Viscoelastic deformation near active plate boundaries

Model deformations near the active plate boundaries of Western North America using space-based geodetic measurements as constraints are discussed. The first six months of this project were spent gaining familarity with space-based measurements, accessing the Crustal Dynamics Data Information Computer, and building time independent deformation models. The initial goal was to see how well the simplest elastic models can reproduce very long base interferometry (VLBI) baseline data. From the Crustal Dynamics Data Information Service, a total of 18 VLBI baselines are available which have been surveyed on four or more occasions. These data were fed into weighted and unweighted inversions to obtain baseline closure rates. Four of the better quality lines are illustrated. The deformation model assumes that the observed baseline rates result from a combination of rigid plate tectonic motions plus a component resulting from elastic strain build up due to a failure of the plate boundary to slip at the full plate tectonic rate. The elastic deformation resulting from the locked plate boundary is meant to portray interseismic strain accumulation. During and shortly after a large interplate earthquake, these strains are largely released, and points near the fault which were previously retarded suddenly catch up to the positions predicted by rigid plate models. Researchers judge the quality of fit by the sum squares of weighted residuals, termed total variance. The observed baseline closures have a total variance of 99 (cm/y)squared. When the RM2 velocities are assumed to model the data, the total variance increases to 154 (cm/y)squared

Children’s travel as pedestrians: an international survey of policy and practice

A survey of OECD member countries was carried out to provide high level data on a consistent basis to identify and account for current patterns of child road safety . This paper reports the findings relating to children, aged 0-14 years, as pedestrians. Key survey elements included analyses of fatality data, relationships between socio-economic, demographic factors and fatality rates, and a questionnaire based survey. League tables based on average child pedestrian fatality rates were constructed for each OECD member country participating in our questionnaire enabling identification of the top five countries with the lowest pedestrian fatality rate as Sweden, The Netherlands, Finland, Germany, and Denmark. Few countries had quantitative information about children’s travel and its absence means that assessments are difficult about children’s safety and the relative risks they face, especially as pedestrians. There are large variations in the amount of walking between countries and growing car use is becoming an issue in one third of OECD countries. The main findings from the questionnaire survey were that the majority of countries did not have information on high risk groups but of those that did, the cross cutting themes of socio-economic and ethnic minority groups, young children and urban areas were identified. Three characteristics distinguish top countries in the League table from those doing less well: a strong approach to the introduction of infrastructure measures for pedestrian safety, including low speed limits in residential areas; conducting road safety campaigns at least once a year; and having legislation which assumes driver responsibility in an accident involving a child pedestrian. Having compulsory road safety education for children aged 6-9 years was a characteristic shared by most countries, as was the promotion of child pedestrian education and training initiatives and the commissioning of research. However there is lower research activity in less well performing countries

Night-time accidents: a scoping study. Report to The AA Motoring Trust and Rees Jeffreys Road Fund

Context: Only a quarter of all travel by car drivers is undertaken between the hours of 19.00 and 08.00, but it is in this period that 40 percent of fatal and serious injuries are sustained by drivers. This indicates that car travel at night carries a greater risk of being killed or seriously injured than does travel during the day. The literature indicates that disproportionate numbers of young drivers, especially young men, are injured at night. But to be able to introduce measures targeted at this group more needs to be known about the purpose of their journeys, the types of roads they travel on, and how far they drive and at what times in the evening and at night. Older drivers tend to have fewer accidents at night, but little is currently known about how much can be accounted for by exposure related to their driving patterns. People over the age of 60 years form about 20 percent of the population, yet they make up over a quarter of traffic fatalities. These two groups of young and older drivers have been selected for study with the following aims: (a) to assess what information exists which relates to night-time exposure by activity and by group (young and older); (b) to assess what is known about exposure and risk to young and older drivers at night, in conjunction with an analysis of relevant accident data to provide a picture of the size of the potential problem areas, and gaps in current knowledge; (c) to identify people’s concerns, attitudes and beliefs with regard to the problems of night-time driving; and (d) to provide the basis for decision on what measures might be brought to bear on the problem, and what further research would be needed in order to point to focused action. This scoping study is in two parts and provides an assessment of the information available and hence the gaps in our knowledge on the nature and extent of night-time driving, and the risks involved at these times. The first part assesses the available data, and the second uses focus groups to gather the views of drivers themselves, together with their concerns, attitudes and beliefs with regard to the problems of night-time driving. The measurement of exposure, or amount of travel by car, of drivers of different age and gender is central to the assessment of the risk of being killed or injured in a road traffic accident. In this study, the measure of exposure used is distance travelled per person per year. This has been combined with casualty data to make preliminary assessments of risk to people of different ages and gender of driving at during the daytime and at night

Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer: systematic review and economic evaluation

Objectives: To evaluate the clinical and costeffectiveness of capecitabine and tegafur with uracil (UFT/LV) as first-line treatments for patients with metastatic colorectal cancer, as compared with 5- fluorouracil/folinic acid (5-FU/FA) regimens. Data sources: Electronic databases, reference lists of relevant articles and sponsor submissions were also consulted. Review methods: Systematic searches, selection against criteria and quality assessment were performed to obtain data from relevant studies. Costs were estimated through resource-use data taken from the published trials and the unpublished sponsor submissions. Unit costs were taken from published sources, where available. An economic evaluation was undertaken to compare the cost-effectiveness of capecitabine and UFT/LV with three intravenous 5- FU/LV regimens widely used in the UK: the Mayo, the modified de Gramont regimen and the inpatient de Gramont regimens. Results: The evidence suggests that treatment with capecitabine improves overall response rates and has an improved adverse effect profile in comparison with 5-FU/LV treatment with the Mayo regimen, with the exception of hand–foot syndrome. Time to disease progression or death after treatment with UFT/LV in one study appears to be shorter than after treatment with 5-FU/LV with the Mayo regimen, although it also had an improved adverse effect profile. Neither capecitabine nor UFT/LV appeared to improve healthrelated quality of life. Little information on patient preference was available for UFT/LV, but there was indicated a strong preference for this over 5-FU/LV. The total cost of capecitabine and UFT/LV treatments were estimated at £2111 and £3375, respectively, compared with the total treatment cost for the Mayo regimen of £3579. Cost estimates were also presented for the modified de Gramont and inpatient de Gramont regimens. These were £3684 and £6155, respectively. No survival advantage was shown in the RCTs of the oral drugs against the Mayo regimen. Cost savings of capecitabine and UFT/LV over the Mayo regimen were estimated to be £1461 and £209, respectively. Drug acquisition costs were higher for the oral therapies than for the Mayo regimen, but were offset by lower administration costs. Adverse event treatment costs were similar across the three regimens. It was inferred that there was no survival difference between the oral drugs and the de Gramont regimens. Cost savings of capecitabine and UFT/LV over the modified de Gramont regimen were estimated to be £1353 and £101, respectively, and over the inpatient de Gramont regimen were estimated to be £4123 and £2870, respectively. Conclusions: The results show that there are cost savings associated with the use of oral therapies. No survival difference has been proven between the oral drugs and the Mayo regimen. In addition, no evidence of a survival difference between the Mayo regimen and the de Gramont regimens has been identified. However, improved progression-free survival and an improved adverse event profile have been shown for the de Gramont regimen over the Mayo regimen. Further research is recommended into the following areas: quality of life data should be included in trials of colorectal cancer treatments; the place of effective oral treatments in the treatment of colorectal cancer, the safety mechanisms needed to ensure compliance and the monitoring of adverse effects; the optimum duration of treatment; the measurement of patient preference; and a phase III comparative trial of capecitabine and UFT/LV versus modified de Gramont treatment to determine whether there was any survival advantage and to collate the necessary economic data

Fatal injuries to car occupants: analysis of health and population data

Although this report was commissioned by the Department for Transport (DfT), the findings and recommendations are those of the authors and do not necessarily represent the views of the DfT. While the DfT has made every effort to ensure the information in this document is accurate, DfT does not guarantee the accuracy, completeness or usefulness of that information; and it cannot accept liability for any loss or damages of any kind resulting from reliance on the information or guidance this document contains

Bond patterns and charge order amplitude in 1/4-filled charge-transfer solids

Metal-insulator transition accompanied by charge-ordering has been widely investigated in quasi-one-dimensional conductors, including in particular organic charge-transfer solids. Among such materials the 1/4-filled band charge-transfer solids are of strong interest, because of the commensurate nature of the charge-ordering in these systems. The period-four charge-order pattern ...1100... here is accompanied by two distinct bond distortion patterns, giving rise to bond-charge-density waves (BCDW) of types 1 and 2. Using quantum Monte Carlo methods, we determine the phase diagram within the extended Hubbard Hamiltonian that gives both types 1 and 2 BCDW in the thermodynamic limit. We further investigate the effect of electron-electron and electron-phonon interactions on the amount of charge disproportionation. Our results show that between these two bond patterns, one (BCDW2) in general coexists with a large magnitude charge order, which is highly sensitive to electron-phonon interactions, while the other (BCDW1) is characterized by weak charge order. We discuss the relevance of our work to experiments on several 1/4-filled conductors, focusing in particular on the materials (EDO-TTF)_2X and (DMEDO-TTF)_2X with large amplitude charge-order.Comment: 7 pages, 8 figure

From 2D Integrable Systems to Self-Dual Gravity

We explain how to construct solutions to the self-dual Einstein vacuum equations from solutions of various two-dimensional integrable systems by exploiting the fact that the Lax formulations of both systems can be embedded in that of the self-dual Yang--Mills equations. We illustrate this by constructing explicit self-dual vacuum metrics on $\R^2\times \Sigma$, where $\Sigma$ is a homogeneous space for a real subgroup of SL(2, \C) associated with the two-dimensional system.Comment: 9 pages, LaTex, no figure

Kink dynamics in a novel discrete sine-Gordon system

A spatially-discrete sine-Gordon system with some novel features is described. There is a topological or Bogomol'nyi lower bound on the energy of a kink, and an explicit static kink which saturates this bound. There is no Peierls potential barrier, and consequently the motion of a kink is simpler, especially at low speeds. At higher speeds, it radiates and slows down.Comment: 10 pages, 7 figures, archivin

Psychological Issues in Online Adaptive Task Allocation

Adaptive aiding is an idea that offers potential for improvement over many current approaches to aiding in human-computer systems. The expected return of tailoring the system to fit the user could be in the form of improved system performance and/or increased user satisfaction. Issues such as the manner in which information is shared between human and computer, the appropriate division of labor between them, and the level of autonomy of the aid are explored. A simulated visual search task was developed. Subjects are required to identify targets in a moving display while performing a compensatory sub-critical tracking task. By manipulating characteristics of the situation such as imposed task-related workload and effort required to communicate with the computer, it is possible to create conditions in which interaction with the computer would be more or less desirable. The results of preliminary research using this experimental scenario are presented, and future directions for this research effort are discussed