‐dose ascorbic acid (vitamin C) or placebo for 4 weeks. Outcome Measures.  Peripheral vascular function, as measured with endothelium‐dependent digital pulse amplitude testing (EndoPAT), and exercise capacity were assessed before and after study drug treatment. Primary outcome measures included the EndoPAT index and peripheral arterial tonometry (PAT) ratio, both validated markers of vascular function. Secondary outcome measures included peak oxygen consumption and work. Results.  Twenty‐three vitamin C‐ and 21 placebo‐assigned subjects completed the protocol (83%). Median age and time from Fontan completion were 15 (interquartile range [IQR] 11.7–18.2) and 11.9 years (IQR 9.0–15.7), respectively. Right ventricular morphology was dominant in 30 (57%). Outcome measures were similar between groups at baseline. Among all subjects, vitamin C therapy was not associated with a statistical improvement in either primary or secondary outcome measures. In subjects with abnormal vascular function at baseline, compared with placebo, vitamin C therapy more frequently resulted in normalization of the EndoPAT index (45% vs. 17%) and PAT ratio (38% vs. 13%). Conclusions.  Short‐term therapy with vitamin C does not alter endothelial function or exercise capacity in an asymptomatic Fontan population overall. Vitamin C may provide benefit to a subset of Fontan patients with abnormal vascular function.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/92126/1/j.1747-0803.2011.00605.x.pd