Smoking, dementia and cognitive decline in the elderly, a systematic review.

Background. Nicotine may aid reaction time, learning and memory, but smoking increases cardiovascular risk. Cardiovascular risk factors have been linked to increased risk of dementia. A previous meta-analysis found that current smokers were at higher risk of subsequent dementia, Alzheimers disease, vascular dementia and cognitive decline. Methods. In order to update and examine this further a systematic review and meta-analysis was carried out using different search and inclusion criteria, database selection and more recent publications. Both reviews were restricted to those aged 65 and over. Results. The review reported here found a significantly increased risk of Alzheimers disease with current smoking and a likely but not significantly increased risk of vascular dementia, dementia unspecified and cognitive decline. Neither review found clear relationships with former smoking. Conclusion. Current smoking increases risk of Alzheimers disease and may increase risk of other dementias. This reinforces need for smoking cessation, particularly aged 65 and over. Nicotine alone needs further investigation. © 2008 Peters et al; licensee BioMed Central Ltd

Impact-induced acceleration by obstacles

We explore a surprising phenomenon in which an obstruction accelerates, rather than decelerates, a moving flexible object. It has been claimed that the right kind of discrete chain falling onto a table falls \emph{faster} than a free-falling body. We confirm and quantify this effect, reveal its complicated dependence on angle of incidence, and identify multiple operative mechanisms. Prior theories for direct impact onto flat surfaces, which involve a single constitutive parameter, match our data well if we account for a characteristic delay length that must impinge before the onset of excess acceleration. Our measurements provide a robust determination of this parameter. This supports the possibility of modeling such discrete structures as continuous bodies with a complicated constitutive law of impact that includes angle of incidence as an input.Comment: small changes and corrections, added reference

The structure of Gelfand-Levitan-Marchenko type equations for Delsarte transmutation operators of linear multi-dimensional differential operators and operator pencils. Part 1

An analog of Gelfand-Levitan-Marchenko integral equations for multi- dimensional Delsarte transmutation operators is constructed by means of studying their differential-geometric structure based on the classical Lagrange identity for a formally conjugated pair of differential operators. An extension of the method for the case of affine pencils of differential operators is suggested.Comment: 12 page

Friction force microscopy : a simple technique for identifying graphene on rough substrates and mapping the orientation of graphene grains on copper

At a single atom thick, it is challenging to distinguish graphene from its substrate using conventional techniques. In this paper we show that friction force microscopy (FFM) is a simple and quick technique for identifying graphene on a range of samples, from growth substrates to rough insulators. We show that FFM is particularly effective for characterizing graphene grown on copper where it can correlate the graphene growth to the three-dimensional surface topography. Atomic lattice stick–slip friction is readily resolved and enables the crystallographic orientation of the graphene to be mapped nondestructively, reproducibly and at high resolution. We expect FFM to be similarly effective for studying graphene growth on other metal/locally crystalline substrates, including SiC, and for studying growth of other two-dimensional materials such as molybdenum disulfide and hexagonal boron nitride

In vitro induction of tumour-specific immunity V. Detection of common antigenic determinatnts of murine fibrosarcomas.

Two 3-methylcholanthrene and a spontaneous BALB/c fibrosarcoma were examined for tumour-associated antigens (TAA) by in vivo and in vitro induction of tumour-immune responses. When BALB/c mice were immunized to these fibrosarcomas by surgical tumour removal, cross-reacting tumour-associated transplantation antigens (TATA) were detected on all 3 tumours. Cytotoxic effector cells (CL) were then induced in vitro by co-culture of BALB/c spleen cells with the spontaneous, or one of the carcinogen-induced fibrosarcomas. These CL were shown to be cytotoxic T cells (Tc) and to be directed against cross-reacting TAA on all 3 tumours, by two in vitro 51Cr-release assay systems, direct 51Cr-release cytotoxicity and cellular competitive inhibition of 51Cr release. Further studies demonstrated that the fibrosarcoma TAA involved in in vitro induction of Tc were not present on normal adult or foetal tissues. A secondary cytotoxic response was also detected in vitro when spleen cells from mice immunized to a carcinogen-induced fibrosarcoma were tested. The patterns of cross-reactivity detected by the in vivo and primary in vitro tumour-immune responses suggested that the TAA detected in vivo (TATA) were not identical to the TAA detected in vitro

A Technique for the Quantitative Study of Carotid Sinus Behavior

journal articleBiomedical Informatic

Electro-Mechanical Fredericks Effects in Nematic Gels

The solid nematic equivalent of the Fredericks transition is found to depend on a critical field rather than a critical voltage as in the classical case. This arises because director anchoring is principally to the solid rubbery matrix of the nematic gel rather than to the sample surfaces. Moreover, above the threshold field, we find a competition between quartic (soft) and conventional harmonic elasticity which dictates the director response. By including a small degree of initial director misorientation, the calculated field variation of optical anisotropy agrees well with the conoscopy measurements of Chang et al (Phys.Rev.E56, 595, 1997) of the electro-optical response of nematic gels.Comment: Latex (revtex style), 5 EPS figures, submitted to PRE, corrections to discussion of fig.3, cosmetic change

Double precision trajectory program /DPTRAJ 2.2C/

Four part program computes trajectory of space probe moving in solar system and subject to variety of forces

United States benefits of improved worldwide wheat crop information from a LANDSAT system

The value of worldwide information improvements on wheat crops, promised by LANDSAT, is measured in the context of world wheat markets. These benefits are based on current LANDSAT technical goals and assume that information is made available to all (United States and other countries) at the same time. A detailed empirical sample demonstration of the effect of improved information is given; the history of wheat commodity prices for 1971-72 is reconstructed and the price changes from improved vs. historical information are compared. The improved crop forecasting from a LANDSAT system assumed include wheat crop estimates of 90 percent accuracy for each major wheat producing region. Accurate, objective worldwide wheat crop information using space systems may have a very stabilizing influence on world commodity markets, in part making possible the establishment of long-term, stable trade relationships

Natural cytotoxicity of haemopoietic cell populations against murine lymphoid tumours.

Homozygous nude and normal mice of 3 strains, BALB/c, CBA and C57BL, were used as sources of nucleated haemopoietic "natural killer" (NK) cells. These killer cells could lyse a wide range of syngeneic and allogeneic lymphoid tumour cell lines in vitro, and it was found that cell suspensions from nude mice were always significantly more active than those from normal mice, and that the most active effector population was a polymorph-enriched peritoneal-exudate cell suspension. Eosinophils did not appear to be involved in the phenomenon, and mononuclear peritoneal-exudate cell suspensions were actually highly inhibitory. Three non-lymphoid tumours, a carcinoma, a fibrosarcoma and a mastocytoma, were totally resistant to in vitro lysis. Although all susceptible tumour cell lines were C-type virus-associated, not all of these tumours were killed by all strain sources of spleen cells, indicating a specificity of killing