High-Tip-Speed, Low-Loading Transonic Fan Stage. Part 1: Aerodynamic and Mechanical Design

A high-tip-speed, low-loading transonic fan stage was designed to deliver an overall pressure ratio of 1.5 with an adiabatic efficiency of 86 percent. The design flow per unit annulus area is 42.0 pounds per square foot. The fan features a hub/tip ratio of 0.46, a tip diameter of 28.74 in. and operates at a design tip speed of 1600 fps. For these design conditions, the rotor blade tip region operates with supersonic inlet and supersonic discharge relative velocities. A sophisticated quasi-three-dimensional characteristic section design procedure was used for the all-supersonic sections and the inlet of the midspan transonic sections. For regions where the relative outlet velocities are supersonic, the blade operates with weak oblique shocks only

Global monitoring of tropospheric water vapor with GPS radio occultation aboard CHAMP

The paper deals with application of GPS radio occultation (RO) measurements aboard CHAMP for the retrieval of tropospheric water vapor profiles. The GPS RO technique provides a powerful tool for atmospheric sounding which requires no calibration, is not affected by clouds, aerosols or precipitation, and provides an almost uniform global coverage. We briefly overview data processing and retrieval of vertical refractivity, temperature and water vapor profiles from GPS RO observations. CHAMP RO data are available since 2001 with up to 200 high resolution atmospheric profiles per day. Global validation of CHAMP water vapor profiles with radiosonde data reveals a bias of about 0.2 g/kg and a standard deviation of less than 1 g/kg specific humidity in the lower troposphere. We demonstrate potentials of CHAMP RO retrievals for monitoring the mean tropospheric water vapor distribution on a global scale.Comment: 7 pages, 4 figure

Study of several factors affecting crew escape trajectories from the Space Shuttle Orbiter at low-subsonic speeds

Factors affecting the bailout characteristics from the space shuttle orbiter at low-subsonic speeds were investigated. In the 12-foot low-speed tunnel and the 4 by 7-meter tunnel with 0.03-scale models. The effect of crew-model exit velocity, body position, and body weight were studied with egress from the main side hatch with the orbiter upright and from the upper cabin hatch with the orbiter inverted. Crew model drag and flow field measurements around the orbiter were estimated. The high-angle-of-attack trim characteristics of the orbiter was determined by force tests in an attempt to improve bailout conditions. A computer simulation was made to evaluate the maneuver necessary to attain the high-angle-of-attack trim

Cross-Cultural Understanding of Health Assessments for People with Intellectual Disability: An Australian resource in the Philippines

The Convention on the Rights of Persons with Disabilities has resulted in the involvement of high income countries in international development assistance to people with disabilities in low and middle income countries.  Healthcare tools designed in high income countries and delivered in low and middle income countries may not be appropriate to the context of the lives of people with disabilities.  We undertook a short qualitative study of participants’ views of an Australian-designed comprehensive health assessment tool, with participation from a WHO-Collaborating non-government organisation in regional Philippines. We also examined the participants’ perceptions of the barriers to healthcare for Filipinos with intellectual disabilities.  Responses to the comprehensive health assessment tool were positive although participants agreed that both linguistic and cultural translation would enhance wider use of the tool. The barriers identified included poverty, family isolation, stigma and communication issues as preventing appropriate healthcare delivery to Filipinos with intellectual disability. Consideration must be given to the complexities of transference of healthcare resources to a low and middle income country context, as well as the systemic and cultural barriers to appropriate healthcare provision to people with disabilities

A Coloring Algorithm for Disambiguating Graph and Map Drawings

Drawings of non-planar graphs always result in edge crossings. When there are many edges crossing at small angles, it is often difficult to follow these edges, because of the multiple visual paths resulted from the crossings that slow down eye movements. In this paper we propose an algorithm that disambiguates the edges with automatic selection of distinctive colors. Our proposed algorithm computes a near optimal color assignment of a dual collision graph, using a novel branch-and-bound procedure applied to a space decomposition of the color gamut. We give examples demonstrating the effectiveness of this approach in clarifying drawings of real world graphs and maps

Electrical Spin Pumping of Quantum Dots at Room Temperature

We report electrical control of the spin polarization of InAs/GaAs self-assembled quantum dots (QDs) at room temperature. This is achieved by electrical injection of spin-polarized electrons from an Fe Schottky contact. The circular polarization of the QD electroluminescence shows that a 5% electron spin polarization is obtained in the InAs QDs at 300 K, which is remarkably insensitive to temperature. This is attributed to suppression of the spin relaxation mechanisms in the QDs due to reduced dimensionality. These results demonstrate that practical regimes of spin-based operation are clearly attainable in solid state semiconductor devices.Comment: 4 figures, accepted by Appl. Phys. Let

Histiocytoid cardiomyopathy and microphthalmia with linear skin defects syndrome: phenotypes linked by truncating variants in NDUFB11

Variants in NDUFB11, which encodes a structural component of complex I of the mitochondrial respiratory chain (MRC), were recently independently reported to cause histiocytoid cardiomyopathy (histiocytoid CM) and microphthalmia with linear skin defects syndrome (MLS syndrome). Here we report an additional case of histiocytoid CM, which carries a de novo nonsense variant in NDUFB11 (ENST00000276062.8: c.262C > T; p.[Arg88*]) identified using whole-exome sequencing (WES) of a family trio. An identical variant has been previously reported in association with MLS syndrome. The case we describe here lacked the diagnostic features of MLS syndrome, but a detailed clinical comparison of the two cases revealed significant phenotypic overlap. Heterozygous variants in HCCS (which encodes an important mitochondrially targeted protein) and COX7B, which, like NDUFB11, encodes a protein of the MRC, have also previously been identified in MLS syndrome including a case with features of both MLS syndrome and histiocytoid CM. However, a systematic review of WES data from previously published histiocytoid CM cases, alongside four additional cases presented here for the first time, did not identify any variants in these genes. We conclude that NDUFB11 variants play a role in the pathogenesis of both histiocytoid CM and MLS and that these disorders are allelic (genetically related)

Cognitive representations of disability behaviours in people with mobility limitations : consistency with theoretical constructs

Disability is conceptualised as behaviour by psychological theory and as a result of bodily impairment by medical models. However, how people with disabilities conceptualise those disabilities is unclear. The purpose of this study was to examine disability representations in people with mobility disabilities. Thirteen people with mobility disabilities completed personal repertory grids (using the method of triads) applied to activities used to measure disabilities. Ten judges with expertise in health psychology then examined the correspondence between the elicited disability constructs and psychological and medical models of disability. Participants with mobility disabilities generated 73 personal constructs ofdisability. These constructs were judged consistent with the content of two psychological models, namely the theory of planned behaviour and social cognitive theory and with the main medical model of disability, the International Classification of Functioning Disability and Health.Individuals with activity limitations conceptualise activities in a manner that is compatible with both psychological and medical models. This ensures adequate communication in contexts where the medical model is relevant, e.g. clinical contexts, as well as in everyday conversation about activities and behaviours. Finally, integrated models of disability may be of value for theory driven interdisciplinary approaches to disability and rehabilitation

Stopping of Charged Particles in a Magnetized Classical Plasma

The analytical and numerical investigations of the energy loss rate of the test particle in a magnetized electron plasma are developed on the basis of the Vlasov-Poisson equations, and the main results are presented. The Larmor rotation of a test particle in a magnetic field is taken into account. The analysis is based on the assumption that the energy variation of the test particle is much less than its kinetic energy. The obtained general expression for stopping power is analyzed for three cases: (i) the particle moves through a collisionless plasma in a strong homogeneous magnetic field; (ii) the fast particle moves through a magnetized collisionless plasma along the magnetic field; and (iii) the particle moves through a magnetized collisional plasma across a magnetic field. Calculations are carried out for the arbitrary test particle velocities in the first case, and for fast particles in the second and third cases. It is shown that the rate at which a fast test particle loses energy while moving across a magnetic field may be much higher than the loss in the case of motion through plasma without magnetic field.Comment: 14 pages, 3 figures, LaTe

Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub-Saharan Africa.

Despite its well-described safety and efficacy in the treatment of sickle cell anemia (SCA) in high-income settings, hydroxyurea remains largely unavailable in sub-Saharan Africa, where more than 75% of annual SCA births occur and many comorbidities exist. Realizing Effectiveness Across Continents with Hydroxyurea (REACH, ClinicalTrials.gov NCT01966731) is a prospective, Phase I/II open-label trial of hydroxyurea designed to evaluate the feasibility, safety, and benefits of hydroxyurea treatment for children with SCA in four sub-Saharan African countries. Following comprehensive training of local research teams, REACH was approved by local Ethics Committees and achieved full enrollment ahead of projections with 635 participants enrolled over a 30-month period, despite half of families living \u3e12 km from their clinical site. At enrollment, study participants (age 5.4 ± 2.4 years) had substantial morbidity, including a history of vaso-occlusive pain (98%), transfusion (68%), malaria (85%), and stroke (6%). Significant differences in laboratory characteristics were noted across sites, with lower hemoglobin concentrations (P \u3c .01) in Angola (7.2 ± 1.0 g/dL) and the DRC (7.0 ± 0.9 g/dL) compared to Kenya (7.4 ± 1.1 g/dL) and Uganda (7.5 ± 1.1 g/dL). Analysis of known genetic modifiers of SCA demonstrated a high frequency of α-thalassemia (58.4% with at least a single α-globin gene deletion) and G6PD deficiency (19.7% of males and 2.4% of females) across sites. The CAR β-globin haplotype was present in 99% of participants. The full enrollment to REACH confirms the feasibility of conducting high-quality SCA research in Africa; this study will provide vital information to guide safe and effective dosing of hydroxyurea for children with SCA living in Africa